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Q9D2N4

- DTNA_MOUSE

UniProt

Q9D2N4 - DTNA_MOUSE

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Protein

Dystrobrevin alpha

Gene
Dtna, Dtn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in synapse maturation and required for normal muscle function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typeAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: UniProtKB
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin alpha
Short name:
DTN-A
Alternative name(s):
Alpha-dystrobrevin
Gene namesi
Name:Dtna
Synonyms:Dtn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:106039. Dtna.

Subcellular locationi

Cytoplasm. Cell junctionsynapse. Cell membrane
Note: In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-SubCell
  3. dystrobrevin complex Source: UniProtKB
  4. protein complex Source: MGI
  5. sarcolemma Source: MGI
  6. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Dystrobrevin alphaPRO_0000080037Add
BLAST

Post-translational modificationi

Phosphorylation of isoform 2 on tyrosine kinase substrate domain present in the C-terminus.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D2N4.
PaxDbiQ9D2N4.
PRIDEiQ9D2N4.

PTM databases

PhosphoSiteiQ9D2N4.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, lung and brain. Sarcolemma and neuromuscular junction in skeletal muscle. Isoform 2 is restricted to the neuromuscular junction. Isoforms 5 and 6 are only expressed in muscle.

Developmental stagei

Expression of alpha-dystrobrevin is up-regulated during differentiation, with isoforms 2, 5 and 6 expressed earliest and isoform 3 and 4 expressed later.

Gene expression databases

ArrayExpressiQ9D2N4.
BgeeiQ9D2N4.
CleanExiMM_DTNA.
GenevestigatoriQ9D2N4.

Interactioni

Subunit structurei

Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoforms 5 and 6 do not interact with syntrophin. Isoforms 3 and 4 do not interact with utrophin. Binds dystrobrevin binding protein 1. Interacts with MAGEE1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dtnbp1Q91WZ83EBI-296019,EBI-643186

Protein-protein interaction databases

IntActiQ9D2N4. 6 interactions.
MINTiMINT-197169.

Structurei

3D structure databases

ProteinModelPortaliQ9D2N4.
SMRiQ9D2N4. Positions 26-235, 237-292.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 288288Interaction with MAGEE1Add
BLAST
Regioni397 – 44751Syntrophin-binding regionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili458 – 557100 Reviewed predictionAdd
BLAST

Domaini

The coiled coil domain mediates the interaction with dystrophin and utrophin.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG251970.
GeneTreeiENSGT00740000115370.
HOVERGENiHBG005539.
InParanoidiQ9D2N4.
PhylomeDBiQ9D2N4.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9D2N4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL    50
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 100
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 150
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 200
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 250
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 300
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS 350
VPSSGSPFIT RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA 400
DEHVLIGLYV NMLRNDPPCM LESSNRLDEE HRLIARYAAR LAAESSSSQP 450
TQQRSAPDIS FTIDANKQQR QLIAELENKN REILQEIQRL RVEHEQASQP 500
TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEGLMKLL 550
KEEELKQGTQ GASSPRSSPS HTISRPIPMP IRSASACPTP THTPQDSLTG 600
VGGDVQEAFA QSSRRNLRSD LLVAADSITN TMSSLVKELN SEVASETEST 650
VDSEFSRPQF EDLAPSPTSE KAFLAQIHSR KPGYIHGGAA STTHGDMVPE 700
DGDPYTQPED GNYENESVRQ LENELQLEEY LKQKLQDEAY QVSLQG 746
Length:746
Mass (Da):84,067
Last modified:February 8, 2011 - v2
Checksum:i6AB7EF3B69250A09
GO
Isoform 2 (identifier: Q9D2N4-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha-dystrobrevin-1, Alpha-DB1

The sequence of this isoform differs from the canonical sequence as follows:
     363-419: Missing.
     560-561: QG → R

Show »
Length:688
Mass (Da):77,733
Checksum:i82AC1104D48313EA
GO
Isoform 3 (identifier: Q9D2N4-3) [UniParc]FASTAAdd to Basket

Also known as: Alpha-dystrobrevin-2B, Alpha-DB2B

The sequence of this isoform differs from the canonical sequence as follows:
     559-570: TQGASSPRSSPS → VMHEIIPLEERT
     571-746: Missing.

Show »
Length:570
Mass (Da):65,157
Checksum:iCA135BFB7B7A3DDE
GO
Isoform 4 (identifier: Q9D2N4-4) [UniParc]FASTAAdd to Basket

Also known as: Alpha-dystrobrevin-2A, Alpha-DB2A

The sequence of this isoform differs from the canonical sequence as follows:
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Show »
Length:567
Mass (Da):64,763
Checksum:i73C843F6C9E27940
GO
Isoform 5 (identifier: Q9D2N4-5) [UniParc]FASTAAdd to Basket

Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Show »
Length:374
Mass (Da):42,380
Checksum:i286DE068A207D235
GO
Isoform 6 (identifier: Q9D2N4-6) [UniParc]FASTAAdd to Basket

Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Show »
Length:371
Mass (Da):41,977
Checksum:i444BB5947F3D5DD3
GO
Isoform 7 (identifier: Q9D2N4-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     363-419: Missing.
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Show »
Length:513
Mass (Da):58,860
Checksum:iEA3913DA5334D7E1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei334 – 3341V → VDTW in isoform 5 and isoform 7. VSP_004214
Alternative sequencei363 – 41957Missing in isoform 2 and isoform 7. VSP_004215Add
BLAST
Alternative sequencei364 – 3718PPKDSEVE → DGAHGGCV in isoform 5 and isoform 6. VSP_004216
Alternative sequencei372 – 746375Missing in isoform 5 and isoform 6. VSP_004217Add
BLAST
Alternative sequencei559 – 57012TQGAS…RSSPS → VMHEIIPLEERT in isoform 3. VSP_004221Add
BLAST
Alternative sequencei559 – 5679TQGASSPRS → VSYVPYCRS in isoform 4 and isoform 7. VSP_004218
Alternative sequencei560 – 5612QG → R in isoform 2. VSP_004220
Alternative sequencei568 – 746179Missing in isoform 4 and isoform 7. VSP_004219Add
BLAST
Alternative sequencei571 – 746176Missing in isoform 3. VSP_004222Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411V → L in CAA64519. 1 Publication
Sequence conflicti251 – 2511M → I in BAB31746. 1 Publication
Sequence conflicti259 – 2591Q → P in AAD33915. 1 Publication
Sequence conflicti416 – 4161D → N in AAD33915. 1 Publication
Sequence conflicti416 – 4161D → N in AAD33914. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95226 mRNA. Translation: CAA64518.1.
X95227 mRNA. Translation: CAA64519.1.
Z79787
, Z79788, Z79789, Z79790, Z79791, Z79792, Z79793, Z79794, Z79795, Z79796, Z79797 Genomic DNA. Translation: CAB02145.1.
AJ009669 mRNA. Translation: CAA08770.1.
AF143544 mRNA. Translation: AAD33915.1.
AF143543 mRNA. Translation: AAD33914.1.
AF143542 mRNA. Translation: AAD33913.1.
AK019477 mRNA. Translation: BAB31746.1.
CCDSiCCDS29094.1. [Q9D2N4-6]
RefSeqiNP_001272736.1. NM_001285807.1.
NP_001272739.1. NM_001285810.1.
NP_001272746.1. NM_001285817.1.
NP_034217.2. NM_010087.4. [Q9D2N4-6]
XP_006525682.1. XM_006525619.1.
XP_006525685.1. XM_006525622.1. [Q9D2N4-7]
UniGeneiMm.484047.
Mm.94371.

Genome annotation databases

EnsembliENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302. [Q9D2N4-6]
GeneIDi13527.
KEGGimmu:13527.
UCSCiuc008efs.1. mouse. [Q9D2N4-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95226 mRNA. Translation: CAA64518.1 .
X95227 mRNA. Translation: CAA64519.1 .
Z79787
, Z79788 , Z79789 , Z79790 , Z79791 , Z79792 , Z79793 , Z79794 , Z79795 , Z79796 , Z79797 Genomic DNA. Translation: CAB02145.1 .
AJ009669 mRNA. Translation: CAA08770.1 .
AF143544 mRNA. Translation: AAD33915.1 .
AF143543 mRNA. Translation: AAD33914.1 .
AF143542 mRNA. Translation: AAD33913.1 .
AK019477 mRNA. Translation: BAB31746.1 .
CCDSi CCDS29094.1. [Q9D2N4-6 ]
RefSeqi NP_001272736.1. NM_001285807.1.
NP_001272739.1. NM_001285810.1.
NP_001272746.1. NM_001285817.1.
NP_034217.2. NM_010087.4. [Q9D2N4-6 ]
XP_006525682.1. XM_006525619.1.
XP_006525685.1. XM_006525622.1. [Q9D2N4-7 ]
UniGenei Mm.484047.
Mm.94371.

3D structure databases

ProteinModelPortali Q9D2N4.
SMRi Q9D2N4. Positions 26-235, 237-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D2N4. 6 interactions.
MINTi MINT-197169.

PTM databases

PhosphoSitei Q9D2N4.

Proteomic databases

MaxQBi Q9D2N4.
PaxDbi Q9D2N4.
PRIDEi Q9D2N4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047954 ; ENSMUSP00000037475 ; ENSMUSG00000024302 . [Q9D2N4-6 ]
GeneIDi 13527.
KEGGi mmu:13527.
UCSCi uc008efs.1. mouse. [Q9D2N4-7 ]

Organism-specific databases

CTDi 1837.
MGIi MGI:106039. Dtna.

Phylogenomic databases

eggNOGi NOG251970.
GeneTreei ENSGT00740000115370.
HOVERGENi HBG005539.
InParanoidi Q9D2N4.
PhylomeDBi Q9D2N4.

Miscellaneous databases

NextBioi 284112.
PROi Q9D2N4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9D2N4.
Bgeei Q9D2N4.
CleanExi MM_DTNA.
Genevestigatori Q9D2N4.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF038204. Distrobrevin. 1 hit.
SMARTi SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
PROSITEi PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein."
    Blake D.J., Nawrotzki R., Peters M.F., Froehner S.C., Davies K.E.
    J. Biol. Chem. 271:7802-7810(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 7).
    Tissue: Brain.
  2. "Genomic organization of the mouse dystrobrevin gene: comparative analysis with the dystrophin gene."
    Ambrose H.J., Blake D.J., Nawrotzki R.A., Davies K.E.
    Genomics 39:359-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: 129/Sv.
    Tissue: Brain.
  3. "Characterisation of alpha-dystrobrevin in muscle."
    Nawrotzki R., Loh N.Y., Ruegg M.A., Davies K.E., Blake D.J.
    J. Cell Sci. 111:2595-2605(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Muscle.
  4. "Differential expression and developmental regulation of a novel alpha-dystrobrevin isoform in muscle."
    Enigk R.E., Maimone M.M.
    Gene 238:479-488(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 6).
    Strain: C3H.
    Tissue: Muscle.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Skin.
  6. "Interactions between dystrophin glycoprotein complex proteins."
    Madhavan R., Jarrett H.W.
    Biochemistry 34:12204-12209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNTA1.
  7. "Differential association of syntrophin pairs with the dystrophin complex."
    Peters M.F., Adams M.E., Froehner S.C.
    J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNTB1.
  8. "Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain."
    Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R., Blake D.J.
    J. Biol. Chem. 276:24232-24241(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYSTROBREVIN BINDING PROTEIN 1.
  9. "DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes."
    Albrecht D.E., Froehner S.C.
    J. Biol. Chem. 279:7014-7023(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MAGEE1.

Entry informationi

Entry nameiDTNA_MOUSE
AccessioniPrimary (citable) accession number: Q9D2N4
Secondary accession number(s): P97319
, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi