Q9D2N4 (DTNA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dystrobrevin alpha
Short name=DTN-A

Alternative name(s):
Alpha-dystrobrevin

Gene names

Name:	Dtna
Synonyms:	Dtn

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	746 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in synapse maturation and required for normal muscle function.
Subunit structure	Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoforms 5 and 6 do not interact with syntrophin. Isoforms 3 and 4 do not interact with utrophin. Binds dystrobrevin binding protein 1. Interacts with MAGEE1. Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Cytoplasm. Cell junction › synapse. Cell membrane. Note: In peripheral nerves, co-localizes with MAGEE1 in the Schwann cell membrane. Ref.9
Tissue specificity	Expressed in skeletal muscle, heart, lung and brain. Sarcolemma and neuromuscular junction in skeletal muscle. Isoform 2 is restricted to the neuromuscular junction. Isoforms 5 and 6 are only expressed in muscle.
Developmental stage	Expression of alpha-dystrobrevin is up-regulated during differentiation, with isoforms 2, 5 and 6 expressed earliest and isoform 3 and 4 expressed later.
Domain	The coiled coil domain mediates the interaction with dystrophin and utrophin.
Post-translational modification	Phosphorylation of isoform 2 on tyrosine kinase substrate domain present in the C-terminus.
Sequence similarities	Belongs to the dystrophin family. Dystrobrevin subfamily. Contains 1 ZZ-type zinc finger.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasm Membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell dystrobrevin complex Non-traceable author statement Ref.9. Source: UniProtKB sarcolemma Traceable author statement PubMed 14688250. Source: MGI synapse Inferred from direct assay PubMed 10995443. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dtnbp1	Q91WZ8	3	EBI-296019,EBI-643186

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9D2N4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9D2N4-2)

Also known as: Alpha-dystrobrevin-1; Alpha-DB1;

The sequence of this isoform differs from the canonical sequence as follows:
     363-419: Missing.
     560-561: QG → R

Isoform 3 (identifier: Q9D2N4-3)

Also known as: Alpha-dystrobrevin-2B; Alpha-DB2B;

The sequence of this isoform differs from the canonical sequence as follows:
     559-570: TQGASSPRSSPS → VMHEIIPLEERT
     571-746: Missing.

Isoform 4 (identifier: Q9D2N4-4)

Also known as: Alpha-dystrobrevin-2A; Alpha-DB2A;

The sequence of this isoform differs from the canonical sequence as follows:
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Isoform 5 (identifier: Q9D2N4-5)

Also known as: Alpha-dystrobrevin-3; Alpha-DB3;

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Isoform 6 (identifier: Q9D2N4-6)

Also known as: Alpha-dystrobrevin-3; Alpha-DB3;

The sequence of this isoform differs from the canonical sequence as follows:
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Isoform 7 (identifier: Q9D2N4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     363-419: Missing.
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 746	746	Dystrobrevin alpha		PRO_0000080037
Regions
	Zinc finger	237 – 284	48	ZZ-type
	Region	1 – 288	288	Interaction with MAGEE1
	Region	397 – 447	51	Syntrophin-binding region
	Coiled coil	458 – 557	100	Potential
Natural variations
	Alternative sequence	334	1	V → VDTW in isoform 5 and isoform 7.		VSP_004214
	Alternative sequence	363 – 419	57	Missing in isoform 2 and isoform 7.		VSP_004215
	Alternative sequence	364 – 371	8	PPKDSEVE → DGAHGGCV in isoform 5 and isoform 6.		VSP_004216
	Alternative sequence	372 – 746	375	Missing in isoform 5 and isoform 6.		VSP_004217
	Alternative sequence	559 – 570	12	TQGAS…RSSPS → VMHEIIPLEERT in isoform 3.		VSP_004221
	Alternative sequence	559 – 567	9	TQGASSPRS → VSYVPYCRS in isoform 4 and isoform 7.		VSP_004218
	Alternative sequence	560 – 561	2	QG → R in isoform 2.		VSP_004220
	Alternative sequence	568 – 746	179	Missing in isoform 4 and isoform 7.		VSP_004219
	Alternative sequence	571 – 746	176	Missing in isoform 3.		VSP_004222
Experimental info
	Sequence conflict	241	1	V → L in CAA64519. Ref.1
	Sequence conflict	251	1	M → I in BAB31746. Ref.5
	Sequence conflict	259	1	Q → P in AAD33915. Ref.4
	Sequence conflict	416	1	D → N in AAD33915. Ref.4
	Sequence conflict	416	1	D → N in AAD33914. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 8, 2011. Version 2. Checksum: 6AB7EF3B69250A09	FASTA	746	84,067
	10 20 30 40 50 60 MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 70 80 90 100 110 120 ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 130 140 150 160 170 180 PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 250 260 270 280 290 300 VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 310 320 330 340 350 360 NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT 370 380 390 400 410 420 RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA DEHVLIGLYV NMLRNDPPCM 430 440 450 460 470 480 LESSNRLDEE HRLIARYAAR LAAESSSSQP TQQRSAPDIS FTIDANKQQR QLIAELENKN 490 500 510 520 530 540 REILQEIQRL RVEHEQASQP TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM 550 560 570 580 590 600 VQLEGLMKLL KEEELKQGTQ GASSPRSSPS HTISRPIPMP IRSASACPTP THTPQDSLTG 610 620 630 640 650 660 VGGDVQEAFA QSSRRNLRSD LLVAADSITN TMSSLVKELN SEVASETEST VDSEFSRPQF 670 680 690 700 710 720 EDLAPSPTSE KAFLAQIHSR KPGYIHGGAA STTHGDMVPE DGDPYTQPED GNYENESVRQ 730 740 LENELQLEEY LKQKLQDEAY QVSLQG
	Isoform 2 (Alpha-dystrobrevin-1) (Alpha-DB1) [UniParc]. Checksum: 82AC1104D48313EA	FASTA	688	77,733
	10 20 30 40 50 60 MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 70 80 90 100 110 120 ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 130 140 150 160 170 180 PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 250 260 270 280 290 300 VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 310 320 330 340 350 360 NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT 370 380 390 400 410 420 RSMLESSNRL DEEHRLIARY AARLAAESSS SQPTQQRSAP DISFTIDANK QQRQLIAELE 430 440 450 460 470 480 NKNREILQEI QRLRVEHEQA SQPTPEKAQQ NPTLLAELRL LRQRKDELEQ RMSALQESRR 490 500 510 520 530 540 ELMVQLEGLM KLLKEEELKQ GTRASSPRSS PSHTISRPIP MPIRSASACP TPTHTPQDSL 550 560 570 580 590 600 TGVGGDVQEA FAQSSRRNLR SDLLVAADSI TNTMSSLVKE LNSEVASETE STVDSEFSRP 610 620 630 640 650 660 QFEDLAPSPT SEKAFLAQIH SRKPGYIHGG AASTTHGDMV PEDGDPYTQP EDGNYENESV 670 680 RQLENELQLE EYLKQKLQDE AYQVSLQG
	Isoform 3 (Alpha-dystrobrevin-2B) (Alpha-DB2B) [UniParc]. Checksum: CA135BFB7B7A3DDE	FASTA	570	65,157
	10 20 30 40 50 60 MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 70 80 90 100 110 120 ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 130 140 150 160 170 180 PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 250 260 270 280 290 300 VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 310 320 330 340 350 360 NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT 370 380 390 400 410 420 RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA DEHVLIGLYV NMLRNDPPCM 430 440 450 460 470 480 LESSNRLDEE HRLIARYAAR LAAESSSSQP TQQRSAPDIS FTIDANKQQR QLIAELENKN 490 500 510 520 530 540 REILQEIQRL RVEHEQASQP TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM 550 560 570 VQLEGLMKLL KEEELKQGVM HEIIPLEERT
	Isoform 4 (Alpha-dystrobrevin-2A) (Alpha-DB2A) [UniParc]. Checksum: 73C843F6C9E27940	FASTA	567	64,763
	10 20 30 40 50 60 MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 70 80 90 100 110 120 ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 130 140 150 160 170 180 PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 250 260 270 280 290 300 VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 310 320 330 340 350 360 NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT 370 380 390 400 410 420 RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA DEHVLIGLYV NMLRNDPPCM 430 440 450 460 470 480 LESSNRLDEE HRLIARYAAR LAAESSSSQP TQQRSAPDIS FTIDANKQQR QLIAELENKN 490 500 510 520 530 540 REILQEIQRL RVEHEQASQP TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM 550 560 VQLEGLMKLL KEEELKQGVS YVPYCRS
	Isoform 5 (Alpha-dystrobrevin-3) (Alpha-DB3) [UniParc]. Checksum: 286DE068A207D235	FASTA	374	42,380
	10 20 30 40 50 60 MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 70 80 90 100 110 120 ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 130 140 150 160 170 180 PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 250 260 270 280 290 300 VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 310 320 330 340 350 360 NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDTLF SHSVPSSGSP 370 FITRSSDGAH GGCV
	Isoform 6 (Alpha-dystrobrevin-3) (Alpha-DB3) [UniParc]. Checksum: 444BB5947F3D5DD3	FASTA	371	41,977
	10 20 30 40 50 60 MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 70 80 90 100 110 120 ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 130 140 150 160 170 180 PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 250 260 270 280 290 300 VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 310 320 330 340 350 360 NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT 370 RSSDGAHGGC V
	Isoform 7 [UniParc]. Checksum: EA3913DA5334D7E1	FASTA	513	58,860
	10 20 30 40 50 60 MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 70 80 90 100 110 120 ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 130 140 150 160 170 180 PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 250 260 270 280 290 300 VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 310 320 330 340 350 360 NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDTLF SHSVPSSGSP 370 380 390 400 410 420 FITRSMLESS NRLDEEHRLI ARYAARLAAE SSSSQPTQQR SAPDISFTID ANKQQRQLIA 430 440 450 460 470 480 ELENKNREIL QEIQRLRVEH EQASQPTPEK AQQNPTLLAE LRLLRQRKDE LEQRMSALQE 490 500 510 SRRELMVQLE GLMKLLKEEE LKQGVSYVPY CRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein." Blake D.J., Nawrotzki R., Peters M.F., Froehner S.C., Davies K.E. J. Biol. Chem. 271:7802-7810(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 7). Tissue: Brain.
[2]	"Genomic organization of the mouse dystrobrevin gene: comparative analysis with the dystrophin gene." Ambrose H.J., Blake D.J., Nawrotzki R.A., Davies K.E. Genomics 39:359-369(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING. Strain: 129/Sv. Tissue: Brain.
[3]	"Characterisation of alpha-dystrobrevin in muscle." Nawrotzki R., Loh N.Y., Ruegg M.A., Davies K.E., Blake D.J. J. Cell Sci. 111:2595-2605(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Tissue: Muscle.
[4]	"Differential expression and developmental regulation of a novel alpha-dystrobrevin isoform in muscle." Enigk R.E., Maimone M.M. Gene 238:479-488(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 6). Strain: C3H. Tissue: Muscle.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Skin.
[6]	"Interactions between dystrophin glycoprotein complex proteins." Madhavan R., Jarrett H.W. Biochemistry 34:12204-12209(1995) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SNTA1.
[7]	"Differential association of syntrophin pairs with the dystrophin complex." Peters M.F., Adams M.E., Froehner S.C. J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SNTB1.
[8]	"Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain." Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R., Blake D.J. J. Biol. Chem. 276:24232-24241(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DYSTROBREVIN BINDING PROTEIN 1.
[9]	"DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes." Albrecht D.E., Froehner S.C. J. Biol. Chem. 279:7014-7023(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MAGEE1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95226 mRNA. Translation: CAA64518.1. X95227 mRNA. Translation: CAA64519.1. Z79787 , Z79788, Z79789, Z79790, Z79791, Z79792, Z79793, Z79794, Z79795, Z79796, Z79797 Genomic DNA. Translation: CAB02145.1. AJ009669 mRNA. Translation: CAA08770.1. AF143544 mRNA. Translation: AAD33915.1. AF143543 mRNA. Translation: AAD33914.1. AF143542 mRNA. Translation: AAD33913.1. AK019477 mRNA. Translation: BAB31746.1.
IPI	IPI00135042. IPI00222692. IPI00222693. IPI00410809. IPI00466606. IPI00755441. IPI00986293.
RefSeq	NP_034217.2. NM_010087.3.
UniGene	Mm.94371.
3D structure databases
ProteinModelPortal	Q9D2N4.
SMR	Q9D2N4. Positions 26-235, 237-292.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9D2N4. 5 interactions.
MINT	MINT-197169.
PTM databases
PhosphoSite	Q9D2N4.
Proteomic databases
PaxDb	Q9D2N4.
PRIDE	Q9D2N4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302.
GeneID	13527.
KEGG	mmu:13527.
UCSC	uc008efv.1. mouse. uc008efw.1. mouse. uc008efx.1. mouse.
Organism-specific databases
CTD	1837.
MGI	MGI:106039. Dtna.
Phylogenomic databases
eggNOG	NOG251970.
GeneTree	ENSGT00550000074400.
HOVERGEN	HBG005539.
InParanoid	Q9D2N4.
OrthoDB	EOG40GCQ7.
Gene expression databases
ArrayExpress	Q9D2N4.
Bgee	Q9D2N4.
CleanEx	MM_DTNA.
Genevestigator	Q9D2N4.
GermOnline	ENSMUSG00000024302. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR017432. Distrobrevin. IPR011992. EF-hand-like_dom. IPR015153. EF-hand_dom_typ1. IPR015154. EF-hand_dom_typ2. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF09068. efhand_1. 1 hit. PF09069. efhand_2. 1 hit. PF00569. ZZ. 1 hit. [Graphical view]
PIRSF	PIRSF038204. Distrobrevin. 1 hit.
SMART	SM00291. ZnF_ZZ. 1 hit. [Graphical view]
PROSITE	PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	284112.
SOURCE	Search...

Entry information

Entry name

DTNA_MOUSE

Accession

Primary (citable) accession number: Q9D2N4
Secondary accession number(s): P97319 , Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program