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Protein

Ubiquitin-conjugating enzyme E2 variant 2

Gene

Ube2v2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
R-MMU-69473 G2/M DNA damage checkpoint
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 2
Alternative name(s):
Ubc-like protein MMS2
Gene namesi
Name:Ube2v2
Synonyms:Mms2, Uev2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1917870 Ube2v2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000826032 – 145Ubiquitin-conjugating enzyme E2 variant 2Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D2M8
PaxDbiQ9D2M8
PeptideAtlasiQ9D2M8
PRIDEiQ9D2M8

PTM databases

iPTMnetiQ9D2M8
PhosphoSitePlusiQ9D2M8

Expressioni

Gene expression databases

BgeeiENSMUSG00000022674
CleanExiMM_UBE2V2
ExpressionAtlasiQ9D2M8 baseline and differential
GenevisibleiQ9D2M8 MM

Interactioni

Subunit structurei

Heterodimer with UBE2N. Binds CHFR (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214171, 4 interactors
IntActiQ9D2M8, 4 interactors
STRINGi10090.ENSMUSP00000111443

Structurei

3D structure databases

ProteinModelPortaliQ9D2M8
SMRiQ9D2M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0896 Eukaryota
ENOG4111MDW LUCA
GeneTreeiENSGT00740000115534
HOVERGENiHBG054552
InParanoidiQ9D2M8
KOiK10704
OMAiGPARTNY
OrthoDBiEOG091G0SMT
PhylomeDBiQ9D2M8
TreeFamiTF316971

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D2M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI
60 70 80 90 100
IGPPRTNYEN RIYSLKVECG SKYPEAPPSV RFVTKINMNG INNSSGMVDA
110 120 130 140
RSIPVLAKWQ NSYSIKVILQ ELRRLMMSKE NMKLPQPPEG QTYNN
Length:145
Mass (Da):16,367
Last modified:January 23, 2007 - v4
Checksum:i98D63173902C6611
GO
Isoform 2 (identifier: Q9D2M8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-97: Missing.

Show »
Length:103
Mass (Da):11,674
Checksum:i8EF809082980A3DE
GO

Sequence cautioni

The sequence AAH29742 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16L → W in BAC26094 (PubMed:16141072).Curated1
Sequence conflicti38D → N in BAC25968 (PubMed:16141072).Curated1
Sequence conflicti38D → N in BAC27311 (PubMed:16141072).Curated1
Sequence conflicti38D → N in BAC28128 (PubMed:16141072).Curated1
Sequence conflicti38D → N in BAB31753 (PubMed:19468303).Curated1
Sequence conflicti76A → D in AAG22084 (PubMed:11406273).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01152956 – 97Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303828 mRNA Translation: AAG22084.1
AK017786 mRNA Translation: BAB30932.1
AK019486 mRNA Translation: BAB31753.1
AK028472 mRNA Translation: BAC25968.1
AK028742 mRNA Translation: BAC26094.1
AK031233 mRNA Translation: BAC27311.1
AK033016 mRNA Translation: BAC28128.1
CT010522 Genomic DNA No translation available.
BC029742 mRNA Translation: AAH29742.1 Different initiation.
BC058374 mRNA Translation: AAH58374.1
BC083098 mRNA Translation: AAH83098.1
CCDSiCCDS37265.1 [Q9D2M8-1]
CCDS49771.1 [Q9D2M8-2]
RefSeqiNP_001152823.1, NM_001159351.1 [Q9D2M8-2]
NP_076074.2, NM_023585.4 [Q9D2M8-1]
UniGeneiMm.235407
Mm.390775

Genome annotation databases

EnsembliENSMUST00000115776; ENSMUSP00000111442; ENSMUSG00000022674 [Q9D2M8-2]
ENSMUST00000115777; ENSMUSP00000111443; ENSMUSG00000022674 [Q9D2M8-1]
GeneIDi70620
KEGGimmu:70620
UCSCiuc007yhp.2 mouse [Q9D2M8-1]
uc007yhq.2 mouse [Q9D2M8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUB2V2_MOUSE
AccessioniPrimary (citable) accession number: Q9D2M8
Secondary accession number(s): A6X924
, Q8BGH6, Q8CE99, Q8K2V7, Q9CYD7, Q9ERI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 145 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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