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Q9D2M8

- UB2V2_MOUSE

UniProt

Q9D2M8 - UB2V2_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 variant 2

Gene

Ube2v2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.1 Publication

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. error-free postreplication DNA repair Source: MGI

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 2
    Alternative name(s):
    Ubc-like protein MMS2
    Gene namesi
    Name:Ube2v2
    Synonyms:Mms2, Uev2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1917870. Ube2v2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 145144Ubiquitin-conjugating enzyme E2 variant 2PRO_0000082603Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9D2M8.
    PaxDbiQ9D2M8.
    PRIDEiQ9D2M8.

    PTM databases

    PhosphoSiteiQ9D2M8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D2M8.
    BgeeiQ9D2M8.
    CleanExiMM_UBE2V2.
    GenevestigatoriQ9D2M8.

    Interactioni

    Subunit structurei

    Heterodimer with UBE2N. Binds CHFR By similarity.By similarity

    Protein-protein interaction databases

    BioGridi214171. 4 interactions.
    IntActiQ9D2M8. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D2M8.
    SMRiQ9D2M8. Positions 6-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG239185.
    GeneTreeiENSGT00740000115534.
    HOVERGENiHBG054552.
    InParanoidiQ9D2M8.
    KOiK10704.
    OMAiIPILAKW.
    OrthoDBiEOG77M8R5.
    PhylomeDBiQ9D2M8.
    TreeFamiTF316971.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D2M8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI    50
    IGPPRTNYEN RIYSLKVECG SKYPEAPPSV RFVTKINMNG INNSSGMVDA 100
    RSIPVLAKWQ NSYSIKVILQ ELRRLMMSKE NMKLPQPPEG QTYNN 145
    Length:145
    Mass (Da):16,367
    Last modified:January 23, 2007 - v4
    Checksum:i98D63173902C6611
    GO
    Isoform 2 (identifier: Q9D2M8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         56-97: Missing.

    Show »
    Length:103
    Mass (Da):11,674
    Checksum:i8EF809082980A3DE
    GO

    Sequence cautioni

    The sequence AAH29742.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161L → W in BAC26094. (PubMed:16141072)Curated
    Sequence conflicti38 – 381D → N in BAC25968. (PubMed:16141072)Curated
    Sequence conflicti38 – 381D → N in BAC27311. (PubMed:16141072)Curated
    Sequence conflicti38 – 381D → N in BAC28128. (PubMed:16141072)Curated
    Sequence conflicti38 – 381D → N in BAB31753. (PubMed:19468303)Curated
    Sequence conflicti76 – 761A → D in AAG22084. (PubMed:11406273)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei56 – 9742Missing in isoform 2. 1 PublicationVSP_011529Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303828 mRNA. Translation: AAG22084.1.
    AK017786 mRNA. Translation: BAB30932.1.
    AK019486 mRNA. Translation: BAB31753.1.
    AK028472 mRNA. Translation: BAC25968.1.
    AK028742 mRNA. Translation: BAC26094.1.
    AK031233 mRNA. Translation: BAC27311.1.
    AK033016 mRNA. Translation: BAC28128.1.
    CT010522 Genomic DNA. Translation: CAO77942.1.
    BC029742 mRNA. Translation: AAH29742.1. Different initiation.
    BC058374 mRNA. Translation: AAH58374.1.
    BC083098 mRNA. Translation: AAH83098.1.
    CCDSiCCDS37265.1. [Q9D2M8-1]
    CCDS49771.1. [Q9D2M8-2]
    RefSeqiNP_001152823.1. NM_001159351.1. [Q9D2M8-2]
    NP_076074.2. NM_023585.4. [Q9D2M8-1]
    UniGeneiMm.235407.
    Mm.390775.

    Genome annotation databases

    EnsembliENSMUST00000115776; ENSMUSP00000111442; ENSMUSG00000022674. [Q9D2M8-2]
    ENSMUST00000115777; ENSMUSP00000111443; ENSMUSG00000022674. [Q9D2M8-1]
    GeneIDi70620.
    KEGGimmu:70620.
    UCSCiuc007yhp.2. mouse. [Q9D2M8-1]
    uc007yhq.2. mouse. [Q9D2M8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303828 mRNA. Translation: AAG22084.1 .
    AK017786 mRNA. Translation: BAB30932.1 .
    AK019486 mRNA. Translation: BAB31753.1 .
    AK028472 mRNA. Translation: BAC25968.1 .
    AK028742 mRNA. Translation: BAC26094.1 .
    AK031233 mRNA. Translation: BAC27311.1 .
    AK033016 mRNA. Translation: BAC28128.1 .
    CT010522 Genomic DNA. Translation: CAO77942.1 .
    BC029742 mRNA. Translation: AAH29742.1 . Different initiation.
    BC058374 mRNA. Translation: AAH58374.1 .
    BC083098 mRNA. Translation: AAH83098.1 .
    CCDSi CCDS37265.1. [Q9D2M8-1 ]
    CCDS49771.1. [Q9D2M8-2 ]
    RefSeqi NP_001152823.1. NM_001159351.1. [Q9D2M8-2 ]
    NP_076074.2. NM_023585.4. [Q9D2M8-1 ]
    UniGenei Mm.235407.
    Mm.390775.

    3D structure databases

    ProteinModelPortali Q9D2M8.
    SMRi Q9D2M8. Positions 6-145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214171. 4 interactions.
    IntActi Q9D2M8. 3 interactions.

    PTM databases

    PhosphoSitei Q9D2M8.

    Proteomic databases

    MaxQBi Q9D2M8.
    PaxDbi Q9D2M8.
    PRIDEi Q9D2M8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115776 ; ENSMUSP00000111442 ; ENSMUSG00000022674 . [Q9D2M8-2 ]
    ENSMUST00000115777 ; ENSMUSP00000111443 ; ENSMUSG00000022674 . [Q9D2M8-1 ]
    GeneIDi 70620.
    KEGGi mmu:70620.
    UCSCi uc007yhp.2. mouse. [Q9D2M8-1 ]
    uc007yhq.2. mouse. [Q9D2M8-2 ]

    Organism-specific databases

    CTDi 7336.
    MGIi MGI:1917870. Ube2v2.

    Phylogenomic databases

    eggNOGi NOG239185.
    GeneTreei ENSGT00740000115534.
    HOVERGENi HBG054552.
    InParanoidi Q9D2M8.
    KOi K10704.
    OMAi IPILAKW.
    OrthoDBi EOG77M8R5.
    PhylomeDBi Q9D2M8.
    TreeFami TF316971.

    Miscellaneous databases

    NextBioi 331994.
    PROi Q9D2M8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D2M8.
    Bgeei Q9D2M8.
    CleanExi MM_UBE2V2.
    Genevestigatori Q9D2M8.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis."
      Franko J., Ashley C., Xiao W.
      Biochim. Biophys. Acta 1519:70-77(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Embryo, Fetus and Skin.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Embryonic germ cell, Fetal brain and Mammary tumor.

    Entry informationi

    Entry nameiUB2V2_MOUSE
    AccessioniPrimary (citable) accession number: Q9D2M8
    Secondary accession number(s): A6X924
    , Q8BGH6, Q8CE99, Q8K2V7, Q9CYD7, Q9ERI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3