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Q9D2M8

- UB2V2_MOUSE

UniProt

Q9D2M8 - UB2V2_MOUSE

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Protein
Ubiquitin-conjugating enzyme E2 variant 2
Gene
Ube2v2, Mms2, Uev2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.1 Publication

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. error-free postreplication DNA repair Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 2
Alternative name(s):
Ubc-like protein MMS2
Gene namesi
Name:Ube2v2
Synonyms:Mms2, Uev2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1917870. Ube2v2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 145144Ubiquitin-conjugating enzyme E2 variant 2
PRO_0000082603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D2M8.
PaxDbiQ9D2M8.
PRIDEiQ9D2M8.

PTM databases

PhosphoSiteiQ9D2M8.

Expressioni

Gene expression databases

ArrayExpressiQ9D2M8.
BgeeiQ9D2M8.
CleanExiMM_UBE2V2.
GenevestigatoriQ9D2M8.

Interactioni

Subunit structurei

Heterodimer with UBE2N. Binds CHFR By similarity.

Protein-protein interaction databases

BioGridi214171. 4 interactions.
IntActiQ9D2M8. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9D2M8.
SMRiQ9D2M8. Positions 6-145.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG239185.
GeneTreeiENSGT00740000115534.
HOVERGENiHBG054552.
InParanoidiQ9D2M8.
KOiK10704.
OMAiIPILAKW.
OrthoDBiEOG77M8R5.
PhylomeDBiQ9D2M8.
TreeFamiTF316971.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D2M8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI    50
IGPPRTNYEN RIYSLKVECG SKYPEAPPSV RFVTKINMNG INNSSGMVDA 100
RSIPVLAKWQ NSYSIKVILQ ELRRLMMSKE NMKLPQPPEG QTYNN 145
Length:145
Mass (Da):16,367
Last modified:January 23, 2007 - v4
Checksum:i98D63173902C6611
GO
Isoform 2 (identifier: Q9D2M8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-97: Missing.

Show »
Length:103
Mass (Da):11,674
Checksum:i8EF809082980A3DE
GO

Sequence cautioni

The sequence AAH29742.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei56 – 9742Missing in isoform 2.
VSP_011529Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161L → W in BAC26094. 1 Publication
Sequence conflicti38 – 381D → N in BAC25968. 1 Publication
Sequence conflicti38 – 381D → N in BAC27311. 1 Publication
Sequence conflicti38 – 381D → N in BAC28128. 1 Publication
Sequence conflicti38 – 381D → N in BAB31753. 1 Publication
Sequence conflicti76 – 761A → D in AAG22084. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303828 mRNA. Translation: AAG22084.1.
AK017786 mRNA. Translation: BAB30932.1.
AK019486 mRNA. Translation: BAB31753.1.
AK028472 mRNA. Translation: BAC25968.1.
AK028742 mRNA. Translation: BAC26094.1.
AK031233 mRNA. Translation: BAC27311.1.
AK033016 mRNA. Translation: BAC28128.1.
CT010522 Genomic DNA. Translation: CAO77942.1.
BC029742 mRNA. Translation: AAH29742.1. Different initiation.
BC058374 mRNA. Translation: AAH58374.1.
BC083098 mRNA. Translation: AAH83098.1.
CCDSiCCDS37265.1. [Q9D2M8-1]
CCDS49771.1. [Q9D2M8-2]
RefSeqiNP_001152823.1. NM_001159351.1. [Q9D2M8-2]
NP_076074.2. NM_023585.4. [Q9D2M8-1]
UniGeneiMm.235407.
Mm.390775.

Genome annotation databases

EnsembliENSMUST00000115776; ENSMUSP00000111442; ENSMUSG00000022674. [Q9D2M8-2]
ENSMUST00000115777; ENSMUSP00000111443; ENSMUSG00000022674. [Q9D2M8-1]
GeneIDi70620.
KEGGimmu:70620.
UCSCiuc007yhp.2. mouse. [Q9D2M8-1]
uc007yhq.2. mouse. [Q9D2M8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303828 mRNA. Translation: AAG22084.1 .
AK017786 mRNA. Translation: BAB30932.1 .
AK019486 mRNA. Translation: BAB31753.1 .
AK028472 mRNA. Translation: BAC25968.1 .
AK028742 mRNA. Translation: BAC26094.1 .
AK031233 mRNA. Translation: BAC27311.1 .
AK033016 mRNA. Translation: BAC28128.1 .
CT010522 Genomic DNA. Translation: CAO77942.1 .
BC029742 mRNA. Translation: AAH29742.1 . Different initiation.
BC058374 mRNA. Translation: AAH58374.1 .
BC083098 mRNA. Translation: AAH83098.1 .
CCDSi CCDS37265.1. [Q9D2M8-1 ]
CCDS49771.1. [Q9D2M8-2 ]
RefSeqi NP_001152823.1. NM_001159351.1. [Q9D2M8-2 ]
NP_076074.2. NM_023585.4. [Q9D2M8-1 ]
UniGenei Mm.235407.
Mm.390775.

3D structure databases

ProteinModelPortali Q9D2M8.
SMRi Q9D2M8. Positions 6-145.
ModBasei Search...

Protein-protein interaction databases

BioGridi 214171. 4 interactions.
IntActi Q9D2M8. 3 interactions.

PTM databases

PhosphoSitei Q9D2M8.

Proteomic databases

MaxQBi Q9D2M8.
PaxDbi Q9D2M8.
PRIDEi Q9D2M8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115776 ; ENSMUSP00000111442 ; ENSMUSG00000022674 . [Q9D2M8-2 ]
ENSMUST00000115777 ; ENSMUSP00000111443 ; ENSMUSG00000022674 . [Q9D2M8-1 ]
GeneIDi 70620.
KEGGi mmu:70620.
UCSCi uc007yhp.2. mouse. [Q9D2M8-1 ]
uc007yhq.2. mouse. [Q9D2M8-2 ]

Organism-specific databases

CTDi 7336.
MGIi MGI:1917870. Ube2v2.

Phylogenomic databases

eggNOGi NOG239185.
GeneTreei ENSGT00740000115534.
HOVERGENi HBG054552.
InParanoidi Q9D2M8.
KOi K10704.
OMAi IPILAKW.
OrthoDBi EOG77M8R5.
PhylomeDBi Q9D2M8.
TreeFami TF316971.

Miscellaneous databases

NextBioi 331994.
PROi Q9D2M8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9D2M8.
Bgeei Q9D2M8.
CleanExi MM_UBE2V2.
Genevestigatori Q9D2M8.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis."
    Franko J., Ashley C., Xiao W.
    Biochim. Biophys. Acta 1519:70-77(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryo, Fetus and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Embryonic germ cell, Fetal brain and Mammary tumor.

Entry informationi

Entry nameiUB2V2_MOUSE
AccessioniPrimary (citable) accession number: Q9D2M8
Secondary accession number(s): A6X924
, Q8BGH6, Q8CE99, Q8K2V7, Q9CYD7, Q9ERI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 112 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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