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Protein

Adhesion G protein-coupled receptor F4

Gene

Adgrf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

Miscellaneous

Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.034.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor F4
Alternative name(s):
G-protein coupled receptor 115
Gene namesi
Name:Adgrf4
Synonyms:Gpr115
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1925499. Adgrf4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 409ExtracellularCuratedAdd BLAST390
Transmembranei410 – 430Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini431 – 444CytoplasmicCuratedAdd BLAST14
Transmembranei445 – 465Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini466 – 486ExtracellularCuratedAdd BLAST21
Transmembranei487 – 507Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini508 – 518CytoplasmicCuratedAdd BLAST11
Transmembranei519 – 539Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini540 – 566ExtracellularCuratedAdd BLAST27
Transmembranei567 – 587Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini588 – 611CytoplasmicCuratedAdd BLAST24
Transmembranei612 – 632Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini633 – 635ExtracellularCurated3
Transmembranei636 – 656Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini657 – 698CytoplasmicCuratedAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001289520 – 698Adhesion G protein-coupled receptor F4Add BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D2L6.
PaxDbiQ9D2L6.
PRIDEiQ9D2L6.

PTM databases

iPTMnetiQ9D2L6.
PhosphoSitePlusiQ9D2L6.

Expressioni

Tissue specificityi

Expressed in squamous epithelia.1 Publication

Developmental stagei

Expressed during embryonic development in the skin starting at embryonic day 12 with the formation of the basal layer of the skin.1 Publication

Gene expression databases

CleanExiMM_GPR115.

Structurei

3D structure databases

ProteinModelPortaliQ9D2L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 400GPSPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 59Poly-Ser5

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
HOGENOMiHOG000112762.
HOVERGENiHBG051768.
InParanoidiQ9D2L6.
KOiK08457.
PhylomeDBiQ9D2L6.
TreeFamiTF316380.

Family and domain databases

InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiView protein in SMART
SM00303. GPS. 1 hit.
PROSITEiView protein in PROSITE
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D2L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPWIAMVCC LVFFLTTECS HSKPKTHRKD EDKFQISLQK HEFRPRQGKC
60 70 80 90 100
DGLCSSSSSC NQSCPWNFRG EIVFTCNQNK WQKTIETCTS LSVDTLFQRI
110 120 130 140 150
HPAASLSLAS SSVFPMSLIG NAAPVHIGNV FQGIQKYCPE DYVCIVDAVK
160 170 180 190 200
SSAVTSGNIA FIVELLKNIS SNLQTSGIHD NVNWKKMKNY GKVANHILGP
210 220 230 240 250
TAISNWAFIA NKNASSDLLE SVNSFAKKLQ IQGKSESIVD ELFIQTKGSR
260 270 280 290 300
ISHSSSEHSL SLSVPRYNAT EDVLVVIEIP RQALQELSFN ASQAIVVAFP
310 320 330 340 350
TLGAILKEVH RPNTSLQKPI DDLILSLVLP EGLNEIILTF DKINKSQSTS
360 370 380 390 400
SQCVSWDPAT GQWDESPCTV MSDINSTVKC RCRHTKAVTS FSILMSSKPV
410 420 430 440 450
KNTILNHITF IGLSISIFSL VLCLVIEAIV WSRVVVTEIS YMRHVCIVNI
460 470 480 490 500
AVSLLTANVW FIIGSNFSAN VQEDHKWCVA VTFLCHFFFL SLFFWMLFKA
510 520 530 540 550
LLIVYGILVV FRRMMKSRMM AIGFAIGYGC PLVIAVITVT VTEPGEGYTR
560 570 580 590 600
KDACWLNWNQ TKALFAFAIP ALAIVAVNLL VVLAVAINTQ RPLIGSSKSQ
610 620 630 640 650
DMAIVFRISK NVAILTPLLG LTWGFGLTTL LEGVHLVFHI IFALLNAFQG
660 670 680 690
FFILLFGTIM DHKIRDALRM RVSSLKGKSR AAEKVSLSPA NGSRILNR
Length:698
Mass (Da):77,331
Last modified:May 29, 2007 - v2
Checksum:iECC1E777C88E69BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170S → P in AAH89564 (PubMed:15489334).Curated1
Sequence conflicti311R → Q in AAH89564 (PubMed:15489334).Curated1
Sequence conflicti315S → N in BAB31767 (PubMed:16141072).Curated1
Sequence conflicti359A → V in AAH89564 (PubMed:15489334).Curated1
Sequence conflicti489F → L in AAH89564 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019508 mRNA. Translation: BAB31767.1.
BC089564 mRNA. Translation: AAH89564.1.
CCDSiCCDS50113.1.
RefSeqiNP_001276428.1. NM_001289499.1.
NP_001276429.1. NM_001289500.1.
NP_001276430.1. NM_001289501.1.
NP_084343.1. NM_030067.2.
XP_017173214.1. XM_017317725.1.
UniGeneiMm.66217.

Genome annotation databases

GeneIDi78249.
KEGGimmu:78249.
UCSCiuc008cor.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiAGRF4_MOUSE
AccessioniPrimary (citable) accession number: Q9D2L6
Secondary accession number(s): Q5FW81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 29, 2007
Last modified: August 30, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families