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Protein

Adhesion G protein-coupled receptor F4

Gene

Adgrf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.034.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor F4
Alternative name(s):
G-protein coupled receptor 115
Gene namesi
Name:Adgrf4
Synonyms:Gpr115
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1925499. Adgrf4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 409ExtracellularCuratedAdd BLAST390
Transmembranei410 – 430Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini431 – 444CytoplasmicCuratedAdd BLAST14
Transmembranei445 – 465Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini466 – 486ExtracellularCuratedAdd BLAST21
Transmembranei487 – 507Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini508 – 518CytoplasmicCuratedAdd BLAST11
Transmembranei519 – 539Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini540 – 566ExtracellularCuratedAdd BLAST27
Transmembranei567 – 587Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini588 – 611CytoplasmicCuratedAdd BLAST24
Transmembranei612 – 632Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini633 – 635ExtracellularCurated3
Transmembranei636 – 656Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini657 – 698CytoplasmicCuratedAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001289520 – 698Adhesion G protein-coupled receptor F4Add BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi466N-linked (GlcNAc...)Sequence analysis1
Glycosylationi559N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D2L6.
PaxDbiQ9D2L6.
PRIDEiQ9D2L6.

PTM databases

iPTMnetiQ9D2L6.
PhosphoSitePlusiQ9D2L6.

Expressioni

Tissue specificityi

Expressed in squamous epithelia.1 Publication

Developmental stagei

Expressed during embryonic development in the skin starting at embryonic day 12 with the formation of the basal layer of the skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000023918.
CleanExiMM_GPR115.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024711.

Structurei

3D structure databases

ProteinModelPortaliQ9D2L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 400GPSPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 59Poly-Ser5

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
HOGENOMiHOG000112762.
HOVERGENiHBG051768.
InParanoidiQ9D2L6.
KOiK08457.
PhylomeDBiQ9D2L6.
TreeFamiTF316380.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D2L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPWIAMVCC LVFFLTTECS HSKPKTHRKD EDKFQISLQK HEFRPRQGKC
60 70 80 90 100
DGLCSSSSSC NQSCPWNFRG EIVFTCNQNK WQKTIETCTS LSVDTLFQRI
110 120 130 140 150
HPAASLSLAS SSVFPMSLIG NAAPVHIGNV FQGIQKYCPE DYVCIVDAVK
160 170 180 190 200
SSAVTSGNIA FIVELLKNIS SNLQTSGIHD NVNWKKMKNY GKVANHILGP
210 220 230 240 250
TAISNWAFIA NKNASSDLLE SVNSFAKKLQ IQGKSESIVD ELFIQTKGSR
260 270 280 290 300
ISHSSSEHSL SLSVPRYNAT EDVLVVIEIP RQALQELSFN ASQAIVVAFP
310 320 330 340 350
TLGAILKEVH RPNTSLQKPI DDLILSLVLP EGLNEIILTF DKINKSQSTS
360 370 380 390 400
SQCVSWDPAT GQWDESPCTV MSDINSTVKC RCRHTKAVTS FSILMSSKPV
410 420 430 440 450
KNTILNHITF IGLSISIFSL VLCLVIEAIV WSRVVVTEIS YMRHVCIVNI
460 470 480 490 500
AVSLLTANVW FIIGSNFSAN VQEDHKWCVA VTFLCHFFFL SLFFWMLFKA
510 520 530 540 550
LLIVYGILVV FRRMMKSRMM AIGFAIGYGC PLVIAVITVT VTEPGEGYTR
560 570 580 590 600
KDACWLNWNQ TKALFAFAIP ALAIVAVNLL VVLAVAINTQ RPLIGSSKSQ
610 620 630 640 650
DMAIVFRISK NVAILTPLLG LTWGFGLTTL LEGVHLVFHI IFALLNAFQG
660 670 680 690
FFILLFGTIM DHKIRDALRM RVSSLKGKSR AAEKVSLSPA NGSRILNR
Length:698
Mass (Da):77,331
Last modified:May 29, 2007 - v2
Checksum:iECC1E777C88E69BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170S → P in AAH89564 (PubMed:15489334).Curated1
Sequence conflicti311R → Q in AAH89564 (PubMed:15489334).Curated1
Sequence conflicti315S → N in BAB31767 (PubMed:16141072).Curated1
Sequence conflicti359A → V in AAH89564 (PubMed:15489334).Curated1
Sequence conflicti489F → L in AAH89564 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019508 mRNA. Translation: BAB31767.1.
BC089564 mRNA. Translation: AAH89564.1.
CCDSiCCDS50113.1.
RefSeqiNP_001276428.1. NM_001289499.1.
NP_001276429.1. NM_001289500.1.
NP_001276430.1. NM_001289501.1.
NP_084343.1. NM_030067.2.
XP_017173214.1. XM_017317725.1.
UniGeneiMm.66217.

Genome annotation databases

GeneIDi78249.
KEGGimmu:78249.
UCSCiuc008cor.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019508 mRNA. Translation: BAB31767.1.
BC089564 mRNA. Translation: AAH89564.1.
CCDSiCCDS50113.1.
RefSeqiNP_001276428.1. NM_001289499.1.
NP_001276429.1. NM_001289500.1.
NP_001276430.1. NM_001289501.1.
NP_084343.1. NM_030067.2.
XP_017173214.1. XM_017317725.1.
UniGeneiMm.66217.

3D structure databases

ProteinModelPortaliQ9D2L6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024711.

Protein family/group databases

MEROPSiP02.034.
GPCRDBiSearch...

PTM databases

iPTMnetiQ9D2L6.
PhosphoSitePlusiQ9D2L6.

Proteomic databases

MaxQBiQ9D2L6.
PaxDbiQ9D2L6.
PRIDEiQ9D2L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78249.
KEGGimmu:78249.
UCSCiuc008cor.2. mouse.

Organism-specific databases

CTDi221393.
MGIiMGI:1925499. Adgrf4.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
HOGENOMiHOG000112762.
HOVERGENiHBG051768.
InParanoidiQ9D2L6.
KOiK08457.
PhylomeDBiQ9D2L6.
TreeFamiTF316380.

Miscellaneous databases

PROiQ9D2L6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023918.
CleanExiMM_GPR115.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRF4_MOUSE
AccessioniPrimary (citable) accession number: Q9D2L6
Secondary accession number(s): Q5FW81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.