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Protein

Arylsulfatase K

Gene

Arsk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40CalciumBy similarity1
Active sitei80NucleophileBy similarity1
Metal bindingi80Calcium; via 3-oxoalanineBy similarity1
Binding sitei128SubstrateBy similarity1
Binding sitei249SubstrateBy similarity1
Metal bindingi311CalciumBy similarity1
Metal bindingi312CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase K (EC:3.1.6.-)
Short name:
ASK
Gene namesi
Name:Arsk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924291 Arsk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000035628617 – 553Arylsulfatase KAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei803-oxoalanine (Cys)By similarity1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D2L1
PaxDbiQ9D2L1
PRIDEiQ9D2L1

PTM databases

PhosphoSitePlusiQ9D2L1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113274

Structurei

3D structure databases

ProteinModelPortaliQ9D2L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3731 Eukaryota
COG3119 LUCA
HOGENOMiHOG000034080
HOVERGENiHBG054703
InParanoidiQ9D2L1
KOiK12376
PhylomeDBiQ9D2L1
TreeFamiTF313545

Family and domain databases

Gene3Di3.40.720.101 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D2L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLVSVVA ALALAAPAPR TQKKRMQVNQ APNVVLVASD SFDGRLTFQP
60 70 80 90 100
GSQVVKLPFI NFMRAHGTTF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN
110 120 130 140 150
NFKGLDPNYT TWMDIMEKHG YQTQKFGKVD YTSGHHSISN RVEAWTRDVA
160 170 180 190 200
FLLRQEGRPI INLIPDKNRR RVMTKDWQNT DKAIEWLRQV NYTKPFVLYL
210 220 230 240 250
GLNLPHPYPS PSSGENFGSS TFHTSLYWLE KVAYDAIKIP KWLTLSQMHP
260 270 280 290 300
VDFYSSYTKN CTGKFTENEI KNIRAFYYAM CAETDAMLGE IILALHKLDL
310 320 330 340 350
LQKTIVIYTS DHGEMAMEHR QFYKMSMYEA SVHVPLLMMG PGIKANLQVP
360 370 380 390 400
SVVSLVDIYP TMLDIAGIAL PPNLSGYSLL TLLSNASANE QAFKFHRPPW
410 420 430 440 450
ILSEFHGCNA NASTYMLRTG QWKYIAYADG ASVQPQLFDL SLDPDELTNI
460 470 480 490 500
ATEFPEITYS LDQKLRSIVN YPKVSASVHQ YNKEQFIMWK QSVGQNYSNV
510 520 530 540 550
IAHLRWHQDW QRDPRKYENA IQHWLTAHSS PLASSPTQST SGSQPTLPQS

TSG
Length:553
Mass (Da):62,801
Last modified:January 20, 2009 - v2
Checksum:i1C4C405D365EE507
GO

Sequence cautioni

The sequence AAH46790 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH58351 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB28703 differs from that shown. Reason: Frameshift at position 544.Curated
The sequence BAB28703 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB31772 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27279 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC28035 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC29070 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC30444 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC32696 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38801 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC39115 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC39714 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE26079 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE38491 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI84997 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti481Y → H in BAC39714 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046378 mRNA Translation: BAC32696.1 Different initiation.
AK013194 mRNA Translation: BAB28703.1 Sequence problems.
AK086667 mRNA Translation: BAC39714.1 Different initiation.
AK019515 mRNA Translation: BAB31772.1 Different initiation.
AK031147 mRNA Translation: BAC27279.1 Different initiation.
AK032812 mRNA Translation: BAC28035.1 Different initiation.
AK035464 mRNA Translation: BAC29070.1 Different initiation.
AK039765 mRNA Translation: BAC30444.1 Different initiation.
AK083188 mRNA Translation: BAC38801.1 Different initiation.
AK084090 mRNA Translation: BAC39115.1 Different initiation.
AK144817 mRNA Translation: BAE26079.1 Different initiation.
AK165970 mRNA Translation: BAE38491.1 Different initiation.
BC046790 mRNA Translation: AAH46790.3 Different initiation.
BC058351 mRNA Translation: AAH58351.3 Different initiation.
BN000751 mRNA Translation: CAI84997.1 Different initiation.
RefSeqiNP_084123.2, NM_029847.4
UniGeneiMm.196399

Genome annotation databases

GeneIDi77041
KEGGimmu:77041
UCSCiuc007rgh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARSK_MOUSE
AccessioniPrimary (citable) accession number: Q9D2L1
Secondary accession number(s): Q6PE11
, Q8BL50, Q8BUA1, Q9CYZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: March 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome