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Protein

V-set and immunoglobulin domain-containing protein 1

Gene

Vsig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • epithelial cell morphogenesis Source: MGI
  • maintenance of gastrointestinal epithelium Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 1
Alternative name(s):
Cell surface A33 antigen
Glycoprotein A34
Gene namesi
Name:Vsig1
Synonyms:Gpa34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1926039. Vsig1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 234212ExtracellularSequence analysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Topological domaini256 – 407152CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 407385V-set and immunoglobulin domain-containing protein 1PRO_0000313574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi44 ↔ 118PROSITE-ProRule annotation
Disulfide bondi163 ↔ 213PROSITE-ProRule annotation
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence analysis
Modified residuei273 – 2731PhosphoserineCombined sources
Modified residuei274 – 2741PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9D2J4.
PaxDbiQ9D2J4.
PRIDEiQ9D2J4.

PTM databases

iPTMnetiQ9D2J4.
PhosphoSiteiQ9D2J4.

Expressioni

Gene expression databases

CleanExiMM_VSIG1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033806.

Structurei

3D structure databases

ProteinModelPortaliQ9D2J4.
SMRiQ9D2J4. Positions 28-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 134112Ig-like V-typeAdd
BLAST
Domaini145 – 22985Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi323 – 38866Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ9D2J4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 2 hits.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D2J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVFAFWKVF LILNCLAGQV SMVQVTIPDT FVNVTVGSNV TLLCLYTTTE
60 70 80 90 100
KSLEKLSIQW SFFHNKEMEE PISIYYSEGG QASAIGQFKD RIIGATNPGN
110 120 130 140 150
ASITILHMQP ADSGIYICDV NNPPHFVGKN QGLLDVTVLV KPSKPFCTIQ
160 170 180 190 200
GRPEAGHPIS LSCLSAFGTP SPLYYWYNIE GNTIVPVKES FNTATGVLVI
210 220 230 240 250
GNLTNFEQGY YQCTAINSLG NSSCEIDLTS SHPEVGIIIG ALVGALIGAA
260 270 280 290 300
VIICVVYFAR NKVKSKQQKN LNSSTELEPM TKVHHPQQSE AISADGVQLE
310 320 330 340 350
GTLPSSIHAG HNTEPTTTAV LEPEYEPNPP LETTTQPDPE PEGSVPVLAP
360 370 380 390 400
EAEIQPHPEL DPETETEPEP EPEPKPEPEP EPELEPDPQS GVIIEPLSKA

GEDTVKA
Length:407
Mass (Da):44,015
Last modified:June 1, 2001 - v1
Checksum:iB7094F818B868680
GO
Isoform 2 (identifier: Q9D2J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):32,137
Checksum:iD0BDA9A258F22A64
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251H → D in BAB24483 (PubMed:16141072).Curated
Sequence conflicti125 – 1251H → D in BAB24769 (PubMed:16141072).Curated
Sequence conflicti178 – 1781N → K in BAB24483 (PubMed:16141072).Curated
Sequence conflicti178 – 1781N → K in BAB24769 (PubMed:16141072).Curated
Sequence conflicti223 – 2231S → T in BAB24483 (PubMed:16141072).Curated
Sequence conflicti322 – 3221E → K in BAB24769 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_030028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ007336 mRNA. Translation: AAY56125.1.
AK006251 mRNA. Translation: BAB24483.1.
AK006862 mRNA. Translation: BAB24769.1.
AK019565 mRNA. Translation: BAB31795.1.
CCDSiCCDS30443.1. [Q9D2J4-1]
RefSeqiNP_080379.1. NM_026103.1.
UniGeneiMm.244932.

Genome annotation databases

GeneIDi78789.
KEGGimmu:78789.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ007336 mRNA. Translation: AAY56125.1.
AK006251 mRNA. Translation: BAB24483.1.
AK006862 mRNA. Translation: BAB24769.1.
AK019565 mRNA. Translation: BAB31795.1.
CCDSiCCDS30443.1. [Q9D2J4-1]
RefSeqiNP_080379.1. NM_026103.1.
UniGeneiMm.244932.

3D structure databases

ProteinModelPortaliQ9D2J4.
SMRiQ9D2J4. Positions 28-233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033806.

PTM databases

iPTMnetiQ9D2J4.
PhosphoSiteiQ9D2J4.

Proteomic databases

MaxQBiQ9D2J4.
PaxDbiQ9D2J4.
PRIDEiQ9D2J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78789.
KEGGimmu:78789.

Organism-specific databases

CTDi340547.
MGIiMGI:1926039. Vsig1.

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ9D2J4.

Miscellaneous databases

PROiQ9D2J4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_VSIG1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 2 hits.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Glycoprotein A34, a novel target for antibody-based cancer immunotherapy."
    Scanlan M.J., Ritter G., Yin B.W., Williams C. Jr., Cohen L.S., Coplan K.A., Fortunato S.R., Frosina D., Lee S.Y., Murray A.E., Chua R., Filonenko V.V., Sato E., Old L.J., Jungbluth A.A.
    Cancer Immun. 6:2-2(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiVSIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D2J4
Secondary accession number(s): Q9D9J0, Q9DA22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.