Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-set and immunoglobulin domain-containing protein 1

Gene

Vsig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • epithelial cell morphogenesis Source: MGI
  • maintenance of gastrointestinal epithelium Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 1
Alternative name(s):
Cell surface A33 antigen
Glycoprotein A34
Gene namesi
Name:Vsig1
Synonyms:Gpa34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1926039. Vsig1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 234ExtracellularSequence analysisAdd BLAST212
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 407CytoplasmicSequence analysisAdd BLAST152

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031357423 – 407V-set and immunoglobulin domain-containing protein 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi44 ↔ 118PROSITE-ProRule annotation
Disulfide bondi163 ↔ 213PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Modified residuei273PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9D2J4.
PRIDEiQ9D2J4.

PTM databases

iPTMnetiQ9D2J4.
PhosphoSitePlusiQ9D2J4.

Expressioni

Gene expression databases

CleanExiMM_VSIG1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033806.

Structurei

3D structure databases

ProteinModelPortaliQ9D2J4.
SMRiQ9D2J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 134Ig-like V-typeAdd BLAST112
Domaini145 – 229Ig-like C2-typeAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi323 – 388Pro-richAdd BLAST66

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ9D2J4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 2 hits.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D2J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVFAFWKVF LILNCLAGQV SMVQVTIPDT FVNVTVGSNV TLLCLYTTTE
60 70 80 90 100
KSLEKLSIQW SFFHNKEMEE PISIYYSEGG QASAIGQFKD RIIGATNPGN
110 120 130 140 150
ASITILHMQP ADSGIYICDV NNPPHFVGKN QGLLDVTVLV KPSKPFCTIQ
160 170 180 190 200
GRPEAGHPIS LSCLSAFGTP SPLYYWYNIE GNTIVPVKES FNTATGVLVI
210 220 230 240 250
GNLTNFEQGY YQCTAINSLG NSSCEIDLTS SHPEVGIIIG ALVGALIGAA
260 270 280 290 300
VIICVVYFAR NKVKSKQQKN LNSSTELEPM TKVHHPQQSE AISADGVQLE
310 320 330 340 350
GTLPSSIHAG HNTEPTTTAV LEPEYEPNPP LETTTQPDPE PEGSVPVLAP
360 370 380 390 400
EAEIQPHPEL DPETETEPEP EPEPKPEPEP EPELEPDPQS GVIIEPLSKA

GEDTVKA
Length:407
Mass (Da):44,015
Last modified:June 1, 2001 - v1
Checksum:iB7094F818B868680
GO
Isoform 2 (identifier: Q9D2J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):32,137
Checksum:iD0BDA9A258F22A64
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125H → D in BAB24483 (PubMed:16141072).Curated1
Sequence conflicti125H → D in BAB24769 (PubMed:16141072).Curated1
Sequence conflicti178N → K in BAB24483 (PubMed:16141072).Curated1
Sequence conflicti178N → K in BAB24769 (PubMed:16141072).Curated1
Sequence conflicti223S → T in BAB24483 (PubMed:16141072).Curated1
Sequence conflicti322E → K in BAB24769 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0300281 – 107Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ007336 mRNA. Translation: AAY56125.1.
AK006251 mRNA. Translation: BAB24483.1.
AK006862 mRNA. Translation: BAB24769.1.
AK019565 mRNA. Translation: BAB31795.1.
CCDSiCCDS30443.1. [Q9D2J4-1]
RefSeqiNP_080379.1. NM_026103.1.
UniGeneiMm.244932.

Genome annotation databases

GeneIDi78789.
KEGGimmu:78789.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ007336 mRNA. Translation: AAY56125.1.
AK006251 mRNA. Translation: BAB24483.1.
AK006862 mRNA. Translation: BAB24769.1.
AK019565 mRNA. Translation: BAB31795.1.
CCDSiCCDS30443.1. [Q9D2J4-1]
RefSeqiNP_080379.1. NM_026103.1.
UniGeneiMm.244932.

3D structure databases

ProteinModelPortaliQ9D2J4.
SMRiQ9D2J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033806.

PTM databases

iPTMnetiQ9D2J4.
PhosphoSitePlusiQ9D2J4.

Proteomic databases

PaxDbiQ9D2J4.
PRIDEiQ9D2J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78789.
KEGGimmu:78789.

Organism-specific databases

CTDi340547.
MGIiMGI:1926039. Vsig1.

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ9D2J4.

Miscellaneous databases

PROiQ9D2J4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_VSIG1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 2 hits.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D2J4
Secondary accession number(s): Q9D9J0, Q9DA22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.