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Q9D2H6

- SP2_MOUSE

UniProt

Q9D2H6 - SP2_MOUSE

Protein

Transcription factor Sp2

Gene

Sp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri524 – 54825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri554 – 57825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri584 – 60623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cardiovascular system development Source: MGI
    2. embryonic organ development Source: MGI
    3. fibroblast proliferation Source: MGI
    4. in utero embryonic development Source: MGI
    5. multicellular organism growth Source: MGI
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor Sp2
    Gene namesi
    Name:Sp2
    Synonyms:Kiaa0048
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1926162. Sp2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 612612Transcription factor Sp2PRO_0000269192Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei78 – 781PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9D2H6.
    PRIDEiQ9D2H6.

    PTM databases

    PhosphoSiteiQ9D2H6.

    Expressioni

    Gene expression databases

    CleanExiMM_SP2.
    GenevestigatoriQ9D2H6.

    Interactioni

    Protein-protein interaction databases

    BioGridi219700. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D2H6.
    SMRiQ9D2H6. Positions 490-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri524 – 54825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri554 – 57825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri584 – 60623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG008933.
    InParanoidiQ9D2H6.
    KOiK09192.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D2H6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDPQMSMAA TAAVSPSDYL QPAAATTQDS QPSPLALLAA TCSKIGPPAV    50
    EAAVTPPAPP QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ 100
    LSTSYPGGQF VFAIQNPTLI NKGSRSNASI QYQVPQIQGN SSQTIQVQPS 150
    LTNQIQVIPG TNQAITTPST SGHKPVPIKP APVQKSSTTT TPVQSGANVV 200
    KLTGGGSNMT LTLPLNNLVN TSDIGGPAQL LTESPPTPLS KTNKKARKKS 250
    LPVSQPSVAV AEQVETVLIE TTADNIIQAG NNLLIVQSPG GGQPAVVQQV 300
    QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP 350
    TQVYIRTPSG EVQTVLVQDS PPATAATTST VTCNSPALRA PHLSGTSKKH 400
    SAAILRKERP LPKIAPAGSI ISLNAAQLAA AAQAMQTINI NGVQVQGVPV 450
    TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ IQLQMEQALA GEAQPGEKRR 500
    RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL LRAHVRLHTG 550
    ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT 600
    KHYKTHLGTK GL 612
    Length:612
    Mass (Da):64,908
    Last modified:December 12, 2006 - v2
    Checksum:iFF2778DC55B4044F
    GO
    Isoform 2 (identifier: Q9D2H6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: Missing.

    Show »
    Length:605
    Mass (Da):64,131
    Checksum:i2E48ACE7A8EF1B70
    GO

    Sequence cautioni

    The sequence AAH21759.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH86457.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD32155.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61M → T in AAH86457. (PubMed:15489334)Curated
    Sequence conflicti97 – 971Missing in BAD32155. (PubMed:15368895)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77Missing in isoform 2. 1 PublicationVSP_022022

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK172877 Transcribed RNA. Translation: BAD32155.1. Different initiation.
    AK019649 mRNA. Translation: BAB31823.1.
    BC021759 mRNA. Translation: AAH21759.1. Different initiation.
    BC086457 mRNA. Translation: AAH86457.1. Different initiation.
    RefSeqiNP_001074433.1. NM_001080964.1. [Q9D2H6-1]
    NP_084496.2. NM_030220.3.
    UniGeneiMm.491183.

    Genome annotation databases

    GeneIDi78912.
    KEGGimmu:78912.
    UCSCiuc007ldg.1. mouse. [Q9D2H6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK172877 Transcribed RNA. Translation: BAD32155.1 . Different initiation.
    AK019649 mRNA. Translation: BAB31823.1 .
    BC021759 mRNA. Translation: AAH21759.1 . Different initiation.
    BC086457 mRNA. Translation: AAH86457.1 . Different initiation.
    RefSeqi NP_001074433.1. NM_001080964.1. [Q9D2H6-1 ]
    NP_084496.2. NM_030220.3.
    UniGenei Mm.491183.

    3D structure databases

    ProteinModelPortali Q9D2H6.
    SMRi Q9D2H6. Positions 490-610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 219700. 4 interactions.

    PTM databases

    PhosphoSitei Q9D2H6.

    Proteomic databases

    PaxDbi Q9D2H6.
    PRIDEi Q9D2H6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 78912.
    KEGGi mmu:78912.
    UCSCi uc007ldg.1. mouse. [Q9D2H6-1 ]

    Organism-specific databases

    CTDi 6668.
    MGIi MGI:1926162. Sp2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG008933.
    InParanoidi Q9D2H6.
    KOi K09192.

    Miscellaneous databases

    NextBioi 349734.
    PROi Q9D2H6.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SP2.
    Genevestigatori Q9D2H6.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreatic islet.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Eye and Mammary tumor.

    Entry informationi

    Entry nameiSP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9D2H6
    Secondary accession number(s): Q6A0E1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3