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Q9D2H6

- SP2_MOUSE

UniProt

Q9D2H6 - SP2_MOUSE

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Protein

Transcription factor Sp2

Gene
Sp2, Kiaa0048
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri524 – 54825C2H2-type 1Add
BLAST
Zinc fingeri554 – 57825C2H2-type 2Add
BLAST
Zinc fingeri584 – 60623C2H2-type 3Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cardiovascular system development Source: MGI
  2. embryonic organ development Source: MGI
  3. fibroblast proliferation Source: MGI
  4. in utero embryonic development Source: MGI
  5. multicellular organism growth Source: MGI
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp2
Gene namesi
Name:Sp2
Synonyms:Kiaa0048
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1926162. Sp2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Transcription factor Sp2PRO_0000269192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D2H6.
PRIDEiQ9D2H6.

PTM databases

PhosphoSiteiQ9D2H6.

Expressioni

Gene expression databases

CleanExiMM_SP2.
GenevestigatoriQ9D2H6.

Interactioni

Protein-protein interaction databases

BioGridi219700. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9D2H6.
SMRiQ9D2H6. Positions 490-610.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri524 – 54825C2H2-type 1Add
BLAST
Zinc fingeri554 – 57825C2H2-type 2Add
BLAST
Zinc fingeri584 – 60623C2H2-type 3Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG008933.
InParanoidiQ9D2H6.
KOiK09192.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D2H6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDPQMSMAA TAAVSPSDYL QPAAATTQDS QPSPLALLAA TCSKIGPPAV    50
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ 100
LSTSYPGGQF VFAIQNPTLI NKGSRSNASI QYQVPQIQGN SSQTIQVQPS 150
LTNQIQVIPG TNQAITTPST SGHKPVPIKP APVQKSSTTT TPVQSGANVV 200
KLTGGGSNMT LTLPLNNLVN TSDIGGPAQL LTESPPTPLS KTNKKARKKS 250
LPVSQPSVAV AEQVETVLIE TTADNIIQAG NNLLIVQSPG GGQPAVVQQV 300
QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP 350
TQVYIRTPSG EVQTVLVQDS PPATAATTST VTCNSPALRA PHLSGTSKKH 400
SAAILRKERP LPKIAPAGSI ISLNAAQLAA AAQAMQTINI NGVQVQGVPV 450
TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ IQLQMEQALA GEAQPGEKRR 500
RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL LRAHVRLHTG 550
ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT 600
KHYKTHLGTK GL 612
Length:612
Mass (Da):64,908
Last modified:December 12, 2006 - v2
Checksum:iFF2778DC55B4044F
GO
Isoform 2 (identifier: Q9D2H6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:605
Mass (Da):64,131
Checksum:i2E48ACE7A8EF1B70
GO

Sequence cautioni

The sequence AAH21759.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH86457.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD32155.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77Missing in isoform 2. VSP_022022

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61M → T in AAH86457. 1 Publication
Sequence conflicti97 – 971Missing in BAD32155. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK172877 Transcribed RNA. Translation: BAD32155.1. Different initiation.
AK019649 mRNA. Translation: BAB31823.1.
BC021759 mRNA. Translation: AAH21759.1. Different initiation.
BC086457 mRNA. Translation: AAH86457.1. Different initiation.
RefSeqiNP_001074433.1. NM_001080964.1. [Q9D2H6-1]
NP_084496.2. NM_030220.3.
UniGeneiMm.491183.

Genome annotation databases

GeneIDi78912.
KEGGimmu:78912.
UCSCiuc007ldg.1. mouse. [Q9D2H6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK172877 Transcribed RNA. Translation: BAD32155.1 . Different initiation.
AK019649 mRNA. Translation: BAB31823.1 .
BC021759 mRNA. Translation: AAH21759.1 . Different initiation.
BC086457 mRNA. Translation: AAH86457.1 . Different initiation.
RefSeqi NP_001074433.1. NM_001080964.1. [Q9D2H6-1 ]
NP_084496.2. NM_030220.3.
UniGenei Mm.491183.

3D structure databases

ProteinModelPortali Q9D2H6.
SMRi Q9D2H6. Positions 490-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219700. 4 interactions.

PTM databases

PhosphoSitei Q9D2H6.

Proteomic databases

PaxDbi Q9D2H6.
PRIDEi Q9D2H6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 78912.
KEGGi mmu:78912.
UCSCi uc007ldg.1. mouse. [Q9D2H6-1 ]

Organism-specific databases

CTDi 6668.
MGIi MGI:1926162. Sp2.
Rougei Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG008933.
InParanoidi Q9D2H6.
KOi K09192.

Miscellaneous databases

NextBioi 349734.
PROi Q9D2H6.
SOURCEi Search...

Gene expression databases

CleanExi MM_SP2.
Genevestigatori Q9D2H6.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreatic islet.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Eye and Mammary tumor.

Entry informationi

Entry nameiSP2_MOUSE
AccessioniPrimary (citable) accession number: Q9D2H6
Secondary accession number(s): Q6A0E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi