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Q9D2H6 (SP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor Sp2
Gene names
Name:Sp2
Synonyms:Kiaa0048
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence caution

The sequence AAH21759.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH86457.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAD32155.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9D2H6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9D2H6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 612612Transcription factor Sp2
PRO_0000269192

Regions

Zinc finger524 – 54825C2H2-type 1
Zinc finger554 – 57825C2H2-type 2
Zinc finger584 – 60623C2H2-type 3

Amino acid modifications

Modified residue781Phosphoserine By similarity

Natural variations

Alternative sequence1 – 77Missing in isoform 2.
VSP_022022

Experimental info

Sequence conflict61M → T in AAH86457. Ref.3
Sequence conflict971Missing in BAD32155. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: FF2778DC55B4044F

FASTA61264,908
        10         20         30         40         50         60 
MSDPQMSMAA TAAVSPSDYL QPAAATTQDS QPSPLALLAA TCSKIGPPAV EAAVTPPAPP 

        70         80         90        100        110        120 
QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ LSTSYPGGQF VFAIQNPTLI 

       130        140        150        160        170        180 
NKGSRSNASI QYQVPQIQGN SSQTIQVQPS LTNQIQVIPG TNQAITTPST SGHKPVPIKP 

       190        200        210        220        230        240 
APVQKSSTTT TPVQSGANVV KLTGGGSNMT LTLPLNNLVN TSDIGGPAQL LTESPPTPLS 

       250        260        270        280        290        300 
KTNKKARKKS LPVSQPSVAV AEQVETVLIE TTADNIIQAG NNLLIVQSPG GGQPAVVQQV 

       310        320        330        340        350        360 
QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP TQVYIRTPSG 

       370        380        390        400        410        420 
EVQTVLVQDS PPATAATTST VTCNSPALRA PHLSGTSKKH SAAILRKERP LPKIAPAGSI 

       430        440        450        460        470        480 
ISLNAAQLAA AAQAMQTINI NGVQVQGVPV TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ 

       490        500        510        520        530        540 
IQLQMEQALA GEAQPGEKRR RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL 

       550        560        570        580        590        600 
LRAHVRLHTG ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT 

       610 
KHYKTHLGTK GL 

« Hide

Isoform 2 [UniParc].

Checksum: 2E48ACE7A8EF1B70
Show »

FASTA60564,131

References

[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Pancreatic islet.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Eye and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK172877 Transcribed RNA. Translation: BAD32155.1. Different initiation.
AK019649 mRNA. Translation: BAB31823.1.
BC021759 mRNA. Translation: AAH21759.1. Different initiation.
BC086457 mRNA. Translation: AAH86457.1. Different initiation.
RefSeqNP_001074433.1. NM_001080964.1. [Q9D2H6-1]
NP_084496.2. NM_030220.3.
UniGeneMm.491183.

3D structure databases

ProteinModelPortalQ9D2H6.
SMRQ9D2H6. Positions 490-610.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid219700. 4 interactions.

PTM databases

PhosphoSiteQ9D2H6.

Proteomic databases

PaxDbQ9D2H6.
PRIDEQ9D2H6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID78912.
KEGGmmu:78912.
UCSCuc007ldg.1. mouse. [Q9D2H6-1]

Organism-specific databases

CTD6668.
MGIMGI:1926162. Sp2.
RougeSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG008933.
InParanoidQ9D2H6.
KOK09192.

Gene expression databases

CleanExMM_SP2.
GenevestigatorQ9D2H6.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio349734.
PROQ9D2H6.
SOURCESearch...

Entry information

Entry nameSP2_MOUSE
AccessionPrimary (citable) accession number: Q9D2H6
Secondary accession number(s): Q6A0E1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot