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Protein

Transcription factor Sp2

Gene

Sp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri524 – 54825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. histone deacetylase binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. cardiovascular system development Source: MGI
  2. embryonic organ development Source: MGI
  3. fibroblast proliferation Source: MGI
  4. in utero embryonic development Source: MGI
  5. multicellular organism growth Source: MGI
  6. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  7. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp2
Gene namesi
Name:Sp2
Synonyms:Kiaa0048
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1926162. Sp2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Transcription factor Sp2PRO_0000269192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D2H6.
PaxDbiQ9D2H6.
PRIDEiQ9D2H6.

PTM databases

PhosphoSiteiQ9D2H6.

Expressioni

Gene expression databases

CleanExiMM_SP2.
GenevestigatoriQ9D2H6.

Interactioni

Protein-protein interaction databases

BioGridi219700. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9D2H6.
SMRiQ9D2H6. Positions 490-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri524 – 54825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG008933.
InParanoidiQ9D2H6.
KOiK09192.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030451. SP2_TF.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF1. PTHR23235:SF1. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D2H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPQMSMAA TAAVSPSDYL QPAAATTQDS QPSPLALLAA TCSKIGPPAV
60 70 80 90 100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ
110 120 130 140 150
LSTSYPGGQF VFAIQNPTLI NKGSRSNASI QYQVPQIQGN SSQTIQVQPS
160 170 180 190 200
LTNQIQVIPG TNQAITTPST SGHKPVPIKP APVQKSSTTT TPVQSGANVV
210 220 230 240 250
KLTGGGSNMT LTLPLNNLVN TSDIGGPAQL LTESPPTPLS KTNKKARKKS
260 270 280 290 300
LPVSQPSVAV AEQVETVLIE TTADNIIQAG NNLLIVQSPG GGQPAVVQQV
310 320 330 340 350
QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP
360 370 380 390 400
TQVYIRTPSG EVQTVLVQDS PPATAATTST VTCNSPALRA PHLSGTSKKH
410 420 430 440 450
SAAILRKERP LPKIAPAGSI ISLNAAQLAA AAQAMQTINI NGVQVQGVPV
460 470 480 490 500
TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ IQLQMEQALA GEAQPGEKRR
510 520 530 540 550
RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL LRAHVRLHTG
560 570 580 590 600
ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT
610
KHYKTHLGTK GL
Length:612
Mass (Da):64,908
Last modified:December 12, 2006 - v2
Checksum:iFF2778DC55B4044F
GO
Isoform 2 (identifier: Q9D2H6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:605
Mass (Da):64,131
Checksum:i2E48ACE7A8EF1B70
GO

Sequence cautioni

The sequence AAH21759.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH86457.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD32155.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61M → T in AAH86457 (PubMed:15489334).Curated
Sequence conflicti97 – 971Missing in BAD32155 (PubMed:15368895).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77Missing in isoform 2. 1 PublicationVSP_022022

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172877 Transcribed RNA. Translation: BAD32155.1. Different initiation.
AK019649 mRNA. Translation: BAB31823.1.
BC021759 mRNA. Translation: AAH21759.1. Different initiation.
BC086457 mRNA. Translation: AAH86457.1. Different initiation.
RefSeqiNP_001074433.1. NM_001080964.1. [Q9D2H6-1]
NP_084496.2. NM_030220.3.
UniGeneiMm.491183.

Genome annotation databases

GeneIDi78912.
KEGGimmu:78912.
UCSCiuc007ldg.1. mouse. [Q9D2H6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172877 Transcribed RNA. Translation: BAD32155.1. Different initiation.
AK019649 mRNA. Translation: BAB31823.1.
BC021759 mRNA. Translation: AAH21759.1. Different initiation.
BC086457 mRNA. Translation: AAH86457.1. Different initiation.
RefSeqiNP_001074433.1. NM_001080964.1. [Q9D2H6-1]
NP_084496.2. NM_030220.3.
UniGeneiMm.491183.

3D structure databases

ProteinModelPortaliQ9D2H6.
SMRiQ9D2H6. Positions 490-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219700. 4 interactions.

PTM databases

PhosphoSiteiQ9D2H6.

Proteomic databases

MaxQBiQ9D2H6.
PaxDbiQ9D2H6.
PRIDEiQ9D2H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78912.
KEGGimmu:78912.
UCSCiuc007ldg.1. mouse. [Q9D2H6-1]

Organism-specific databases

CTDi6668.
MGIiMGI:1926162. Sp2.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG008933.
InParanoidiQ9D2H6.
KOiK09192.

Miscellaneous databases

NextBioi349734.
PROiQ9D2H6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SP2.
GenevestigatoriQ9D2H6.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030451. SP2_TF.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF1. PTHR23235:SF1. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreatic islet.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Eye and Mammary tumor.

Entry informationi

Entry nameiSP2_MOUSE
AccessioniPrimary (citable) accession number: Q9D2H6
Secondary accession number(s): Q6A0E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: April 1, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.