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Protein

Tripartite motif-containing protein 42

Gene

Trim42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 42
Gene namesi
Name:Trim42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926161. Trim42.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Tripartite motif-containing protein 42PRO_0000056264Add
BLAST

Proteomic databases

PaxDbiQ9D2H5.
PRIDEiQ9D2H5.

PTM databases

iPTMnetiQ9D2H5.
PhosphoSiteiQ9D2H5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032451.
CleanExiMM_TRIM42.
GenevisibleiQ9D2H5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035026.

Structurei

3D structure databases

ProteinModelPortaliQ9D2H5.
SMRiQ9D2H5. Positions 236-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 49259COSPROSITE-ProRule annotationAdd
BLAST
Domaini603 – 70199Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili382 – 41231Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 9691Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF3. Eukaryota.
ENOG410YJTN. LUCA.
GeneTreeiENSGT00530000064220.
HOGENOMiHOG000168411.
HOVERGENiHBG056782.
InParanoidiQ9D2H5.
KOiK12018.
OMAiRLTKRYM.
OrthoDBiEOG091G02EW.
TreeFamiTF336556.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D2H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAMCVCSP CCTWQRCCPR LFSCLCCKFI FTSERNCTCF PCPYKDERNC
60 70 80 90 100
QFCHCTCAEN PNCHWCCCSW ANDPNCKCCC TASTNLKCYY YESHCCRNVT
110 120 130 140 150
ITFRKGRLRS IVTSSKTALR VGSSDTQMDE PKTMPASSHL VSHLTCPMCN
160 170 180 190 200
RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPM CSRSHCMPYS
210 220 230 240 250
HQMHLPENYL RGRLTKRYMQ QHGYLKWRFD RSSGPILCQV CRTRRIAYKR
260 270 280 290 300
CVTCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEDQDEKIC IHHPSSRINE
310 320 330 340 350
YCRSDNQLLC AFCKIAFHNG HDTVSLIDAC SERSAALFSA IAKFKAVRYE
360 370 380 390 400
IDNDLMEFNI LKSSFKADKE AKRKEVRNGF LKLRAILQEK EKIIMEQIEN
410 420 430 440 450
LEVSRQKEIE KYVYITTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV
460 470 480 490 500
DQIEEGIQNT FRPDPQLRLH SLHCIPLDFA ELSNAIHELF PTGPKKACSS
510 520 530 540 550
GDSLPSQYPI HSEMMIARKV TFSTHSFGNQ QIYQRSSSLI SFNTANDKGK
560 570 580 590 600
MGLENYGRAQ SAAPAKTTDG LYTYWSATGE TQPPQSSNSF HNWYSFNDTS
610 620 630 640 650
VRTPGPIVIY QTLVYPRAAK VYWTCPTEDV DSFEMEFYEL VTTPPNNVRT
660 670 680 690 700
ELCGQIRDIL QQNLELHNLT PNTEYLFKVR AINDNGPGQW SDICKVVTPD
710 720
GRGKNRAKWG LLKNIQSALQ KRF
Length:723
Mass (Da):82,953
Last modified:July 27, 2011 - v2
Checksum:i0F6BCD01888E70B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti679 – 6791V → I in BAB31824 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019654 mRNA. Translation: BAB31824.1.
AC126931 Genomic DNA. No translation available.
CCDSiCCDS23422.1.
RefSeqiNP_084495.2. NM_030219.2.
UniGeneiMm.108347.

Genome annotation databases

EnsembliENSMUST00000035026; ENSMUSP00000035026; ENSMUSG00000032451.
GeneIDi78911.
KEGGimmu:78911.
UCSCiuc009rdc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019654 mRNA. Translation: BAB31824.1.
AC126931 Genomic DNA. No translation available.
CCDSiCCDS23422.1.
RefSeqiNP_084495.2. NM_030219.2.
UniGeneiMm.108347.

3D structure databases

ProteinModelPortaliQ9D2H5.
SMRiQ9D2H5. Positions 236-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035026.

PTM databases

iPTMnetiQ9D2H5.
PhosphoSiteiQ9D2H5.

Proteomic databases

PaxDbiQ9D2H5.
PRIDEiQ9D2H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035026; ENSMUSP00000035026; ENSMUSG00000032451.
GeneIDi78911.
KEGGimmu:78911.
UCSCiuc009rdc.1. mouse.

Organism-specific databases

CTDi287015.
MGIiMGI:1926161. Trim42.

Phylogenomic databases

eggNOGiENOG410ITF3. Eukaryota.
ENOG410YJTN. LUCA.
GeneTreeiENSGT00530000064220.
HOGENOMiHOG000168411.
HOVERGENiHBG056782.
InParanoidiQ9D2H5.
KOiK12018.
OMAiRLTKRYM.
OrthoDBiEOG091G02EW.
TreeFamiTF336556.

Miscellaneous databases

PROiQ9D2H5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032451.
CleanExiMM_TRIM42.
GenevisibleiQ9D2H5. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI42_MOUSE
AccessioniPrimary (citable) accession number: Q9D2H5
Secondary accession number(s): E9QN55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.