Reviewed, UniProtKB/Swiss-Prot Q9D2G5 (SYNJ2_MOUSE)

Names and origin

Protein names

Recommended name:
    Synaptojanin-2
    EC=3.1.3.36
Alternative name(s):
    Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2

Gene names

Name:	Synj2
Synonyms:	Kiaa0348

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis By similarity. Ref.5
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Subunit structure	Binds GRB2 and OMP25 By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Ubiquitously expressed, with the highest levels in heart and brain. Detected in cortex, cerebellum and olfactory bulb. Expressed in the testis. Ref.5 Ref.6
Domain	The C-terminal proline-rich region mediates binding to the SH3 domain-containing protein GRB2.
Sequence similarities	Belongs to the synaptojanin family. In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SAC domain.
Sequence caution	The sequence AAC33137.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAC33137.1 differs from that shown. Reason: Miscellaneous discrepancy. Sequencing errors.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	RNA-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Ref.5 Inferred from direct assay. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9D2G5-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9D2G5-2) The sequence of this isoform differs from the canonical sequence as follows:      1-85: Missing.
Note: No experimental confirmation available.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Natural variant	94	1	N → D
	Natural variant	385	1	S → F
Isoform 3 (identifier: Q9D2G5-3) The sequence of this isoform differs from the canonical sequence as follows:      1-316: Missing.      317-318: FK → MQ      1106-1434: PKARTGISKP...NKDKRTTLGV → VSPLWGSQGSGQRFRPAGVVLHPKTMWISVDTRNI
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9D2G5-4) The sequence of this isoform differs from the canonical sequence as follows:      1-161: Missing.      162-162: W → M
Note: No experimental confirmation available.
Isoform 5 (identifier: Q9D2G5-5) The sequence of this isoform differs from the canonical sequence as follows:      1192-1434: PMLPEENFEP...NKDKRTTLGV → VYSGISQCLR...FQDLWLKFRR
Isoform 6 (identifier: Q9D2G5-6) Also known as: 2alpha; The sequence of this isoform differs from the canonical sequence as follows:      1-85: Missing.      1068-1068: A → DDAHLVTLKQELEVAGNFRHRSPSRSLSVPNRPRPPHPPQRPPPPT      1192-1434: PMLPEENFEP...NKDKRTTLGV → VYSGISQCLR...FQDLWLKFRR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1434	1434	Synaptojanin-2		PRO_0000209734
Regions
	Domain	120 – 444	325	SAC
	Domain	889 – 968	80	RRM
	Region	450 – ?		Catalytic By similarity
	Compositional bias	1144 – 1281	138	Pro-rich
Amino acid modifications
	Modified residue	130	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	1 – 316	316	Missing in isoform 3.		VSP_009306
	Alternative sequence	1 – 161	161	Missing in isoform 4.		VSP_009305
	Alternative sequence	1 – 85	85	Missing in isoform 2 and isoform 6.		VSP_009304
	Alternative sequence	162	1	W → M in isoform 4.		VSP_010563
	Alternative sequence	317 – 318	2	FK → MQ in isoform 3.		VSP_009307
	Alternative sequence	1068	1	A → DDAHLVTLKQELEVAGNFRH RSPSRSLSVPNRPRPPHPPQ RPPPPT in isoform 6.		VSP_009308
	Alternative sequence	1106 – 1434	329	PKART…TTLGV → VSPLWGSQGSGQRFRPAGVV LHPKTMWISVDTRNI in isoform 3.		VSP_009309
	Alternative sequence	1192 – 1434	243	PMLPE…TTLGV → VYSGISQCLREELRSAACTP HAVSAQDCGDLNNRWRMPRF SHYIHTKKWKNVSLSFQDLW LKFRR in isoform 5 and isoform 6.		VSP_009310
	Natural variant	263	1	G → R
	Natural variant	278	1	E → G
	Natural variant	304	1	L → P
Experimental info
	Sequence conflict	571	1	S → Y in BAB31837. Ref.3
	Sequence conflict	1013 – 1019	7	DVLEEDE → MFLKRMK in AAC40144. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 16, 2004. Version 2. Checksum: 69FE8148A3E91827	FASTA	1,434	158,480
	10 20 30 40 50 60 MALSKGLRLL ARLDPTGPSS VLLEARGRGD CLLFEAGAVA TLAPEEKEVI KGLYSKLTDA 70 80 90 100 110 120 YGCLGELRLQ SGGVPLSFLV LVTGCMSVGR IPDAEIYKIT ATELYPLQEE AKEEDRLPTL 130 140 150 160 170 180 KKILSSGVFY FAWPNDGACF DLTIRAQKQG DDGSEWGTSF FWNQLLHVPL RQHQVNCHNW 190 200 210 220 230 240 LLKVICGVVT IRTVYASHKQ AKACLISRIS CERAGARFLT RGVNDDGHVS NFVETEQTIY 250 260 270 280 290 300 MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFERHMVL LKEQYGKQVV 310 320 330 340 350 360 VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGRKLEKLE NLLRPQLQLH 370 380 390 400 410 420 WEDFGVFAKG ENVSPRFQKG TLRMNCLDCL DRTNTVQCFI ALEVLHLQLE SLGLNSKPII 430 440 450 460 470 480 DRFVESFKAM WSLNGHSLSK VFTGSRALEG KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA 490 500 510 520 530 540 IKLLLVGDVY NEESTDKGRM LLDNTALLAT PRILKAMTER QSEFTNFKRI QIAVGTWNVN 550 560 570 580 590 600 GGKQFRSNLL GTAELTDWLL DAPQLSGAVD SQDDGSPADV FAIGFEEMVE LSAGNIVNAS 610 620 630 640 650 660 TTNRKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA IDTVKTGMGG 670 680 690 700 710 720 KAGNKGAVGI RFQLHSTSFC FVCSHLTAGQ SQVKERNEDY REITHKLSFP SGRNIFSHDY 730 740 750 760 770 780 VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL MEFDQLQLQK SSGKIFKDFH EGAVNFGPTY 790 800 810 820 830 840 KYDVGSAAYD TSDKCRTPAW TDRVLWWRKK HPYDKTAGEL NLLDSDLDGD PQIRHTWSPG 850 860 870 880 890 900 TLKYYGRAEL QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSVQGPLDA TVVVNLQSPT 910 920 930 940 950 960 LEEKNEFPED LRTELMQTLG NYGTIILVRI NQGQMLVTFA DSHSALSVLD VDGMKVKGRA 970 980 990 1000 1010 1020 VKIRPKTKDW LEGLREELLR KRDSMAPVSP TANSCLLEEN FDFSSLDYES EGDVLEEDED 1030 1040 1050 1060 1070 1080 YLVDGFGQPV VSDSELGGDN SSDTMSSLTP ASKSPALAKK KQHPTYKAGL MVKKSASDAS 1090 1100 1110 1120 1130 1140 ISSGTHGQYS ILQTAKLLPG APQQPPKART GISKPYNVKQ IKTTNAQEAE AAIRCLLEAS 1150 1160 1170 1180 1190 1200 GGVPESAPGA IPLRNQGSSK PEATLGPPAL PRRPAPRVPT MKKPTLRRTG KPMLPEENFE 1210 1220 1230 1240 1250 1260 PQPVHFTMAS QEMNLETPPP ITATPIPPVP KPRTLQPGKG VEGRPSSGKP EPDEAPSVTG 1270 1280 1290 1300 1310 1320 TVESPPPEAQ EAPSLAPKVP PRRKKSAPAA FHLQVLQNNS QVLQGLTCSS SSPPSLKPDT 1330 1340 1350 1360 1370 1380 HPLCLQVALG TSSARSPETH GPRVTEPEAA SFHGNYPDPF WSLLHHPKLL NNTWLSKSSE 1390 1400 1410 1420 1430 PLDVGSRNPE RTHTEPAQVN ASLAERGLPP DHGGKDLSHW VTASNKDKRT TLGV
	Isoform 2. Checksum: 32F9E3FDA32C98EE	FASTA	1,349	149,621
	10 20 30 40 50 60 MSVGRIPDAE IYKITATELY PLQEEAKEED RLPTLKKILS SGVFYFAWPN DGACFDLTIR 70 80 90 100 110 120 AQKQGDDGSE WGTSFFWNQL LHVPLRQHQV NCHNWLLKVI CGVVTIRTVY ASHKQAKACL 130 140 150 160 170 180 ISRISCERAG ARFLTRGVND DGHVSNFVET EQTIYMDDGV SSFVQIRGSV PLFWEQPGLQ 190 200 210 220 230 240 VGSHHLRLHR GLEANAPAFE RHMVLLKEQY GKQVVVNLLG SRGGEEVLNR AFKKLLWASC 250 260 270 280 290 300 HAGDTPMINF DFHQFAKGRK LEKLENLLRP QLQLHWEDFG VFAKGENVSP RFQKGTLRMN 310 320 330 340 350 360 CLDCLDRTNT VQCFIALEVL HLQLESLGLN SKPIIDRFVE SFKAMWSLNG HSLSKVFTGS 370 380 390 400 410 420 RALEGKAKVG KLKDGARSMS RTIQSNFFDG VKQEAIKLLL VGDVYNEEST DKGRMLLDNT 430 440 450 460 470 480 ALLATPRILK AMTERQSEFT NFKRIQIAVG TWNVNGGKQF RSNLLGTAEL TDWLLDAPQL 490 500 510 520 530 540 SGAVDSQDDG SPADVFAIGF EEMVELSAGN IVNASTTNRK MWGEQLQKAI SRSHRYILLT 550 560 570 580 590 600 SAQLVGVCLY IFVRPYHVPF IRDVAIDTVK TGMGGKAGNK GAVGIRFQLH STSFCFVCSH 610 620 630 640 650 660 LTAGQSQVKE RNEDYREITH KLSFPSGRNI FSHDYVFWCG DFNYRIDLTY EEVFYFVKRQ 670 680 690 700 710 720 DWKKLMEFDQ LQLQKSSGKI FKDFHEGAVN FGPTYKYDVG SAAYDTSDKC RTPAWTDRVL 730 740 750 760 770 780 WWRKKHPYDK TAGELNLLDS DLDGDPQIRH TWSPGTLKYY GRAELQASDH RPVLAIVEVE 790 800 810 820 830 840 VQEVDVGARE RVFQEVSSVQ GPLDATVVVN LQSPTLEEKN EFPEDLRTEL MQTLGNYGTI 850 860 870 880 890 900 ILVRINQGQM LVTFADSHSA LSVLDVDGMK VKGRAVKIRP KTKDWLEGLR EELLRKRDSM 910 920 930 940 950 960 APVSPTANSC LLEENFDFSS LDYESEGDVL EEDEDYLVDG FGQPVVSDSE LGGDNSSDTM 970 980 990 1000 1010 1020 SSLTPASKSP ALAKKKQHPT YKAGLMVKKS ASDASISSGT HGQYSILQTA KLLPGAPQQP 1030 1040 1050 1060 1070 1080 PKARTGISKP YNVKQIKTTN AQEAEAAIRC LLEASGGVPE SAPGAIPLRN QGSSKPEATL 1090 1100 1110 1120 1130 1140 GPPALPRRPA PRVPTMKKPT LRRTGKPMLP EENFEPQPVH FTMASQEMNL ETPPPITATP 1150 1160 1170 1180 1190 1200 IPPVPKPRTL QPGKGVEGRP SSGKPEPDEA PSVTGTVESP PPEAQEAPSL APKVPPRRKK 1210 1220 1230 1240 1250 1260 SAPAAFHLQV LQNNSQVLQG LTCSSSSPPS LKPDTHPLCL QVALGTSSAR SPETHGPRVT 1270 1280 1290 1300 1310 1320 EPEAASFHGN YPDPFWSLLH HPKLLNNTWL SKSSEPLDVG SRNPERTHTE PAQVNASLAE 1330 1340 RGLPPDHGGK DLSHWVTASN KDKRTTLGV
	Isoform 3. Checksum: BCE381F62FB82850	FASTA	824	92,285
	10 20 30 40 50 60 MQKLLWASCH AGDTPMINFD FHQFAKGRKL EKLENLLRPQ LQLHWEDFGV FAKGENVSPR 70 80 90 100 110 120 FQKGTLRMNC LDCLDRTNTV QCFIALEVLH LQLESLGLNS KPIIDRFVES FKAMWSLNGH 130 140 150 160 170 180 SLSKVFTGSR ALEGKAKVGK LKDGARSMSR TIQSNFFDGV KQEAIKLLLV GDVYNEESTD 190 200 210 220 230 240 KGRMLLDNTA LLATPRILKA MTERQSEFTN FKRIQIAVGT WNVNGGKQFR SNLLGTAELT 250 260 270 280 290 300 DWLLDAPQLS GAVDSQDDGS PADVFAIGFE EMVELSAGNI VNASTTNRKM WGEQLQKAIS 310 320 330 340 350 360 RSHRYILLTS AQLVGVCLYI FVRPYHVPFI RDVAIDTVKT GMGGKAGNKG AVGIRFQLHS 370 380 390 400 410 420 TSFCFVCSHL TAGQSQVKER NEDYREITHK LSFPSGRNIF SHDYVFWCGD FNYRIDLTYE 430 440 450 460 470 480 EVFYFVKRQD WKKLMEFDQL QLQKSSGKIF KDFHEGAVNF GPTYKYDVGS AAYDTSDKCR 490 500 510 520 530 540 TPAWTDRVLW WRKKHPYDKT AGELNLLDSD LDGDPQIRHT WSPGTLKYYG RAELQASDHR 550 560 570 580 590 600 PVLAIVEVEV QEVDVGARER VFQEVSSVQG PLDATVVVNL QSPTLEEKNE FPEDLRTELM 610 620 630 640 650 660 QTLGNYGTII LVRINQGQML VTFADSHSAL SVLDVDGMKV KGRAVKIRPK TKDWLEGLRE 670 680 690 700 710 720 ELLRKRDSMA PVSPTANSCL LEENFDFSSL DYESEGDVLE EDEDYLVDGF GQPVVSDSEL 730 740 750 760 770 780 GGDNSSDTMS SLTPASKSPA LAKKKQHPTY KAGLMVKKSA SDASISSGTH GQYSILQTAK 790 800 810 820 LLPGAPQQPV SPLWGSQGSG QRFRPAGVVL HPKTMWISVD TRNI
	Isoform 4. Checksum: E9ADB182F47FC406	FASTA	1,273	140,990
	10 20 30 40 50 60 MNQLLHVPLR QHQVNCHNWL LKVICGVVTI RTVYASHKQA KACLISRISC ERAGARFLTR 70 80 90 100 110 120 GVNDDGHVSN FVETEQTIYM DDGVSSFVQI RGSVPLFWEQ PGLQVGSHHL RLHRGLEANA 130 140 150 160 170 180 PAFERHMVLL KEQYGKQVVV NLLGSRGGEE VLNRAFKKLL WASCHAGDTP MINFDFHQFA 190 200 210 220 230 240 KGRKLEKLEN LLRPQLQLHW EDFGVFAKGE NVSPRFQKGT LRMNCLDCLD RTNTVQCFIA 250 260 270 280 290 300 LEVLHLQLES LGLNSKPIID RFVESFKAMW SLNGHSLSKV FTGSRALEGK AKVGKLKDGA 310 320 330 340 350 360 RSMSRTIQSN FFDGVKQEAI KLLLVGDVYN EESTDKGRML LDNTALLATP RILKAMTERQ 370 380 390 400 410 420 SEFTNFKRIQ IAVGTWNVNG GKQFRSNLLG TAELTDWLLD APQLSGAVDS QDDGSPADVF 430 440 450 460 470 480 AIGFEEMVEL SAGNIVNAST TNRKMWGEQL QKAISRSHRY ILLTSAQLVG VCLYIFVRPY 490 500 510 520 530 540 HVPFIRDVAI DTVKTGMGGK AGNKGAVGIR FQLHSTSFCF VCSHLTAGQS QVKERNEDYR 550 560 570 580 590 600 EITHKLSFPS GRNIFSHDYV FWCGDFNYRI DLTYEEVFYF VKRQDWKKLM EFDQLQLQKS 610 620 630 640 650 660 SGKIFKDFHE GAVNFGPTYK YDVGSAAYDT SDKCRTPAWT DRVLWWRKKH PYDKTAGELN 670 680 690 700 710 720 LLDSDLDGDP QIRHTWSPGT LKYYGRAELQ ASDHRPVLAI VEVEVQEVDV GARERVFQEV 730 740 750 760 770 780 SSVQGPLDAT VVVNLQSPTL EEKNEFPEDL RTELMQTLGN YGTIILVRIN QGQMLVTFAD 790 800 810 820 830 840 SHSALSVLDV DGMKVKGRAV KIRPKTKDWL EGLREELLRK RDSMAPVSPT ANSCLLEENF 850 860 870 880 890 900 DFSSLDYESE GDVLEEDEDY LVDGFGQPVV SDSELGGDNS SDTMSSLTPA SKSPALAKKK 910 920 930 940 950 960 QHPTYKAGLM VKKSASDASI SSGTHGQYSI LQTAKLLPGA PQQPPKARTG ISKPYNVKQI 970 980 990 1000 1010 1020 KTTNAQEAEA AIRCLLEASG GVPESAPGAI PLRNQGSSKP EATLGPPALP RRPAPRVPTM 1030 1040 1050 1060 1070 1080 KKPTLRRTGK PMLPEENFEP QPVHFTMASQ EMNLETPPPI TATPIPPVPK PRTLQPGKGV 1090 1100 1110 1120 1130 1140 EGRPSSGKPE PDEAPSVTGT VESPPPEAQE APSLAPKVPP RRKKSAPAAF HLQVLQNNSQ 1150 1160 1170 1180 1190 1200 VLQGLTCSSS SPPSLKPDTH PLCLQVALGT SSARSPETHG PRVTEPEAAS FHGNYPDPFW 1210 1220 1230 1240 1250 1260 SLLHHPKLLN NTWLSKSSEP LDVGSRNPER THTEPAQVNA SLAERGLPPD HGGKDLSHWV 1270 TASNKDKRTT LGV
	Isoform 5. Checksum: 4C6B04FBA36CAF2D	FASTA	1,256	140,129
	10 20 30 40 50 60 MALSKGLRLL ARLDPTGPSS VLLEARGRGD CLLFEAGAVA TLAPEEKEVI KGLYSKLTDA 70 80 90 100 110 120 YGCLGELRLQ SGGVPLSFLV LVTGCMSVGR IPDAEIYKIT ATELYPLQEE AKEEDRLPTL 130 140 150 160 170 180 KKILSSGVFY FAWPNDGACF DLTIRAQKQG DDGSEWGTSF FWNQLLHVPL RQHQVNCHNW 190 200 210 220 230 240 LLKVICGVVT IRTVYASHKQ AKACLISRIS CERAGARFLT RGVNDDGHVS NFVETEQTIY 250 260 270 280 290 300 MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFERHMVL LKEQYGKQVV 310 320 330 340 350 360 VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGRKLEKLE NLLRPQLQLH 370 380 390 400 410 420 WEDFGVFAKG ENVSPRFQKG TLRMNCLDCL DRTNTVQCFI ALEVLHLQLE SLGLNSKPII 430 440 450 460 470 480 DRFVESFKAM WSLNGHSLSK VFTGSRALEG KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA 490 500 510 520 530 540 IKLLLVGDVY NEESTDKGRM LLDNTALLAT PRILKAMTER QSEFTNFKRI QIAVGTWNVN 550 560 570 580 590 600 GGKQFRSNLL GTAELTDWLL DAPQLSGAVD SQDDGSPADV FAIGFEEMVE LSAGNIVNAS 610 620 630 640 650 660 TTNRKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA IDTVKTGMGG 670 680 690 700 710 720 KAGNKGAVGI RFQLHSTSFC FVCSHLTAGQ SQVKERNEDY REITHKLSFP SGRNIFSHDY 730 740 750 760 770 780 VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL MEFDQLQLQK SSGKIFKDFH EGAVNFGPTY 790 800 810 820 830 840 KYDVGSAAYD TSDKCRTPAW TDRVLWWRKK HPYDKTAGEL NLLDSDLDGD PQIRHTWSPG 850 860 870 880 890 900 TLKYYGRAEL QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSVQGPLDA TVVVNLQSPT 910 920 930 940 950 960 LEEKNEFPED LRTELMQTLG NYGTIILVRI NQGQMLVTFA DSHSALSVLD VDGMKVKGRA 970 980 990 1000 1010 1020 VKIRPKTKDW LEGLREELLR KRDSMAPVSP TANSCLLEEN FDFSSLDYES EGDVLEEDED 1030 1040 1050 1060 1070 1080 YLVDGFGQPV VSDSELGGDN SSDTMSSLTP ASKSPALAKK KQHPTYKAGL MVKKSASDAS 1090 1100 1110 1120 1130 1140 ISSGTHGQYS ILQTAKLLPG APQQPPKART GISKPYNVKQ IKTTNAQEAE AAIRCLLEAS 1150 1160 1170 1180 1190 1200 GGVPESAPGA IPLRNQGSSK PEATLGPPAL PRRPAPRVPT MKKPTLRRTG KVYSGISQCL 1210 1220 1230 1240 1250 REELRSAACT PHAVSAQDCG DLNNRWRMPR FSHYIHTKKW KNVSLSFQDL WLKFRR
	Isoform 6 (2alpha). Checksum: 8093BE1D6419C728	FASTA	1,216	136,363
	10 20 30 40 50 60 MSVGRIPDAE IYKITATELY PLQEEAKEED RLPTLKKILS SGVFYFAWPN DGACFDLTIR 70 80 90 100 110 120 AQKQGDDGSE WGTSFFWNQL LHVPLRQHQV NCHNWLLKVI CGVVTIRTVY ASHKQAKACL 130 140 150 160 170 180 ISRISCERAG ARFLTRGVND DGHVSNFVET EQTIYMDDGV SSFVQIRGSV PLFWEQPGLQ 190 200 210 220 230 240 VGSHHLRLHR GLEANAPAFE RHMVLLKEQY GKQVVVNLLG SRGGEEVLNR AFKKLLWASC 250 260 270 280 290 300 HAGDTPMINF DFHQFAKGRK LEKLENLLRP QLQLHWEDFG VFAKGENVSP RFQKGTLRMN 310 320 330 340 350 360 CLDCLDRTNT VQCFIALEVL HLQLESLGLN SKPIIDRFVE SFKAMWSLNG HSLSKVFTGS 370 380 390 400 410 420 RALEGKAKVG KLKDGARSMS RTIQSNFFDG VKQEAIKLLL VGDVYNEEST DKGRMLLDNT 430 440 450 460 470 480 ALLATPRILK AMTERQSEFT NFKRIQIAVG TWNVNGGKQF RSNLLGTAEL TDWLLDAPQL 490 500 510 520 530 540 SGAVDSQDDG SPADVFAIGF EEMVELSAGN IVNASTTNRK MWGEQLQKAI SRSHRYILLT 550 560 570 580 590 600 SAQLVGVCLY IFVRPYHVPF IRDVAIDTVK TGMGGKAGNK GAVGIRFQLH STSFCFVCSH 610 620 630 640 650 660 LTAGQSQVKE RNEDYREITH KLSFPSGRNI FSHDYVFWCG DFNYRIDLTY EEVFYFVKRQ 670 680 690 700 710 720 DWKKLMEFDQ LQLQKSSGKI FKDFHEGAVN FGPTYKYDVG SAAYDTSDKC RTPAWTDRVL 730 740 750 760 770 780 WWRKKHPYDK TAGELNLLDS DLDGDPQIRH TWSPGTLKYY GRAELQASDH RPVLAIVEVE 790 800 810 820 830 840 VQEVDVGARE RVFQEVSSVQ GPLDATVVVN LQSPTLEEKN EFPEDLRTEL MQTLGNYGTI 850 860 870 880 890 900 ILVRINQGQM LVTFADSHSA LSVLDVDGMK VKGRAVKIRP KTKDWLEGLR EELLRKRDSM 910 920 930 940 950 960 APVSPTANSC LLEENFDFSS LDYESEGDVL EEDEDYLVDG FGQPVVSDSE LGGDNSSDTM 970 980 990 1000 1010 1020 SSLTPASKSP ALAKKKQHPT YKDDAHLVTL KQELEVAGNF RHRSPSRSLS VPNRPRPPHP 1030 1040 1050 1060 1070 1080 PQRPPPPTGL MVKKSASDAS ISSGTHGQYS ILQTAKLLPG APQQPPKART GISKPYNVKQ 1090 1100 1110 1120 1130 1140 IKTTNAQEAE AAIRCLLEAS GGVPESAPGA IPLRNQGSSK PEATLGPPAL PRRPAPRVPT 1150 1160 1170 1180 1190 1200 MKKPTLRRTG KVYSGISQCL REELRSAACT PHAVSAQDCG DLNNRWRMPR FSHYIHTKKW 1210 KNVSLSFQDL WLKFRR

References

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[1]	"Molecular cloning of multiple isoforms of synaptojanin 2 and assignment of the gene to mouse chromosome 17A2-3.1." Seet L.-F., Cho S., Hessel A., Dumont D.J. Biochem. Biophys. Res. Commun. 247:116-122(1998) [PubMed: 9636665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5 AND 6), VARIANTS ARG-263; GLY-278 AND PRO-304, ALTERNATIVE SPLICING. Tissue: Brain, Embryo, Endothelial cell and Liver.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Embryonic tail.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: C57BL/6J. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Olfactory epithelium.
[5]	"Developmentally regulated alternative splicing in a novel synaptojanin." Khvotchev M., Suedhof T.C. J. Biol. Chem. 273:2306-2311(1998) [PubMed: 9442075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-1231, FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Strain: C57BL/6J. Tissue: Brain.
[6]	"Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated male mouse sterility but not transmission ratio distortion." Schimenti J.C., Reynolds J.L., Planchart A. Proc. Natl. Acad. Sci. U.S.A. 102:3342-3347(2005) [PubMed: 15722415] [Abstract] Cited for: TISSUE SPECIFICITY, POLYMORPHISM.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF041857 mRNA. Translation: AAC40141.1. AF041858 mRNA. Translation: AAC40142.1. AF041859 mRNA. Translation: AAC40143.1. AF041860 mRNA. Translation: AAC40144.1. AF041861 mRNA. Translation: AAC40145.1. AF041862 mRNA. Translation: AAC40146.1. AK129122 mRNA. Translation: BAC97932.1. Different initiation. AK019694 mRNA. Translation: BAB31837.1. BC058749 mRNA. Translation: AAH58749.1. BC060214 mRNA. Translation: AAH60214.1. AF026123 mRNA. Translation: AAC33137.1. Sequence problems.
IPI	IPI00314785. IPI00399624. IPI00399625. IPI00399626. IPI00403713. IPI00404858.
PIR	JW0105. PW0050. PW0051.
RefSeq	NP_001106822.1. NP_001106823.1. NP_001106824.1. NP_035653.2.
UniGene	Mm.236068
3D structure databases
SMR	Q9D2G5. Positions 513-883, 885-963.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9D2G5.
PTM databases
PhosphoSite	Q9D2G5.
Proteomic databases
PRIDE	Q9D2G5.
Genome annotation databases
Ensembl	ENSMUST00000061091; ENSMUSP00000060382; ENSMUSG00000023805; Mus musculus. [Genome view] ENSMUST00000080283; ENSMUSP00000079164; ENSMUSG00000023805; Mus musculus. [Genome view] ENSMUST00000115791; ENSMUSP00000111457; ENSMUSG00000023805; Mus musculus. [Genome view]
GeneID	20975.
KEGG	mmu:20975.
UCSC	uc008afk.1. mouse. uc008afo.1. mouse. uc008afp.1. mouse. uc008afr.1. mouse. uc008afu.1. mouse.
Organism-specific databases
CTD	20975.
MGI	MGI:1201671. Synj2.
Rouge	Search...
Phylogenomic databases
eggNOG	roNOG05346.
HOVERGEN	Q9D2G5.
InParanoid	Q9D2G5.
OMA	RVLWWRK.
OrthoDB	EOG970X2M.
PhylomeDB	Q9D2G5.
Enzyme and pathway databases
BRENDA	3.1.3.36. 244.
Gene expression databases
ArrayExpress	Q9D2G5.
Bgee	Q9D2G5.
CleanEx	MM_SYNJ2.
Genevestigator	Q9D2G5.
GermOnline	ENSMUSG00000023805. Mus musculus.
Family and domain databases
InterPro	IPR015047. DUF1866. IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. IPR000504. RRM_RNP1. IPR002013. Syja_N. [Graphical view]
Pfam	PF08952. DUF1866. 1 hit. PF03372. Exo_endo_phos. 1 hit. PF02383. Syja_N. 1 hit. [Graphical view]
SMART	SM00128. IPPc. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. PS50275. SAC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	299956.
SOURCE	Search...

Entry information

Entry name

SYNJ2_MOUSE

Accession

Primary (citable) accession number: Q9D2G5
Secondary accession number(s): O35404 , O88399, O88400, O88401, O88402, O88403, O88404

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	January 19, 2010
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)