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Protein

Target of EGR1 protein 1

Gene

Toe1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 323C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Target of EGR1 protein 1
Gene namesi
Name:Toe1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915526. Toe1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002708342 – 511Target of EGR1 protein 1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei349PhosphoserineCombined sources1
Modified residuei429PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D2E2.
PaxDbiQ9D2E2.
PeptideAtlasiQ9D2E2.
PRIDEiQ9D2E2.

PTM databases

iPTMnetiQ9D2E2.
PhosphoSitePlusiQ9D2E2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028688.
CleanExiMM_TOE1.
ExpressionAtlasiQ9D2E2. baseline and differential.
GenevisibleiQ9D2E2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D2E2. 2 interactors.
STRINGi10090.ENSMUSP00000030451.

Structurei

3D structure databases

ProteinModelPortaliQ9D2E2.
SMRiQ9D2E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi336 – 348Nuclear localization signalBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the CAF1 family.Curated
Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 323C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IR2Y. Eukaryota.
ENOG410XNUS. LUCA.
GeneTreeiENSGT00390000004077.
HOGENOMiHOG000231417.
HOVERGENiHBG080270.
InParanoidiQ9D2E2.
KOiK13202.
OMAiGFNFNRQ.
OrthoDBiEOG091G0L18.
PhylomeDBiQ9D2E2.
TreeFamiTF314502.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006941. RNase_CAF1.
IPR012337. RNaseH-like_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04857. CAF1. 2 hits.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D2E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADSDDDVP PVPTPSDGGV NKNTQPAEEF VVRVPVVDVQ SDNFKEIWPS
60 70 80 90 100
LLLALKTASF VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSVLSL
110 120 130 140 150
GLACFRQQPD KGENSYLAQV FNLTLLCIEE YVIEPKSVQF LVQHGFNFNR
160 170 180 190 200
QYAQGIPYHK GNDKGDESQS QSVRTLFLEL IRARRPLVLH NGLIDLVFLY
210 220 230 240 250
QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFV ASYLEYAFRK
260 270 280 290 300
CERENGKQRA AGSPHLALEF CSYPSSMSGH IDYRCCMSPG TCRRSRTTGI
310 320 330 340 350
CDKFSAYGWC PLGPQCPQSH DIDLIIDTDE AVAEDKRRRR RRKDKRKRSL
360 370 380 390 400
QSQPGTQTLA EAEDGPPTKQ VCEDSLETEK MEQKVAEGEA GDQPGSREGH
410 420 430 440 450
TSSLEMAHRR TSAETADVAT SELLVNQAST NPVPGDGLHR AGFDAFMTGY
460 470 480 490 500
VMAYVGLSQG LQLCSSEPWL PECHNKVYLS GKTVPLTVTK SQFSRPSKAH
510
NQKMKLAWGS S
Length:511
Mass (Da):56,871
Last modified:June 1, 2001 - v1
Checksum:iB7E9946A352BED90
GO
Isoform 2 (identifier: Q9D2E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-329: AYGWCPLGPQCPQSHDIDLIIDTD → HTRSRFTGQLWETTIFPVEKLKDI
     330-511: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):37,149
Checksum:i09D4313BD4E6C3FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8D → G in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti15P → S in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti26P → S in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti128I → M in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti182R → W in BAB30482 (PubMed:16141072).Curated1
Sequence conflicti278S → R in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti360A → V in AAH23109 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022242306 – 329AYGWC…IIDTD → HTRSRFTGQLWETTIFPVEK LKDI in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_022243330 – 511Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016889 mRNA. Translation: BAB30482.1.
AK019829 mRNA. Translation: BAB31871.1.
AK046576 mRNA. Translation: BAC32792.1.
AK082975 mRNA. Translation: BAC38718.1.
AK148609 mRNA. Translation: BAE28623.1.
BC023109 mRNA. Translation: AAH23109.1.
CCDSiCCDS18517.1. [Q9D2E2-1]
RefSeqiNP_080930.1. NM_026654.2. [Q9D2E2-1]
UniGeneiMm.30534.

Genome annotation databases

EnsembliENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688. [Q9D2E2-1]
ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688. [Q9D2E2-2]
GeneIDi68276.
KEGGimmu:68276.
UCSCiuc008uhk.1. mouse. [Q9D2E2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016889 mRNA. Translation: BAB30482.1.
AK019829 mRNA. Translation: BAB31871.1.
AK046576 mRNA. Translation: BAC32792.1.
AK082975 mRNA. Translation: BAC38718.1.
AK148609 mRNA. Translation: BAE28623.1.
BC023109 mRNA. Translation: AAH23109.1.
CCDSiCCDS18517.1. [Q9D2E2-1]
RefSeqiNP_080930.1. NM_026654.2. [Q9D2E2-1]
UniGeneiMm.30534.

3D structure databases

ProteinModelPortaliQ9D2E2.
SMRiQ9D2E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D2E2. 2 interactors.
STRINGi10090.ENSMUSP00000030451.

PTM databases

iPTMnetiQ9D2E2.
PhosphoSitePlusiQ9D2E2.

Proteomic databases

EPDiQ9D2E2.
PaxDbiQ9D2E2.
PeptideAtlasiQ9D2E2.
PRIDEiQ9D2E2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688. [Q9D2E2-1]
ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688. [Q9D2E2-2]
GeneIDi68276.
KEGGimmu:68276.
UCSCiuc008uhk.1. mouse. [Q9D2E2-1]

Organism-specific databases

CTDi114034.
MGIiMGI:1915526. Toe1.

Phylogenomic databases

eggNOGiENOG410IR2Y. Eukaryota.
ENOG410XNUS. LUCA.
GeneTreeiENSGT00390000004077.
HOGENOMiHOG000231417.
HOVERGENiHBG080270.
InParanoidiQ9D2E2.
KOiK13202.
OMAiGFNFNRQ.
OrthoDBiEOG091G0L18.
PhylomeDBiQ9D2E2.
TreeFamiTF314502.

Miscellaneous databases

PROiQ9D2E2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028688.
CleanExiMM_TOE1.
ExpressionAtlasiQ9D2E2. baseline and differential.
GenevisibleiQ9D2E2. MM.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006941. RNase_CAF1.
IPR012337. RNaseH-like_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04857. CAF1. 2 hits.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOE1_MOUSE
AccessioniPrimary (citable) accession number: Q9D2E2
Secondary accession number(s): Q3UFD8, Q8R5A4, Q9D412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.