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Protein

Kelch domain-containing protein 8B

Gene

Klhdc8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 8B
Gene namesi
Name:Klhdc8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1925517. Klhdc8b.

Subcellular locationi

  • Cytoplasm

  • Note: In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Kelch domain-containing protein 8BPRO_0000119132Add
BLAST

Proteomic databases

MaxQBiQ9D2D9.
PaxDbiQ9D2D9.
PRIDEiQ9D2D9.

PTM databases

PhosphoSiteiQ9D2D9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032609.
CleanExiMM_KLHDC8B.
ExpressionAtlasiQ9D2D9. baseline and differential.
GenevisibleiQ9D2D9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035232.

Structurei

3D structure databases

ProteinModelPortaliQ9D2D9.
SMRiQ9D2D9. Positions 8-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 3131Kelch 1Add
BLAST
Repeati32 – 7948Kelch 2Add
BLAST
Repeati81 – 12747Kelch 3Add
BLAST
Repeati128 – 17548Kelch 4Add
BLAST
Repeati176 – 22247Kelch 5Add
BLAST
Repeati224 – 28158Kelch 6Add
BLAST
Repeati282 – 32948Kelch 7Add
BLAST
Repeati331 – 35424Kelch 8Add
BLAST

Sequence similaritiesi

Contains 8 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000065733.
HOVERGENiHBG055245.
InParanoidiQ9D2D9.
OMAiNQPCPLA.
OrthoDBiEOG091G08A7.
PhylomeDBiQ9D2D9.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 4 hits.
[Graphical view]
SMARTiSM00612. Kelch. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D2D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGGGRAFA WQVFPPMPTC RVYGTVAHQD GHLLVLGGCG RAGLPLDTAE
60 70 80 90 100
TLDMGSHTWL ALAPLPTARA GAAAVVLGKQ VLVVGGVDEV QSPVAAVEAF
110 120 130 140 150
LADEGRWERR ATLPQAAMGV ATVERDGMVY ALGGMGPDTA PQAQVLVYEP
160 170 180 190 200
RRDCWLSLPS MPTPCYGAST FLHGNKIYVL GGRQGKLPVT AFEAFDLETR
210 220 230 240 250
TWTRHPSLPS RRAFAGCAMA EGSVFSLGGL QQPGPHNFYS RPHFVNTVEM
260 270 280 290 300
FDLEHGSWTK LPRSLRMRDK RADFVVGSLG GNIVAIGGLG NQPCPLASVE
310 320 330 340 350
SFSLARRRWE VLPAMPTARC SCSSLQAGPR LFVIGGVAQG PSQAVEALCL

RDGV
Length:354
Mass (Da):37,592
Last modified:June 1, 2001 - v1
Checksum:iC4C6D88B61A4FDC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019849 mRNA. Translation: BAB31879.1.
AK154428 mRNA. Translation: BAE32579.1.
BC048918 mRNA. Translation: AAH48918.1.
CCDSiCCDS23526.1.
RefSeqiNP_084351.1. NM_030075.2.
XP_006511920.1. XM_006511857.2.
XP_011241219.1. XM_011242917.1.
XP_011241220.1. XM_011242918.1.
XP_011241221.1. XM_011242919.1.
XP_011241222.1. XM_011242920.1.
UniGeneiMm.283194.

Genome annotation databases

EnsembliENSMUST00000035232; ENSMUSP00000035232; ENSMUSG00000032609.
ENSMUST00000193286; ENSMUSP00000142325; ENSMUSG00000032609.
ENSMUST00000193895; ENSMUSP00000141453; ENSMUSG00000032609.
GeneIDi78267.
KEGGimmu:78267.
UCSCiuc009rpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019849 mRNA. Translation: BAB31879.1.
AK154428 mRNA. Translation: BAE32579.1.
BC048918 mRNA. Translation: AAH48918.1.
CCDSiCCDS23526.1.
RefSeqiNP_084351.1. NM_030075.2.
XP_006511920.1. XM_006511857.2.
XP_011241219.1. XM_011242917.1.
XP_011241220.1. XM_011242918.1.
XP_011241221.1. XM_011242919.1.
XP_011241222.1. XM_011242920.1.
UniGeneiMm.283194.

3D structure databases

ProteinModelPortaliQ9D2D9.
SMRiQ9D2D9. Positions 8-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035232.

PTM databases

PhosphoSiteiQ9D2D9.

Proteomic databases

MaxQBiQ9D2D9.
PaxDbiQ9D2D9.
PRIDEiQ9D2D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035232; ENSMUSP00000035232; ENSMUSG00000032609.
ENSMUST00000193286; ENSMUSP00000142325; ENSMUSG00000032609.
ENSMUST00000193895; ENSMUSP00000141453; ENSMUSG00000032609.
GeneIDi78267.
KEGGimmu:78267.
UCSCiuc009rpo.1. mouse.

Organism-specific databases

CTDi200942.
MGIiMGI:1925517. Klhdc8b.

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000065733.
HOVERGENiHBG055245.
InParanoidiQ9D2D9.
OMAiNQPCPLA.
OrthoDBiEOG091G08A7.
PhylomeDBiQ9D2D9.

Miscellaneous databases

PROiQ9D2D9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032609.
CleanExiMM_KLHDC8B.
ExpressionAtlasiQ9D2D9. baseline and differential.
GenevisibleiQ9D2D9. MM.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 4 hits.
[Graphical view]
SMARTiSM00612. Kelch. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLD8B_MOUSE
AccessioniPrimary (citable) accession number: Q9D2D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.