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Protein

snRNA-activating protein complex subunit 3

Gene

Snapc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_240508. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 3
Short name:
SNAPc subunit 3
Alternative name(s):
Small nuclear RNA-activating complex polypeptide 3
Gene namesi
Name:Snapc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1916338. Snapc3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleolus Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407snRNA-activating protein complex subunit 3PRO_0000072026Add
BLAST

Proteomic databases

PRIDEiQ9D2C9.

PTM databases

PhosphoSiteiQ9D2C9.

Expressioni

Gene expression databases

BgeeiQ9D2C9.
ExpressionAtlasiQ9D2C9. baseline and differential.
GenevestigatoriQ9D2C9.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9D2C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAPC3/SRD2 family.Curated

Phylogenomic databases

eggNOGiNOG312262.
GeneTreeiENSGT00390000005708.
HOGENOMiHOG000146435.
HOVERGENiHBG071400.
InParanoidiQ9D2C9.
KOiK15210.
OMAiNIFYPVI.
OrthoDBiEOG73RBB7.
TreeFamiTF317705.

Family and domain databases

InterProiIPR022042. snRNA-activating_su3.
[Graphical view]
PANTHERiPTHR13421. PTHR13421. 1 hit.
PfamiPF12251. zf-SNAP50_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D2C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDLQGGGA GGPQHPVPSA SHSSFPEYEL PELHTRVFHV GSFGELWRGR
60 70 80 90 100
LGAQDLSLSE PQAAEQPTDG GASNDGFEDA AVASDLGCSL EAAAELRVVC
110 120 130 140 150
GLDKLRCLGE DEDPEVIPEN TDLVTLCVRK GLLDYREENI TIDRACRQEI
160 170 180 190 200
FAYEMESHAL GKKPENPADM IEEGECILSV NILYPVIFNK HKEHKPYQTM
210 220 230 240 250
LVLGSQKLTE LRDSICCVSD LQIGGEFSNA PDQAPEHISK DLYKSAFFYF
260 270 280 290 300
EGTFYNDRRY PECRDLSRTI IEWSESHDRG YGKFQTARME DFTFNDLHIK
310 320 330 340 350
LGFPYLYCHQ GDCEHVVVIT DIRLVHHDDC LDRTLYPLLT KKHWLWTRKC
360 370 380 390 400
FVCKMYTARW VTNNDTFAPE DPCFFCDVCF RMLHYDSEGN KLGEFLAYPY

VDPGTFN
Length:407
Mass (Da):46,277
Last modified:March 1, 2003 - v2
Checksum:i8BC79D553C7F5A7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551Y → C in BAC27585 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019863 mRNA. Translation: BAB31890.2.
AK031870 mRNA. Translation: BAC27585.1.
AK049933 mRNA. Translation: BAC33990.1.
BC048713 mRNA. Translation: AAH48713.1.
CCDSiCCDS38792.1.
RefSeqiNP_084225.1. NM_029949.3.
XP_006538432.1. XM_006538369.1.
XP_006538433.1. XM_006538370.1.
XP_006538434.1. XM_006538371.1.
XP_006538435.1. XM_006538372.1.
UniGeneiMm.271985.
Mm.482328.

Genome annotation databases

EnsembliENSMUST00000030206; ENSMUSP00000030206; ENSMUSG00000028483.
ENSMUST00000123262; ENSMUSP00000124038; ENSMUSG00000028483.
ENSMUST00000124856; ENSMUSP00000124181; ENSMUSG00000028483.
ENSMUST00000143533; ENSMUSP00000123793; ENSMUSG00000028483.
GeneIDi77634.
KEGGimmu:77634.
UCSCiuc008tku.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019863 mRNA. Translation: BAB31890.2.
AK031870 mRNA. Translation: BAC27585.1.
AK049933 mRNA. Translation: BAC33990.1.
BC048713 mRNA. Translation: AAH48713.1.
CCDSiCCDS38792.1.
RefSeqiNP_084225.1. NM_029949.3.
XP_006538432.1. XM_006538369.1.
XP_006538433.1. XM_006538370.1.
XP_006538434.1. XM_006538371.1.
XP_006538435.1. XM_006538372.1.
UniGeneiMm.271985.
Mm.482328.

3D structure databases

ProteinModelPortaliQ9D2C9.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9D2C9.

Proteomic databases

PRIDEiQ9D2C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030206; ENSMUSP00000030206; ENSMUSG00000028483.
ENSMUST00000123262; ENSMUSP00000124038; ENSMUSG00000028483.
ENSMUST00000124856; ENSMUSP00000124181; ENSMUSG00000028483.
ENSMUST00000143533; ENSMUSP00000123793; ENSMUSG00000028483.
GeneIDi77634.
KEGGimmu:77634.
UCSCiuc008tku.1. mouse.

Organism-specific databases

CTDi6619.
MGIiMGI:1916338. Snapc3.

Phylogenomic databases

eggNOGiNOG312262.
GeneTreeiENSGT00390000005708.
HOGENOMiHOG000146435.
HOVERGENiHBG071400.
InParanoidiQ9D2C9.
KOiK15210.
OMAiNIFYPVI.
OrthoDBiEOG73RBB7.
TreeFamiTF317705.

Enzyme and pathway databases

ReactomeiREACT_240508. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Miscellaneous databases

ChiTaRSiSnapc3. mouse.
NextBioi347276.
PROiQ9D2C9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D2C9.
ExpressionAtlasiQ9D2C9. baseline and differential.
GenevestigatoriQ9D2C9.

Family and domain databases

InterProiIPR022042. snRNA-activating_su3.
[Graphical view]
PANTHERiPTHR13421. PTHR13421. 1 hit.
PfamiPF12251. zf-SNAP50_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus, Medulla oblongata, Ovary and Uterus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSNPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9D2C9
Secondary accession number(s): Q8C0A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.