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Protein

Bax inhibitor 1

Gene

Tmbim6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling (By similarity). Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (PubMed:21926971).By similarity1 Publication

GO - Molecular functioni

  • endoribonuclease inhibitor activity Source: ParkinsonsUK-UCL
  • enzyme binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy, Unfolded protein response

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Bax inhibitor 1
Short name:
BI-1
Alternative name(s):
Testis-enhanced gene transcript protein
Transmembrane BAX inhibitor motif-containing protein 6
Gene namesi
Name:Tmbim6
Synonyms:Tegt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:99682. Tmbim6.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Topological domaini51 – 522LumenalSequence analysis
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Topological domaini74 – 8613CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 1125LumenalSequence analysis
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 1396CytoplasmicSequence analysis
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Topological domaini161 – 1666LumenalSequence analysis
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 20619CytoplasmicSequence analysisAdd
BLAST
Intramembranei207 – 22721HelicalSequence analysisAdd
BLAST
Topological domaini228 – 23710CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Bax inhibitor 1PRO_0000179079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki7 – 7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9D2C7.
PaxDbiQ9D2C7.
PRIDEiQ9D2C7.

PTM databases

iPTMnetiQ9D2C7.
PhosphoSiteiQ9D2C7.

Expressioni

Tissue specificityi

Highly abundant in adult testis.1 Publication

Gene expression databases

BgeeiQ9D2C7.
ExpressionAtlasiQ9D2C7. baseline and differential.
GenevisibleiQ9D2C7. MM.

Interactioni

Subunit structurei

Interacts with BCL2 (By similarity). Interacts with BCL2L1 (PubMed:21926971).By similarity1 Publication

GO - Molecular functioni

  • enzyme binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

IntActiQ9D2C7. 1 interaction.
MINTiMINT-1858673.
STRINGi10090.ENSMUSP00000023749.

Structurei

3D structure databases

ProteinModelPortaliQ9D2C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.By similarity

Sequence similaritiesi

Belongs to the BI1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1629. Eukaryota.
ENOG4111GCT. LUCA.
GeneTreeiENSGT00390000006722.
HOGENOMiHOG000238748.
HOVERGENiHBG001192.
InParanoidiQ9D2C7.
OMAiWLAMTPH.
OrthoDBiEOG7KH9KT.
PhylomeDBiQ9D2C7.
TreeFamiTF323395.

Family and domain databases

InterProiIPR006213. Bax_inhbtr1_CS.
IPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PROSITEiPS01243. BI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D2C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHVV
60 70 80 90 100
THFIQAGLLS ALGSLALMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG
110 120 130 140 150
PALELCIAVN PSILPTAFMG TAMIFTCFSL SALYARRRSY LFLGGILMSA
160 170 180 190 200
MSLMLLSSLG NLFFGSIWLF QANLYLGLLV MCGFVLFDTQ LIIEKAEHGD
210 220 230
KDYIWHCVDL FLDFVTLFRK LMLILAFNEK DKKKEKK
Length:237
Mass (Da):26,478
Last modified:June 1, 2001 - v1
Checksum:i788E6EE7EB34AFFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931F → Y in BAC29575 (PubMed:16141072).Curated
Sequence conflicti93 – 931F → Y in BAC29662 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019865 mRNA. Translation: BAB31892.1.
AK036782 mRNA. Translation: BAC29575.1.
AK036994 mRNA. Translation: BAC29662.1.
AK049604 mRNA. Translation: BAC33837.1.
AK050299 mRNA. Translation: BAC34174.1.
AK050323 mRNA. Translation: BAC34188.1.
AK088030 mRNA. Translation: BAC40107.1.
AK088683 mRNA. Translation: BAC40503.1.
AK139901 mRNA. Translation: BAE24176.1.
AK159380 mRNA. Translation: BAE35035.1.
AK166935 mRNA. Translation: BAE39128.1.
BC005588 mRNA. Translation: AAH05588.1.
CCDSiCCDS37201.1.
RefSeqiNP_001164505.1. NM_001171034.1.
NP_001164506.1. NM_001171035.1.
NP_001164507.1. NM_001171036.1.
NP_080945.1. NM_026669.4.
UniGeneiMm.16769.

Genome annotation databases

EnsembliENSMUST00000023749; ENSMUSP00000023749; ENSMUSG00000023010.
ENSMUST00000159209; ENSMUSP00000125117; ENSMUSG00000023010.
ENSMUST00000159531; ENSMUSP00000125318; ENSMUSG00000023010.
ENSMUST00000160635; ENSMUSP00000124651; ENSMUSG00000023010.
ENSMUST00000161250; ENSMUSP00000125563; ENSMUSG00000023010.
GeneIDi110213.
KEGGimmu:110213.
UCSCiuc007xpm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019865 mRNA. Translation: BAB31892.1.
AK036782 mRNA. Translation: BAC29575.1.
AK036994 mRNA. Translation: BAC29662.1.
AK049604 mRNA. Translation: BAC33837.1.
AK050299 mRNA. Translation: BAC34174.1.
AK050323 mRNA. Translation: BAC34188.1.
AK088030 mRNA. Translation: BAC40107.1.
AK088683 mRNA. Translation: BAC40503.1.
AK139901 mRNA. Translation: BAE24176.1.
AK159380 mRNA. Translation: BAE35035.1.
AK166935 mRNA. Translation: BAE39128.1.
BC005588 mRNA. Translation: AAH05588.1.
CCDSiCCDS37201.1.
RefSeqiNP_001164505.1. NM_001171034.1.
NP_001164506.1. NM_001171035.1.
NP_001164507.1. NM_001171036.1.
NP_080945.1. NM_026669.4.
UniGeneiMm.16769.

3D structure databases

ProteinModelPortaliQ9D2C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D2C7. 1 interaction.
MINTiMINT-1858673.
STRINGi10090.ENSMUSP00000023749.

PTM databases

iPTMnetiQ9D2C7.
PhosphoSiteiQ9D2C7.

Proteomic databases

MaxQBiQ9D2C7.
PaxDbiQ9D2C7.
PRIDEiQ9D2C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023749; ENSMUSP00000023749; ENSMUSG00000023010.
ENSMUST00000159209; ENSMUSP00000125117; ENSMUSG00000023010.
ENSMUST00000159531; ENSMUSP00000125318; ENSMUSG00000023010.
ENSMUST00000160635; ENSMUSP00000124651; ENSMUSG00000023010.
ENSMUST00000161250; ENSMUSP00000125563; ENSMUSG00000023010.
GeneIDi110213.
KEGGimmu:110213.
UCSCiuc007xpm.2. mouse.

Organism-specific databases

CTDi7009.
MGIiMGI:99682. Tmbim6.

Phylogenomic databases

eggNOGiKOG1629. Eukaryota.
ENOG4111GCT. LUCA.
GeneTreeiENSGT00390000006722.
HOGENOMiHOG000238748.
HOVERGENiHBG001192.
InParanoidiQ9D2C7.
OMAiWLAMTPH.
OrthoDBiEOG7KH9KT.
PhylomeDBiQ9D2C7.
TreeFamiTF323395.

Miscellaneous databases

ChiTaRSiTmbim6. mouse.
NextBioi363547.
PROiQ9D2C7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D2C7.
ExpressionAtlasiQ9D2C7. baseline and differential.
GenevisibleiQ9D2C7. MM.

Family and domain databases

InterProiIPR006213. Bax_inhbtr1_CS.
IPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PROSITEiPS01243. BI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Egg, Liver, Ovary, Spinal cord, Thymus and Uterus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "A novel, conserved gene of the rat that is developmentally regulated in the testis."
    Walter L., Dirks B., Rothermel E., Heyens M., Szpirer C., Levan G., Guenther E.
    Mamm. Genome 5:216-221(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "BAX inhibitor-1 regulates autophagy by controlling the IRE1alpha branch of the unfolded protein response."
    Castillo K., Rojas-Rivera D., Lisbona F., Caballero B., Nassif M., Court F.A., Schuck S., Ibar C., Walter P., Sierralta J., Glavic A., Hetz C.
    EMBO J. 30:4465-4478(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BCL2L1.

Entry informationi

Entry nameiBI1_MOUSE
AccessioniPrimary (citable) accession number: Q9D2C7
Secondary accession number(s): Q3TX81, Q8BFY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.