Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA-splicing factor SPF27

Gene

Bcas2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SPF27
Alternative name(s):
Breast carcinoma-amplified sequence 2 homolog
DNA amplified in mammary carcinoma 1 protein
Gene namesi
Name:Bcas2
Synonyms:Dam1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915433 Bcas2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000648622 – 225Pre-mRNA-splicing factor SPF27Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei94PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D287
MaxQBiQ9D287
PaxDbiQ9D287
PeptideAtlasiQ9D287
PRIDEiQ9D287

PTM databases

PhosphoSitePlusiQ9D287

Expressioni

Gene expression databases

BgeeiENSMUSG00000005687
CleanExiMM_BCAS2
ExpressionAtlasiQ9D287 baseline and differential
GenevisibleiQ9D287 MM

Interactioni

Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly in the complex with PRPF19, CDC5L and PLRG1.By similarity

Protein-protein interaction databases

BioGridi212708, 34 interactors
IntActiQ9D287, 35 interactors
MINTiQ9D287
STRINGi10090.ENSMUSP00000005830

Structurei

3D structure databases

ProteinModelPortaliQ9D287
SMRiQ9D287
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 222Sequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 34Poly-Ala4

Sequence similaritiesi

Belongs to the SPF27 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3096 Eukaryota
ENOG41101IB LUCA
GeneTreeiENSGT00390000014494
HOGENOMiHOG000007540
HOVERGENiHBG050675
InParanoidiQ9D287
KOiK12861
OMAiLPYIDHG
OrthoDBiEOG091G0NMJ
PhylomeDBiQ9D287
TreeFamiTF105818

Family and domain databases

InterProiView protein in InterPro
IPR008409 SPF27
PANTHERiPTHR13296 PTHR13296, 1 hit
PfamiView protein in Pfam
PF05700 BCAS2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTGLVAGE VVVDALPYFD QGYEAPGVRE AAAALVEEET RRYRPTKNYL
60 70 80 90 100
SYLTAPDYSA FETDIMRNEF ERLAARQPIE LLSMKRYELP APSSGQKNDI
110 120 130 140 150
TAWQECVNNS MAQLEHQAVR IENLELMSQH GCNAWKVYNE NLVHMIEHAQ
160 170 180 190 200
KELQKLRKHI QDLNWQRKNM QLTAGSKLRE MESNWVSLVS KNYEIERTIV
210 220
QLENEIYQIK QQHGEANKEN IRQDF
Length:225
Mass (Da):26,131
Last modified:June 1, 2001 - v1
Checksum:i9112718EEFD96890
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28V → A in BAB24258 (PubMed:16141072).Curated1
Sequence conflicti106C → W in BAB24258 (PubMed:16141072).Curated1
Sequence conflicti137V → G in BAB31409 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043239 mRNA Translation: AAK85306.1
AK005825 mRNA Translation: BAB24258.1
AK018786 mRNA Translation: BAB31409.1
AK020098 mRNA Translation: BAB31992.1
AK166967 mRNA Translation: BAE39150.1
BC037062 mRNA Translation: AAH37062.1
CCDSiCCDS17691.1
RefSeqiNP_080878.2, NM_026602.3
UniGeneiMm.104919

Genome annotation databases

EnsembliENSMUST00000005830; ENSMUSP00000005830; ENSMUSG00000005687
GeneIDi68183
KEGGimmu:68183
UCSCiuc008qsu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSPF27_MOUSE
AccessioniPrimary (citable) accession number: Q9D287
Secondary accession number(s): Q3TKJ5
, Q91YX8, Q9D2U4, Q9DAI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health