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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

Batf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens.3 Publications

Miscellaneous

The increased protection toward L.monocytogenes infection in mice lacking Batf3 suggests that CD8-alpha+ classical dendritic cells (cDCs) and CD103+ dendritic cells are an entry point for infection by L.monocytogenes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • dendritic cell differentiation Source: UniProtKB
  • myeloid dendritic cell differentiation Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • response to virus Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Gene namesi
Name:Batf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1925491 Batf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Selective loss of CD8-alpha+ classical dendritic cells (cDCs) and CD103+ dendritic cells, without abnormalities in other hematopoietic cell types or architecture. Dendritic cells are defective in cross-presentation, and mice lack virus-specific CD8+ T-cell responses to West Nile virus. Mice also show reduced priming of CD8 T-cells after pulmonary Sendai virus infection, with increased pulmonary inflammation. Mice are extremely susceptible to T.gondii infection, with decreased production of interleukin-12 (IL12) and interferon-gamma. In contrast, mice are more resistant to L.monocytogenes infection.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261071 – 118Basic leucine zipper transcriptional factor ATF-like 3Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D275
MaxQBiQ9D275
PaxDbiQ9D275
PRIDEiQ9D275

PTM databases

PhosphoSitePlusiQ9D275

Expressioni

Tissue specificityi

Highly expressed in CD8-alpha+ classical dendritic cells (cDCs), with low to absent expression in other immune cells and non-immune tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026630
GenevisibleiQ9D275 MM

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

Protein-protein interaction databases

BioGridi237877, 13 interactors
IntActiQ9D275, 11 interactors
STRINGi10090.ENSMUSP00000027943

Structurei

3D structure databases

ProteinModelPortaliQ9D275
SMRiQ9D275
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 91bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 55Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni56 – 84Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000016869
HOGENOMiHOG000236325
HOVERGENiHBG096186
InParanoidiQ9D275
KOiK09034
OMAiLTDEMKH
OrthoDBiEOG091G0YSM
PhylomeDBiQ9D275
TreeFamiTF332340

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029818 p21SNFT
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF13 PTHR23351:SF13, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGPPAVSV LQRSVDAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT
60 70 80 90 100
QKADKLHEEH ESLEQENSVL RREISKLKEE LRHLSEVLKE HEKMCPLLLC
110
PMNFVQLRSD PVASCLPR
Length:118
Mass (Da):13,657
Last modified:June 1, 2001 - v1
Checksum:i67EA973561ECCFA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020278 mRNA Translation: BAB32053.1
BC117083 mRNA Translation: AAI17084.1
BC117085 mRNA Translation: AAI17086.1
CCDSiCCDS15615.1
RefSeqiNP_084336.1, NM_030060.2
UniGeneiMm.6922

Genome annotation databases

EnsembliENSMUST00000027943; ENSMUSP00000027943; ENSMUSG00000026630
GeneIDi381319
KEGGimmu:381319
UCSCiuc007ecd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBATF3_MOUSE
AccessioniPrimary (citable) accession number: Q9D275
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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