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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

Batf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens.3 Publications

GO - Molecular functioni

GO - Biological processi

  • dendritic cell differentiation Source: UniProtKB
  • myeloid dendritic cell differentiation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to virus Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Gene namesi
Name:Batf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1925491. Batf3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Selective loss of CD8-alpha+ classical dendritic cells (cDCs) and CD103+ dendritic cells, without abnormalities in other hematopoietic cell types or architecture. Dendritic cells are defective in cross-presentation, and mice lack virus-specific CD8+ T-cell responses to West Nile virus. Mice also show reduced priming of CD8 T-cells after pulmonary Sendai virus infection, with increased pulmonary inflammation. Mice are extremely susceptible to T.gondii infection, with decreased production of interleukin-12 (IL12) and interferon-gamma. In contrast, mice are more resistant to L.monocytogenes infection.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118Basic leucine zipper transcriptional factor ATF-like 3PRO_0000326107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D275.
PaxDbiQ9D275.
PRIDEiQ9D275.

PTM databases

PhosphoSiteiQ9D275.

Expressioni

Tissue specificityi

Highly expressed in CD8-alpha+ classical dendritic cells (cDCs), with low to absent expression in other immune cells and non-immune tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026630.
GenevisibleiQ9D275. MM.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

Protein-protein interaction databases

BioGridi237877. 13 interactions.
IntActiQ9D275. 11 interactions.
STRINGi10090.ENSMUSP00000027943.

Structurei

3D structure databases

ProteinModelPortaliQ9D275.
SMRiQ9D275. Positions 33-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 9164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 5526Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni56 – 8429Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiQ9D275.
KOiK09034.
OMAiCPLLHCT.
OrthoDBiEOG091G0YSM.
PhylomeDBiQ9D275.
TreeFamiTF332340.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF13. PTHR23351:SF13. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGPPAVSV LQRSVDAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT
60 70 80 90 100
QKADKLHEEH ESLEQENSVL RREISKLKEE LRHLSEVLKE HEKMCPLLLC
110
PMNFVQLRSD PVASCLPR
Length:118
Mass (Da):13,657
Last modified:June 1, 2001 - v1
Checksum:i67EA973561ECCFA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020278 mRNA. Translation: BAB32053.1.
BC117083 mRNA. Translation: AAI17084.1.
BC117085 mRNA. Translation: AAI17086.1.
CCDSiCCDS15615.1.
RefSeqiNP_084336.1. NM_030060.2.
UniGeneiMm.6922.

Genome annotation databases

EnsembliENSMUST00000027943; ENSMUSP00000027943; ENSMUSG00000026630.
GeneIDi381319.
KEGGimmu:381319.
UCSCiuc007ecd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020278 mRNA. Translation: BAB32053.1.
BC117083 mRNA. Translation: AAI17084.1.
BC117085 mRNA. Translation: AAI17086.1.
CCDSiCCDS15615.1.
RefSeqiNP_084336.1. NM_030060.2.
UniGeneiMm.6922.

3D structure databases

ProteinModelPortaliQ9D275.
SMRiQ9D275. Positions 33-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237877. 13 interactions.
IntActiQ9D275. 11 interactions.
STRINGi10090.ENSMUSP00000027943.

PTM databases

PhosphoSiteiQ9D275.

Proteomic databases

EPDiQ9D275.
PaxDbiQ9D275.
PRIDEiQ9D275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027943; ENSMUSP00000027943; ENSMUSG00000026630.
GeneIDi381319.
KEGGimmu:381319.
UCSCiuc007ecd.1. mouse.

Organism-specific databases

CTDi55509.
MGIiMGI:1925491. Batf3.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiQ9D275.
KOiK09034.
OMAiCPLLHCT.
OrthoDBiEOG091G0YSM.
PhylomeDBiQ9D275.
TreeFamiTF332340.

Miscellaneous databases

PROiQ9D275.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026630.
GenevisibleiQ9D275. MM.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF13. PTHR23351:SF13. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBATF3_MOUSE
AccessioniPrimary (citable) accession number: Q9D275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The increased protection toward L.monocytogenes infection in mice lacking Batf3 suggests that CD8-alpha+ classical dendritic cells (cDCs) and CD103+ dendritic cells are an entry point for infection by L.monocytogenes.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.