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Q9D273

- MMAB_MOUSE

UniProt

Q9D273 - MMAB_MOUSE

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial

Gene

Mmab

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
    ATP + cobinamide = triphosphate + adenosylcobinamide.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPBy similarity
    Binding sitei208 – 2081ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 574ATPBy similarity
    Nucleotide bindingi62 – 632ATPBy similarity
    Nucleotide bindingi184 – 1885ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.
    UniPathwayiUPA00148; UER00233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (EC:2.5.1.17)
    Alternative name(s):
    Cob(I)alamin adenosyltransferase
    Methylmalonic aciduria type B homolog
    Gene namesi
    Name:Mmab
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1924947. Mmab.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
    BLAST
    Chaini27 – 237211Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialPRO_0000005569Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei205 – 2051N6-succinyllysine1 Publication
    Modified residuei224 – 2241N6-acetyllysine; alternate1 Publication
    Modified residuei224 – 2241N6-succinyllysine; alternate1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9D273.
    PaxDbiQ9D273.
    PRIDEiQ9D273.

    PTM databases

    PhosphoSiteiQ9D273.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D273.
    BgeeiQ9D273.
    GenevestigatoriQ9D273.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000098418.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D273.
    SMRiQ9D273. Positions 52-234.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2096.
    GeneTreeiENSGT00390000008432.
    HOGENOMiHOG000291639.
    HOVERGENiHBG045589.
    KOiK00798.
    OMAiFVAARHA.
    OrthoDBiEOG7X3QS4.
    PhylomeDBiQ9D273.
    TreeFamiTF312942.

    Family and domain databases

    Gene3Di1.20.1200.10. 1 hit.
    InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view]
    PfamiPF01923. Cob_adeno_trans. 1 hit.
    [Graphical view]
    ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF89028. SSF89028. 1 hit.
    TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D273-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVWLFGGRL GLRGRLSACR LLCPRFQSRG PQGGEDGDRL QPSSTAAKIP    50
    KIYTKTGDKG FSSTFTGERR PKDDQVFEAV GTTDELSSAI GFAMELVTEK 100
    GHMFAEELQK IQCMLQDVGS ALATPRSSAR EAHLKHTAFQ EGPVLELERW 150
    IDKYSSQLPP LKAFILPSGG KSSSALHFCR AVCRRAERRV VPLVQMGETD 200
    ANVAKFLNRL SDYLFTVARY AAMKEGSQEK IYKKHDV 237
    Length:237
    Mass (Da):26,273
    Last modified:June 1, 2001 - v1
    Checksum:iCB0408BC575FE8CB
    GO
    Isoform 2 (identifier: Q9D273-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-237: LSDYLFTVARYAAMKEGSQEKIYKKHDV → CLSGVWRVCL...LGNKSQRRHT

    Note: Due to intron retention. No experimental confirmation available.

    Show »
    Length:257
    Mass (Da):28,233
    Checksum:i32F55E6662F598C4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei210 – 23728LSDYL…KKHDV → CLSGVWRVCLTTRPLPSSCI LDCAVSPVALSHSEVRLCLG NKSQRRHT in isoform 2. 1 PublicationVSP_008847Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020286 mRNA. Translation: BAB32055.1.
    AK034288 mRNA. Translation: BAC28659.1.
    AK088785 mRNA. Translation: BAC40571.1.
    AK148421 mRNA. Translation: BAE28544.1.
    BC022159 mRNA. Translation: AAH22159.1.
    BC057558 mRNA. Translation: AAH57558.1.
    CCDSiCCDS19565.1. [Q9D273-1]
    RefSeqiNP_084232.1. NM_029956.3. [Q9D273-1]
    XP_006530568.1. XM_006530505.1. [Q9D273-2]
    UniGeneiMm.105182.

    Genome annotation databases

    EnsembliENSMUST00000031560; ENSMUSP00000031560; ENSMUSG00000029575. [Q9D273-1]
    GeneIDi77697.
    KEGGimmu:77697.
    UCSCiuc008yzo.1. mouse. [Q9D273-1]
    uc008yzp.1. mouse. [Q9D273-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020286 mRNA. Translation: BAB32055.1 .
    AK034288 mRNA. Translation: BAC28659.1 .
    AK088785 mRNA. Translation: BAC40571.1 .
    AK148421 mRNA. Translation: BAE28544.1 .
    BC022159 mRNA. Translation: AAH22159.1 .
    BC057558 mRNA. Translation: AAH57558.1 .
    CCDSi CCDS19565.1. [Q9D273-1 ]
    RefSeqi NP_084232.1. NM_029956.3. [Q9D273-1 ]
    XP_006530568.1. XM_006530505.1. [Q9D273-2 ]
    UniGenei Mm.105182.

    3D structure databases

    ProteinModelPortali Q9D273.
    SMRi Q9D273. Positions 52-234.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000098418.

    PTM databases

    PhosphoSitei Q9D273.

    Proteomic databases

    MaxQBi Q9D273.
    PaxDbi Q9D273.
    PRIDEi Q9D273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031560 ; ENSMUSP00000031560 ; ENSMUSG00000029575 . [Q9D273-1 ]
    GeneIDi 77697.
    KEGGi mmu:77697.
    UCSCi uc008yzo.1. mouse. [Q9D273-1 ]
    uc008yzp.1. mouse. [Q9D273-2 ]

    Organism-specific databases

    CTDi 326625.
    MGIi MGI:1924947. Mmab.

    Phylogenomic databases

    eggNOGi COG2096.
    GeneTreei ENSGT00390000008432.
    HOGENOMi HOG000291639.
    HOVERGENi HBG045589.
    KOi K00798.
    OMAi FVAARHA.
    OrthoDBi EOG7X3QS4.
    PhylomeDBi Q9D273.
    TreeFami TF312942.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00233 .
    Reactomei REACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.

    Miscellaneous databases

    NextBioi 347375.
    PROi Q9D273.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D273.
    Bgeei Q9D273.
    Genevestigatori Q9D273.

    Family and domain databases

    Gene3Di 1.20.1200.10. 1 hit.
    InterProi IPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view ]
    Pfami PF01923. Cob_adeno_trans. 1 hit.
    [Graphical view ]
    ProDomi PD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF89028. SSF89028. 1 hit.
    TIGRFAMsi TIGR00636. PduO_Nterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Cecum, Diencephalon and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain and Liver.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-205 AND LYS-224, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-224, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiMMAB_MOUSE
    AccessioniPrimary (citable) accession number: Q9D273
    Secondary accession number(s): Q3UFL6, Q8CBZ0, Q8VBZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3