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Q9D270 (ZDH21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable palmitoyltransferase ZDHHC21
EC=2.3.1.-
Alternative name(s):
GABA-A receptor-associated membrane protein 3
Zinc finger DHHC domain-containing protein 21
Short name=DHHC-21
Gene names
Name:Zdhhc21
Synonyms:Gramp3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor By similarity.

Catalytic activity

Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.

Subcellular location

Membrane; Multi-pass membrane protein Potential. Golgi apparatus By similarity.

Domain

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family.

Contains 1 DHHC-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Probable palmitoyltransferase ZDHHC21
PRO_0000212909

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane186 – 20621Helical; Potential
Zinc finger90 – 14051DHHC-type

Experimental info

Sequence conflict671A → T in AAO27361. Ref.1
Sequence conflict671A → T in BAB32059. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9D270 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: BA3F428AAE4637DB

FASTA26531,331
        10         20         30         40         50         60 
MGLRIHFVVD PHGWCCMGLI VFVWLYNIVI IPKIVLFPHY EEGHIPGILI IIFYGISIFC 

        70         80         90        100        110        120 
LVALVRASLT DPGRLPENPK IPHAERELWE LCNKCNLMRP KRSHHCSRCG HCVRRMDHHC 

       130        140        150        160        170        180 
PWINNCVGED NHWLFLQLCF YTELLTCYAL MFSFCHYYYF LPLKKRNLDL FVVRHELAIM 

       190        200        210        220        230        240 
RLAAFMGITM LVGITGLFYT QLIGIITDTT SIEKMSNCCE EISRPRKPWQ QTFSEVFGTR 

       250        260 
WKILWFIPFR QRQPLRVPYH FANHV

« Hide

References

« Hide 'large scale' references
[1]"The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ."
Keller C.A., Yuan X., Panzanelli P., Martin M.L., Alldred M., Sassoe-Pognetto M., Luescher B.
J. Neurosci. 24:5881-5891(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Cecum.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cecum.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY166674 mRNA. Translation: AAO27361.1.
AK020293 mRNA. Translation: BAB32059.1.
AL671005 Genomic DNA. Translation: CAI26022.1.
BC043110 mRNA. Translation: AAH43110.1.
IPIIPI00330766.
RefSeqNP_080923.2. NM_026647.3.
UniGeneMm.32047.

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ9D270.

Proteomic databases

PaxDbQ9D270.
PRIDEQ9D270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030110; ENSMUSP00000030110; ENSMUSG00000028403.
ENSMUST00000107239; ENSMUSP00000102859; ENSMUSG00000028403.
GeneID68268.
KEGGmmu:68268.
UCSCuc008tkj.2. mouse.

Organism-specific databases

CTD340481.
MGIMGI:1915518. Zdhhc21.

Phylogenomic databases

eggNOGCOG5273.
GeneTreeENSGT00670000097875.
HOGENOMHOG000013210.
HOVERGENHBG055594.
InParanoidQ9D270.
OMASGLFYTQ.
OrthoDBEOG40P47C.

Gene expression databases

ArrayExpressQ9D270.
BgeeQ9D270.
CleanExMM_ZDHHC21.
GenevestigatorQ9D270.
GermOnlineENSMUSG00000028403. Mus musculus.

Family and domain databases

InterProIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio326866.
SOURCESearch...

Entry information

Entry nameZDH21_MOUSE
AccessionPrimary (citable) accession number: Q9D270
Secondary accession number(s): Q6EMK1, Q80XQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 22, 2005
Last modified: April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents