Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable palmitoyltransferase ZDHHC21

Gene

Zdhhc21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • hair follicle development Source: MGI
  • peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  • protein palmitoylation Source: MGI
  • sebaceous gland development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-203615. eNOS activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC21 (EC:2.3.1.225)
Alternative name(s):
GABA-A receptor-associated membrane protein 3
Zinc finger DHHC domain-containing protein 21
Short name:
DHHC-21
Gene namesi
Name:Zdhhc21
Synonyms:Gramp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915518. Zdhhc21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Probable palmitoyltransferase ZDHHC21PRO_0000212909Add
BLAST

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9D270.
PaxDbiQ9D270.
PeptideAtlasiQ9D270.
PRIDEiQ9D270.

PTM databases

PhosphoSiteiQ9D270.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028403.
CleanExiMM_ZDHHC21.
ExpressionAtlasiQ9D270. baseline and differential.
GenevisibleiQ9D270. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030110.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 14051DHHCPROSITE-ProRule annotationAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000013210.
HOVERGENiHBG055594.
InParanoidiQ9D270.
KOiK18932.
OMAiYFIFVES.
OrthoDBiEOG091G0DM3.
PhylomeDBiQ9D270.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRIHFVVD PHGWCCMGLI VFVWLYNIVI IPKIVLFPHY EEGHIPGILI
60 70 80 90 100
IIFYGISIFC LVALVRASLT DPGRLPENPK IPHAERELWE LCNKCNLMRP
110 120 130 140 150
KRSHHCSRCG HCVRRMDHHC PWINNCVGED NHWLFLQLCF YTELLTCYAL
160 170 180 190 200
MFSFCHYYYF LPLKKRNLDL FVVRHELAIM RLAAFMGITM LVGITGLFYT
210 220 230 240 250
QLIGIITDTT SIEKMSNCCE EISRPRKPWQ QTFSEVFGTR WKILWFIPFR
260
QRQPLRVPYH FANHV
Length:265
Mass (Da):31,331
Last modified:November 22, 2005 - v2
Checksum:iBA3F428AAE4637DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671A → T in AAO27361 (PubMed:15229235).Curated
Sequence conflicti67 – 671A → T in BAB32059 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY166674 mRNA. Translation: AAO27361.1.
AK020293 mRNA. Translation: BAB32059.1.
AL671005 Genomic DNA. Translation: CAI26022.1.
BC043110 mRNA. Translation: AAH43110.1.
CCDSiCCDS18294.1.
RefSeqiNP_080923.2. NM_026647.3.
XP_006538279.1. XM_006538216.2.
XP_011248395.1. XM_011250093.1.
XP_011248396.1. XM_011250094.1.
XP_011248397.1. XM_011250095.1.
XP_011248398.1. XM_011250096.1.
UniGeneiMm.32047.

Genome annotation databases

EnsembliENSMUST00000030110; ENSMUSP00000030110; ENSMUSG00000028403.
ENSMUST00000107239; ENSMUSP00000102859; ENSMUSG00000028403.
GeneIDi68268.
KEGGimmu:68268.
UCSCiuc008tkj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY166674 mRNA. Translation: AAO27361.1.
AK020293 mRNA. Translation: BAB32059.1.
AL671005 Genomic DNA. Translation: CAI26022.1.
BC043110 mRNA. Translation: AAH43110.1.
CCDSiCCDS18294.1.
RefSeqiNP_080923.2. NM_026647.3.
XP_006538279.1. XM_006538216.2.
XP_011248395.1. XM_011250093.1.
XP_011248396.1. XM_011250094.1.
XP_011248397.1. XM_011250095.1.
XP_011248398.1. XM_011250096.1.
UniGeneiMm.32047.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030110.

PTM databases

PhosphoSiteiQ9D270.

Proteomic databases

MaxQBiQ9D270.
PaxDbiQ9D270.
PeptideAtlasiQ9D270.
PRIDEiQ9D270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030110; ENSMUSP00000030110; ENSMUSG00000028403.
ENSMUST00000107239; ENSMUSP00000102859; ENSMUSG00000028403.
GeneIDi68268.
KEGGimmu:68268.
UCSCiuc008tkj.2. mouse.

Organism-specific databases

CTDi340481.
MGIiMGI:1915518. Zdhhc21.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000013210.
HOVERGENiHBG055594.
InParanoidiQ9D270.
KOiK18932.
OMAiYFIFVES.
OrthoDBiEOG091G0DM3.
PhylomeDBiQ9D270.
TreeFamiTF319798.

Enzyme and pathway databases

ReactomeiR-MMU-203615. eNOS activation.

Miscellaneous databases

PROiQ9D270.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028403.
CleanExiMM_ZDHHC21.
ExpressionAtlasiQ9D270. baseline and differential.
GenevisibleiQ9D270. MM.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH21_MOUSE
AccessioniPrimary (citable) accession number: Q9D270
Secondary accession number(s): Q6EMK1, Q80XQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.