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Protein

Probable palmitoyltransferase ZDHHC21

Gene

Zdhhc21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • hair follicle development Source: MGI
  • peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  • protein palmitoylation Source: MGI
  • sebaceous gland development Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-203615 eNOS activation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC21 (EC:2.3.1.225)
Alternative name(s):
GABA-A receptor-associated membrane protein 3
Zinc finger DHHC domain-containing protein 21
Short name:
DHHC-21
Gene namesi
Name:Zdhhc21
Synonyms:Gramp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915518 Zdhhc21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129091 – 265Probable palmitoyltransferase ZDHHC21Add BLAST265

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9D270
PaxDbiQ9D270
PeptideAtlasiQ9D270
PRIDEiQ9D270

PTM databases

PhosphoSitePlusiQ9D270

Expressioni

Gene expression databases

BgeeiENSMUSG00000028403
CleanExiMM_ZDHHC21
ExpressionAtlasiQ9D270 baseline and differential
GenevisibleiQ9D270 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030110

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 140DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000013210
HOVERGENiHBG055594
InParanoidiQ9D270
KOiK18932
OMAiCNMMRPK
OrthoDBiEOG091G0DM3
PhylomeDBiQ9D270
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRIHFVVD PHGWCCMGLI VFVWLYNIVI IPKIVLFPHY EEGHIPGILI
60 70 80 90 100
IIFYGISIFC LVALVRASLT DPGRLPENPK IPHAERELWE LCNKCNLMRP
110 120 130 140 150
KRSHHCSRCG HCVRRMDHHC PWINNCVGED NHWLFLQLCF YTELLTCYAL
160 170 180 190 200
MFSFCHYYYF LPLKKRNLDL FVVRHELAIM RLAAFMGITM LVGITGLFYT
210 220 230 240 250
QLIGIITDTT SIEKMSNCCE EISRPRKPWQ QTFSEVFGTR WKILWFIPFR
260
QRQPLRVPYH FANHV
Length:265
Mass (Da):31,331
Last modified:November 22, 2005 - v2
Checksum:iBA3F428AAE4637DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67A → T in AAO27361 (PubMed:15229235).Curated1
Sequence conflicti67A → T in BAB32059 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY166674 mRNA Translation: AAO27361.1
AK020293 mRNA Translation: BAB32059.1
AL671005 Genomic DNA No translation available.
BC043110 mRNA Translation: AAH43110.1
CCDSiCCDS18294.1
RefSeqiNP_080923.2, NM_026647.3
XP_006538279.1, XM_006538216.3
XP_011248395.1, XM_011250093.2
XP_011248396.1, XM_011250094.2
XP_017175861.1, XM_017320372.1
XP_017175862.1, XM_017320373.1
UniGeneiMm.32047

Genome annotation databases

EnsembliENSMUST00000030110; ENSMUSP00000030110; ENSMUSG00000028403
ENSMUST00000107239; ENSMUSP00000102859; ENSMUSG00000028403
GeneIDi68268
KEGGimmu:68268
UCSCiuc008tkj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZDH21_MOUSE
AccessioniPrimary (citable) accession number: Q9D270
Secondary accession number(s): Q6EMK1, Q80XQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health