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Protein

Cystatin-11

Gene

Cst11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-11
Alternative name(s):
Cystatin-E11 Publication
Cystatin-related epididymal spermatogenic protein 21 Publication
Gene namesi
Name:Cst11Imported
Synonyms:Cres21 Publication, CSTE11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925490 Cst11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000665929 – 139Cystatin-11Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 102By similarity
Disulfide bondi115 ↔ 135By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9D269
PRIDEiQ9D269

PTM databases

PhosphoSitePlusiQ9D269

Expressioni

Tissue specificityi

Expressed in epididymis, where it localizes to the proximal caput and also part of the midcaput. Not detected in other tissues tested.2 Publications

Inductioni

Up-regulated by testicular factors. However, does not seem to be directly regulated by androgens or estrogen.2 Publications

Gene expression databases

BgeeiENSMUSG00000036958
CleanExiMM_CST11
ExpressionAtlasiQ9D269 baseline and differential
GenevisibleiQ9D269 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028934

Structurei

3D structure databases

ProteinModelPortaliQ9D269
SMRiQ9D269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ0B Eukaryota
ENOG4111EFC LUCA
GeneTreeiENSGT00910000144356
HOGENOMiHOG000231754
HOVERGENiHBG096361
InParanoidiQ9D269
KOiK13906
OMAiEMRRTTC
OrthoDBiEOG091G0TP1
PhylomeDBiQ9D269

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSWKATR LLLAILVALV AFSYQVKRKT FIRIEEVSAL ESSVKETLEY
60 70 80 90 100
VTDEYNKKSE DLYNFRILRI LKIMKQVTGH LEYHITVEMQ RTTCLKTETS
110 120 130
LCDIQKGELH KKIQCYFSVY AIPWVEVFKI LKKNCTDIS
Length:139
Mass (Da):16,217
Last modified:June 1, 2001 - v1
Checksum:iF228D9815FA32640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001265 mRNA Translation: DAA01199.1
AF454373 mRNA Translation: AAL51004.1
AK020300 mRNA Translation: BAB32061.1
BC100526 mRNA Translation: AAI00527.1
CCDSiCCDS16845.1
RefSeqiNP_084335.1, NM_030059.2
UniGeneiMm.99424

Genome annotation databases

EnsembliENSMUST00000028934; ENSMUSP00000028934; ENSMUSG00000036958
GeneIDi78240
KEGGimmu:78240
UCSCiuc008mtl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCST11_MOUSE
AccessioniPrimary (citable) accession number: Q9D269
Secondary accession number(s): Q7M731
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome