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Protein

Cystatin-11

Gene

Cst11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-11
Gene namesi
Name:Cst11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925490. Cst11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000665929 – 139Cystatin-11Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 102By similarity
Disulfide bondi115 ↔ 135By similarity
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9D269.
PRIDEiQ9D269.

PTM databases

PhosphoSitePlusiQ9D269.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036958.
CleanExiMM_CST11.
ExpressionAtlasiQ9D269. baseline and differential.
GenevisibleiQ9D269. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028934.

Structurei

3D structure databases

ProteinModelPortaliQ9D269.
SMRiQ9D269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 80Secondary area of contactSequence analysis5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ0B. Eukaryota.
ENOG4111EFC. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG096361.
InParanoidiQ9D269.
KOiK13906.
OMAiEMRRTTC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ9D269.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSWKATR LLLAILVALV AFSYQVKRKT FIRIEEVSAL ESSVKETLEY
60 70 80 90 100
VTDEYNKKSE DLYNFRILRI LKIMKQVTGH LEYHITVEMQ RTTCLKTETS
110 120 130
LCDIQKGELH KKIQCYFSVY AIPWVEVFKI LKKNCTDIS
Length:139
Mass (Da):16,217
Last modified:June 1, 2001 - v1
Checksum:iF228D9815FA32640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020300 mRNA. Translation: BAB32061.1.
CCDSiCCDS16845.1.
RefSeqiNP_084335.1. NM_030059.2.
UniGeneiMm.99424.

Genome annotation databases

EnsembliENSMUST00000028934; ENSMUSP00000028934; ENSMUSG00000036958.
GeneIDi78240.
KEGGimmu:78240.
UCSCiuc008mtl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020300 mRNA. Translation: BAB32061.1.
CCDSiCCDS16845.1.
RefSeqiNP_084335.1. NM_030059.2.
UniGeneiMm.99424.

3D structure databases

ProteinModelPortaliQ9D269.
SMRiQ9D269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028934.

PTM databases

PhosphoSitePlusiQ9D269.

Proteomic databases

PaxDbiQ9D269.
PRIDEiQ9D269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028934; ENSMUSP00000028934; ENSMUSG00000036958.
GeneIDi78240.
KEGGimmu:78240.
UCSCiuc008mtl.1. mouse.

Organism-specific databases

CTDi140880.
MGIiMGI:1925490. Cst11.

Phylogenomic databases

eggNOGiENOG410IZ0B. Eukaryota.
ENOG4111EFC. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG096361.
InParanoidiQ9D269.
KOiK13906.
OMAiEMRRTTC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ9D269.

Miscellaneous databases

PROiQ9D269.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036958.
CleanExiMM_CST11.
ExpressionAtlasiQ9D269. baseline and differential.
GenevisibleiQ9D269. MM.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCST11_MOUSE
AccessioniPrimary (citable) accession number: Q9D269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.