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Protein

Cystatin-11

Gene

Cst11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-11
Alternative name(s):
Cystatin-E11 Publication
Cystatin-related epididymal spermatogenic protein 21 Publication
Gene namesi
Name:Cst11Imported
Synonyms:Cres21 Publication, CSTE11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925490. Cst11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000665929 – 139Cystatin-11Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 102By similarity
Disulfide bondi115 ↔ 135By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9D269.
PRIDEiQ9D269.

PTM databases

PhosphoSitePlusiQ9D269.

Expressioni

Tissue specificityi

Expressed in epididymis, where it localizes to the proximal caput and also part of the midcaput. Not detected in other tissues tested.2 Publications

Inductioni

Up-regulated by testicular factors. However, does not seem to be directly regulated by androgens or estrogen.2 Publications

Gene expression databases

BgeeiENSMUSG00000036958.
CleanExiMM_CST11.
ExpressionAtlasiQ9D269. baseline and differential.
GenevisibleiQ9D269. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028934.

Structurei

3D structure databases

ProteinModelPortaliQ9D269.
SMRiQ9D269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ0B. Eukaryota.
ENOG4111EFC. LUCA.
GeneTreeiENSGT00900000141055.
HOGENOMiHOG000231754.
HOVERGENiHBG096361.
InParanoidiQ9D269.
KOiK13906.
OMAiEMRRTTC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ9D269.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
SMARTiView protein in SMART
SM00043. CY. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSWKATR LLLAILVALV AFSYQVKRKT FIRIEEVSAL ESSVKETLEY
60 70 80 90 100
VTDEYNKKSE DLYNFRILRI LKIMKQVTGH LEYHITVEMQ RTTCLKTETS
110 120 130
LCDIQKGELH KKIQCYFSVY AIPWVEVFKI LKKNCTDIS
Length:139
Mass (Da):16,217
Last modified:June 1, 2001 - v1
Checksum:iF228D9815FA32640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001265 mRNA. Translation: DAA01199.1.
AF454373 mRNA. Translation: AAL51004.1.
AK020300 mRNA. Translation: BAB32061.1.
BC100526 mRNA. Translation: AAI00527.1.
CCDSiCCDS16845.1.
RefSeqiNP_084335.1. NM_030059.2.
UniGeneiMm.99424.

Genome annotation databases

EnsembliENSMUST00000028934; ENSMUSP00000028934; ENSMUSG00000036958.
GeneIDi78240.
KEGGimmu:78240.
UCSCiuc008mtl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCST11_MOUSE
AccessioniPrimary (citable) accession number: Q9D269
Secondary accession number(s): Q7M731
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: January 31, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families