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Q9D244 (RNAS6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease K6

Short name=RNase K6
EC=3.1.27.-
Gene names
Name:Rnase6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pyrimidine specific nuclease with a preference for U By similarity.

Tissue specificity

Expression detected in kidney, skeletal muscle, heart, bone marrow and spleen. Ref.1

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Biophysicochemical properties

Kinetic parameters:

KM=2.1 µM for tRNA Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 153126Ribonuclease K6
PRO_0000030900

Regions

Region64 – 685Substrate binding By similarity

Sites

Active site411Proton acceptor By similarity
Active site1481Proton donor By similarity
Binding site891Substrate By similarity

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation851N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 107 By similarity
Disulfide bond63 ↔ 117 By similarity
Disulfide bond81 ↔ 132 By similarity
Disulfide bond88 ↔ 95 By similarity

Experimental info

Sequence conflict421I → V in BAB32143. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9D244 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 84A6C788AEE7CA05

FASTA15317,675
        10         20         30         40         50         60 
MVVDLPRYLP LLLLLELWEP MYLLCSQPKG LSRAHWFEIQ HIQTSRQPCN TAMRGVNNYT 

        70         80         90        100        110        120 
QHCKQINTFL HESFQNVAAT CSLHNITCKN GRKNCHESAE PVKMTDCSHT GGAYPNCRYS 

       130        140        150 
SDKQYKFFIV ACEHPKKEDP PYQLVPVHLD KIV 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents."
Dyer K.D., Rosenberg H.F., Zhang J.
J. Mol. Evol. 59:657-665(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Urinary bladder.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY545655 mRNA. Translation: AAS48640.1.
AK020595 mRNA. Translation: BAB32143.1.
BC094892 mRNA. Translation: AAH94892.1.
BC132632 mRNA. Translation: AAI32633.1.
CCDSCCDS27037.1.
RefSeqNP_084374.2. NM_030098.2.
XP_006519761.1. XM_006519698.1.
UniGeneMm.103835.

3D structure databases

ProteinModelPortalQ9D244.
SMRQ9D244. Positions 27-153.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9D244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID78416.
KEGGmmu:78416.

Organism-specific databases

CTD6039.
MGIMGI:1925666. Rnase6.

Phylogenomic databases

eggNOGNOG45773.
HOGENOMHOG000276882.
HOVERGENHBG008396.
InParanoidA2RTT6.
KOK01172.
PhylomeDBQ9D244.

Gene expression databases

CleanExMM_RNASE6.
GenevestigatorQ9D244.

Family and domain databases

Gene3D3.10.130.10. 1 hit.
InterProIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERPTHR11437. PTHR11437. 1 hit.
PfamPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSPR00794. RIBONUCLEASE.
ProDomPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMSSF54076. SSF54076. 1 hit.
PROSITEPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio348836.
PROQ9D244.
SOURCESearch...

Entry information

Entry nameRNAS6_MOUSE
AccessionPrimary (citable) accession number: Q9D244
Secondary accession number(s): A2RTT6, Q6QDX5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot