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Q9D244

- RNAS6_MOUSE

UniProt

Q9D244 - RNAS6_MOUSE

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Protein

Ribonuclease K6

Gene

Rnase6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Pyrimidine specific nuclease with a preference for U.By similarity

Kineticsi

  1. KM=2.1 µM for tRNA1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptorBy similarity
Binding sitei89 – 891SubstrateBy similarity
Active sitei148 – 1481Proton donorBy similarity

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease K6 (EC:3.1.27.-)
Short name:
RNase K6
Gene namesi
Name:Rnase6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1925666. Rnase6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 153126Ribonuclease K6PRO_0000030900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 107By similarity
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi63 ↔ 117By similarity
Disulfide bondi81 ↔ 132By similarity
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi88 ↔ 95By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9D244.

Expressioni

Tissue specificityi

Expression detected in kidney, skeletal muscle, heart, bone marrow and spleen.1 Publication

Gene expression databases

CleanExiMM_RNASE6.
GenevestigatoriQ9D244.

Structurei

3D structure databases

ProteinModelPortaliQ9D244.
SMRiQ9D244. Positions 27-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 685Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45773.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiQ9D244.
KOiK01172.
PhylomeDBiQ9D244.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D244-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVDLPRYLP LLLLLELWEP MYLLCSQPKG LSRAHWFEIQ HIQTSRQPCN
60 70 80 90 100
TAMRGVNNYT QHCKQINTFL HESFQNVAAT CSLHNITCKN GRKNCHESAE
110 120 130 140 150
PVKMTDCSHT GGAYPNCRYS SDKQYKFFIV ACEHPKKEDP PYQLVPVHLD

KIV
Length:153
Mass (Da):17,675
Last modified:July 5, 2005 - v2
Checksum:i84A6C788AEE7CA05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421I → V in BAB32143. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY545655 mRNA. Translation: AAS48640.1.
AK020595 mRNA. Translation: BAB32143.1.
BC094892 mRNA. Translation: AAH94892.1.
BC132632 mRNA. Translation: AAI32633.1.
CCDSiCCDS27037.1.
RefSeqiNP_084374.2. NM_030098.2.
XP_006519761.1. XM_006519698.1.
UniGeneiMm.103835.

Genome annotation databases

GeneIDi78416.
KEGGimmu:78416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY545655 mRNA. Translation: AAS48640.1 .
AK020595 mRNA. Translation: BAB32143.1 .
BC094892 mRNA. Translation: AAH94892.1 .
BC132632 mRNA. Translation: AAI32633.1 .
CCDSi CCDS27037.1.
RefSeqi NP_084374.2. NM_030098.2.
XP_006519761.1. XM_006519698.1.
UniGenei Mm.103835.

3D structure databases

ProteinModelPortali Q9D244.
SMRi Q9D244. Positions 27-153.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9D244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 78416.
KEGGi mmu:78416.

Organism-specific databases

CTDi 6039.
MGIi MGI:1925666. Rnase6.

Phylogenomic databases

eggNOGi NOG45773.
HOGENOMi HOG000276882.
HOVERGENi HBG008396.
InParanoidi Q9D244.
KOi K01172.
PhylomeDBi Q9D244.

Miscellaneous databases

NextBioi 348836.
PROi Q9D244.
SOURCEi Search...

Gene expression databases

CleanExi MM_RNASE6.
Genevestigatori Q9D244.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents."
    Dyer K.D., Rosenberg H.F., Zhang J.
    J. Mol. Evol. 59:657-665(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Pancreas.

Entry informationi

Entry nameiRNAS6_MOUSE
AccessioniPrimary (citable) accession number: Q9D244
Secondary accession number(s): A2RTT6, Q6QDX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3