Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-2-microglobulin

Gene

B2m

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulinSAAS annotation
Gene namesi
Name:B2mImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88127. B2m.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MHC ISAAS annotation, SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500432464921 – 119Beta-2-microglobulinSequence analysisAdd BLAST99

Proteomic databases

PaxDbiQ9D239.
PeptideAtlasiQ9D239.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ9D239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 114Ig-likeInterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
HOVERGENiHBG006197.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PANTHERiPTHR19944:SF81. PTHR19944:SF81. 1 hit.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSVTLVFL VLVTLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF
60 70 80 90 100
HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC
110
RVKHASMAEP ETVYWDRDM
Length:119
Mass (Da):13,794
Last modified:June 1, 2001 - v1
Checksum:iCC16F98679C617FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020632 mRNA. Translation: BAB32158.1.
UniGeneiMm.163.

Similar proteinsi

Entry informationi

Entry nameiQ9D239_MOUSE
AccessioniPrimary (citable) accession number: Q9D239
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)