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Protein

Beta-2-microglobulin

Gene

B2m

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.SAAS annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulinSAAS annotation
Gene namesi
Name:B2mImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88127. B2m.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MHC ISAAS annotation, SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 11999Beta-2-microglobulinSequence analysisPRO_5004324649Add
BLAST

Proteomic databases

PaxDbiQ9D239.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.SAAS annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099534.

Structurei

3D structure databases

ProteinModelPortaliQ9D239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11490Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.SAAS annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
HOVERGENiHBG006197.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSVTLVFL VLVTLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF
60 70 80 90 100
HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC
110
RVKHASMAEP ETVYWDRDM
Length:119
Mass (Da):13,794
Last modified:June 1, 2001 - v1
Checksum:iCC16F98679C617FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020632 mRNA. Translation: BAB32158.1.
UniGeneiMm.163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020632 mRNA. Translation: BAB32158.1.
UniGeneiMm.163.

3D structure databases

ProteinModelPortaliQ9D239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099534.

Proteomic databases

PaxDbiQ9D239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88127. B2m.

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
HOVERGENiHBG006197.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.

Entry informationi

Entry nameiQ9D239_MOUSE
AccessioniPrimary (citable) accession number: Q9D239
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.