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Protein

Keratin-associated protein 5-3

Gene

Krtap5-3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-3By similarity
Gene namesi
Name:Krtap5-3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924465. Krtap5-3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003616591 – 196Keratin-associated protein 5-3Add BLAST196

Proteomic databases

PaxDbiQ9D226.
PRIDEiQ9D226.

Interactioni

Subunit structurei

Interacts with hair keratins.Curated

Structurei

3D structure databases

ProteinModelPortaliQ9D226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 1714
Repeati20 – 2324

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 232 X 4 AA repeats of C-C-X-P10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 133Cys-richSequence analysisAdd BLAST131
Compositional biasi146 – 174Leu-richSequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the KRTAP type 5 family.By similarity

Keywords - Domaini

Repeat

Sequencei

Sequence statusi: Complete.

Q9D226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCCGCCGGC GSSCCKPVCC CVPVCSCSSC GGCKGGCSSC GGCGSCGGCK
60 70 80 90 100
GGCGSCGGCG SCGGCKGGCG SCGGCGSCGG CKGGCGSCGG CGSCGGCKGG
110 120 130 140 150
CGSCGGCGSC GGCKGGCSSC GGCGSCGAAS PSCVSPAAAS PAVQALLLPV
160 170 180 190
QLLQALLLPA QLLLVQLLLS LLLLHDCGSS CCPMSCSLPI YCQREI
Length:196
Mass (Da):17,777
Last modified:June 1, 2001 - v1
Checksum:i2136738FD496D815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020699 mRNA. Translation: BAB32180.1.
UniGeneiMm.462993.

Similar proteinsi

Entry informationi

Entry nameiKRA53_MOUSE
AccessioniPrimary (citable) accession number: Q9D226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome