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Q9D219 (BCL9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-cell CLL/lymphoma 9 protein

Short name=B-cell lymphoma 9 protein
Short name=Bcl-9
Gene names
Name:Bcl9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1425 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes beta-catenin's transcriptional activity. Involved in signal transduction through the Wnt pathway By similarity. Ref.1

Subunit structure

Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the interaction with PYGO1 increases PYGO1 affinity to histone H3 methylated at 'Lys 4' By similarity.

Subcellular location

Nucleus Ref.1.

Sequence similarities

Belongs to the BCL9 family.

Sequence caution

The sequence AAH19641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14251425B-cell CLL/lymphoma 9 protein
PRO_0000064886

Regions

Region177 – 20529Interacts with PYGO1 By similarity
Region358 – 37417Interacts with CTNNB1 By similarity
Compositional bias231 – 13771147Pro-rich
Compositional bias1379 – 142446Met-rich

Amino acid modifications

Modified residue1041Phosphoserine Ref.5
Modified residue1721Phosphothreonine By similarity
Modified residue3151Phosphothreonine By similarity
Modified residue3181Phosphoserine By similarity
Modified residue3521Phosphoserine Ref.4
Modified residue6861Phosphoserine Ref.5
Modified residue8431N6-acetyllysine Ref.6
Modified residue9061Phosphoserine By similarity
Modified residue9161Phosphoserine By similarity

Experimental info

Sequence conflict11341M → V in BAB32190. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9D219 [UniParc].

Last modified September 27, 2005. Version 3.
Checksum: 77347CF56FC4A815

FASTA1,425148,971
        10         20         30         40         50         60 
MHPSNPKVRS SPSGNTQSSP KSKQEVMVRP PTVMSPSGNP QLDSKFSNQG KPGGSASQSQ 

        70         80         90        100        110        120 
PSPCDSKSGG HTPKALPGPG GSMGLKNGAG NGAKGKGKRE RSISADSFDQ RDPGTPNDDS 

       130        140        150        160        170        180 
DIKECNSADH IKSQESQHTP HSMTPSTATA PRSSTPSHGQ TPAPEPISAQ KTPAKVVYVF 

       190        200        210        220        230        240 
STEMANKAAE AVLKGQVETI VSFHIQNISN SKSERSTAPL NTQIPTLRND PKPLPQQPPA 

       250        260        270        280        290        300 
PANQDQNSSQ NARLQPTPPI QAPAPKPTAA PRPLDRESPG VENKLIPPVG SPGSSTPLPP 

       310        320        330        340        350        360 
DGTGPNSTPN NRAVTPVSQG SNSSSADPKA PPPPPVSGGE PPTLGENPDG LSQEQLEHRE 

       370        380        390        400        410        420 
RSLQTLRDIQ RMLFPDEKEF TAGQTGGPQQ NTGVLDGPQK KPDGPIQAMM SQSQSLGKGP 

       430        440        450        460        470        480 
GPRTDVGAPF GPQGHRDVPF SPDEMVPPNM SSQSGPIGPD HLDHMTPEQI AWLKLQQEFY 

       490        500        510        520        530        540 
EEKRRKQEQV VVQQCSLQDM MVHQHGPRGV VRGPPPPYQM APGEGWAPGA EPFPDGINIS 

       550        560        570        580        590        600 
HSLPPRGMAP HPNMPGSQMR LPGFAGMINS EMEGPNVPNP ASRPGLSGVS WPDDVPKIPD 

       610        620        630        640        650        660 
GRNFPPGQGV FSGPGRGERF PNPQGLSEEM FQQQLAEKQL ALPPGMSMEG IRPGMEMNRM 

       670        680        690        700        710        720 
IPGSQRHMEP GSNPIFPRIP VEGPLSPSRG DFPKGMPPQI GPGRELEFGM VPGGMKGEVN 

       730        740        750        760        770        780 
LNVNMGSSSQ MIPQKMREAG AGPEEMMKLR PGSSEMLPAQ QKMVPLPFGE HPQQEYGVGP 

       790        800        810        820        830        840 
RPFLPMSQGP GSNSGLRNLR EPIGPDQRTN SRLSHMPPLP LNPSSNPTSL STAPPVQRGL 

       850        860        870        880        890        900 
GRKPLDISVA GSQVHSPGIN PLKSPTMHQV QSPMLGSPSG NLKSPQTPSQ LAGMLAGPAA 

       910        920        930        940        950        960 
AASIKSPPVL GSAAASPVHL KSPSLPAPSP GWTSSPKPPL QSPGIPPNHK APLTMASPAM 

       970        980        990       1000       1010       1020 
LGSVESGGPP PPTASQPASV NIPGSLPSST PYPMPPEPTL SQNPLSIMMS RMSKFAMPSS 

      1030       1040       1050       1060       1070       1080 
TPLYHDAIKT VASSDDDSPP ARSPNLPSMN SMPGMGINTQ NPRISGPNPV VPMPTLSPMG 

      1090       1100       1110       1120       1130       1140 
MTQPLSHSNQ MPSPNAMGPS IPPHGVPMGP GLMSHNPIMG HGSQEPPMVP QGRMGFPQGF 

      1150       1160       1170       1180       1190       1200 
PPVQSPPQQV PFPHNGPTGG QGNFPGGIGF PGEGPLGRPS NLPQSSADPA LCKPGGPGAP 

      1210       1220       1230       1240       1250       1260 
DSFTVLGNSM PSVFTDPDLQ EVIRPGATGI PEFDLSRIIP SEKPSQTLQY FPRGEVPGRK 

      1270       1280       1290       1300       1310       1320 
QPQGPGPGFS HMQGMMSDQA PRMGLALPGM GGPGPVGTPD IPLGTSPSMP GHNPMRPPAF 

      1330       1340       1350       1360       1370       1380 
LQQGMMGPHH RMMSPAQSTV PGPATLMTNP AAAVGMIPGK DRGPAGLYTH PGPVGSPGMM 

      1390       1400       1410       1420 
MSMQGMMGPQ QNIMIPPQMR PRGMAADVGM GGFSQGPGNP GNMMF 

« Hide

References

« Hide 'large scale' references
[1]"Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions."
Brembeck F.H., Schwarz-Romond T., Bakkers J., Wilhelm S., Hammerschmidt M., Birchmeier W.
Genes Dev. 18:2225-2230(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Mammary gland.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 484-1425.
Strain: C57BL/6J.
Tissue: Heart and Spinal cord.
[4]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104 AND SER-686, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-843, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY296061 mRNA. Translation: AAQ62699.1.
BC019641 mRNA. Translation: AAH19641.1. Different initiation.
BC137850 mRNA. Translation: AAI37851.1.
AK020724 mRNA. Translation: BAB32190.1.
AK084676 mRNA. Translation: BAC39248.1.
CCDSCCDS17654.1.
RefSeqNP_084209.3. NM_029933.4.
XP_006502351.1. XM_006502288.1.
XP_006502352.1. XM_006502289.1.
XP_006502353.1. XM_006502290.1.
UniGeneMm.226175.
Mm.482931.

3D structure databases

ProteinModelPortalQ9D219.
SMRQ9D219. Positions 174-205, 348-374.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000046152.

PTM databases

PhosphoSiteQ9D219.

Proteomic databases

PaxDbQ9D219.
PRIDEQ9D219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046521; ENSMUSP00000046152; ENSMUSG00000038256.
ENSMUST00000166341; ENSMUSP00000131692; ENSMUSG00000038256.
GeneID77578.
KEGGmmu:77578.
UCSCuc008qos.1. mouse.

Organism-specific databases

CTD607.
MGIMGI:1924828. Bcl9.

Phylogenomic databases

eggNOGNOG74241.
GeneTreeENSGT00730000110915.
HOGENOMHOG000060118.
HOVERGENHBG031116.
InParanoidB2RQC0.
OMAMGSNPQM.
OrthoDBEOG7327N1.
PhylomeDBQ9D219.
TreeFamTF331144.

Gene expression databases

BgeeQ9D219.
CleanExMM_BCL9.
GenevestigatorQ9D219.

Family and domain databases

InterProIPR015668. Bcl-9.
IPR024670. BCL9_beta-catenin-bd_dom.
[Graphical view]
PANTHERPTHR15185. PTHR15185. 1 hit.
PfamPF11502. BCL9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio347136.
PROQ9D219.
SOURCESearch...

Entry information

Entry nameBCL9_MOUSE
AccessionPrimary (citable) accession number: Q9D219
Secondary accession number(s): B2RQC0 expand/collapse secondary AC list , Q67FX9, Q8BUJ8, Q8VE74
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot