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Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Gene

Lingo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.By similarity1 Publication1 Publication

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: MGI

GO - Biological processi

  • axonogenesis Source: GO_Central
  • central nervous system neuron development Source: MGI
  • negative regulation of oligodendrocyte differentiation Source: MGI
  • neuron projection development Source: MGI
  • protein kinase B signaling Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-193634. Axonal growth inhibition (RHOA activation).

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Alternative name(s):
Leucine-rich repeat neuronal protein 1
Leucine-rich repeat neuronal protein 6A
Gene namesi
Name:Lingo1
Synonyms:Lern1, Lrrn6a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915522. Lingo1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 555ExtracellularSequence analysisAdd BLAST520
Transmembranei556 – 576HelicalSequence analysisAdd BLAST21
Topological domaini577 – 614CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

In mice lacking Lingo1 and MPTP-intoxicated, a model for Parkinson disease, the dopaminergic neurons survival is increased and behavioral abnormalities reduced.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000032864336 – 614Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 42PROSITE-ProRule annotation
Disulfide bondi40 ↔ 51PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi335N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi367 ↔ 390PROSITE-ProRule annotation
Disulfide bondi369 ↔ 415PROSITE-ProRule annotation
Disulfide bondi440 ↔ 491PROSITE-ProRule annotation
Glycosylationi486N-linked (GlcNAc...)Sequence analysis1
Glycosylationi536N-linked (GlcNAc...)Sequence analysis1
Modified residuei596PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated. Contains predominantly high-mannose glycans (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9D1T0.
PaxDbiQ9D1T0.
PRIDEiQ9D1T0.

PTM databases

iPTMnetiQ9D1T0.
PhosphoSitePlusiQ9D1T0.

Expressioni

Tissue specificityi

Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.2 Publications

Developmental stagei

Expressed broadly at high levels in the whole embryo and becomes progressively restricted to the central nervous system by E14.5. Extensively expressed across the central nervous system through late embryogenesis and during postnatal development, with a peak of expression around the first week after birth.2 Publications

Inductioni

Up-regulated in brain from MPTP-intoxicated mice, a model for Parkinson disease.1 Publication

Gene expression databases

BgeeiENSMUSG00000049556.
ExpressionAtlasiQ9D1T0. baseline and differential.
GenevisibleiQ9D1T0. MM.

Interactioni

Subunit structurei

Homotetramer. Forms a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (By similarity). Interacts with NGRF and MYT1L (PubMed:18186492). Interacts with RTN4R (PubMed:18186492, PubMed:22923615).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AppP120232EBI-2012981,EBI-78814

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: MGI

Protein-protein interaction databases

DIPiDIP-46968N.
IntActiQ9D1T0. 1 interactor.
STRINGi10090.ENSMUSP00000059050.

Structurei

3D structure databases

ProteinModelPortaliQ9D1T0.
SMRiQ9D1T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 65LRRNTAdd BLAST30
Repeati66 – 87LRR 1Add BLAST22
Repeati90 – 111LRR 2Add BLAST22
Repeati114 – 135LRR 3Add BLAST22
Repeati138 – 159LRR 4Add BLAST22
Repeati162 – 183LRR 5Add BLAST22
Repeati186 – 207LRR 6Add BLAST22
Repeati210 – 231LRR 7Add BLAST22
Repeati258 – 279LRR 8Add BLAST22
Repeati282 – 303LRR 9Add BLAST22
Repeati306 – 327LRR 10Add BLAST22
Repeati330 – 351LRR 11Add BLAST22
Domaini363 – 417LRRCTAdd BLAST55
Domaini405 – 507Ig-like C2-typeAdd BLAST103

Domaini

The intracellular domain of LINGO1 interacts with MYT1L.1 Publication

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ9D1T0.
PhylomeDBiQ9D1T0.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAGGMRSMP SPLLACWQPI LLLVLGSVLS GSATGCPPRC ECSAQDRAVL
60 70 80 90 100
CHRKRFVAVP EGIPTETRLL DLGKNRIKTL NQDEFASFPH LEELELNENI
110 120 130 140 150
VSAVEPGAFN NLFNLRTLGL RSNRLKLIPL GVFTGLSNLT KLDISENKIV
160 170 180 190 200
ILLDYMFQDL YNLKSLEVGD NDLVYISHRA FSGLNSLEQL TLEKCNLTSI
210 220 230 240 250
PTEALSHLHG LIVLRLRHLN INAIRDYSFK RLYRLKVLEI SHWPYLDTMT
260 270 280 290 300
PNCLYGLNLT SLSITHCNLT AVPYLAVRHL VYLRFLNLSY NPIGTIEGSM
310 320 330 340 350
LHELLRLQEI QLVGGQLAVV EPYAFRGLNY LRVLNVSGNQ LTTLEESAFH
360 370 380 390 400
SVGNLETLIL DSNPLACDCR LLWVFRRRWR LNFNRQQPTC ATPEFVQGKE
410 420 430 440 450
FKDFPDVLLP NYFTCRRAHI RDRKAQQVFV DEGHTVQFVC RADGDPPPAI
460 470 480 490 500
LWLSPRKHLV SAKSNGRLTV FPDGTLEVRY AQVQDNGTYL CIAANAGGND
510 520 530 540 550
SMPAHLHVRS YSPDWPHQPN KTFAFISNQP GEGEANSTRA TVPFPFDIKT
560 570 580 590 600
LIIATTMGFI SFLGVVLFCL VLLFLWSRGK GNTKHNIEIE YVPRKSDAGI
610
SSADAPRKFN MKMI
Length:614
Mass (Da):69,101
Last modified:June 1, 2001 - v1
Checksum:i41CFF40C21335681
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti491C → G in AAQ97219 (PubMed:14686891).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027262 mRNA. Translation: BAB32403.1.
AK163538 mRNA. Translation: BAE37388.1.
BC052384 mRNA. Translation: AAH52384.2.
BC065696 mRNA. Translation: AAH65696.1.
AY324324 mRNA. Translation: AAQ97219.1.
CCDSiCCDS23209.1.
RefSeqiNP_001298005.1. NM_001311076.1.
NP_851419.1. NM_181074.4.
XP_006511151.1. XM_006511088.3.
XP_006511152.1. XM_006511089.3.
XP_006511153.1. XM_006511090.3.
XP_017168822.1. XM_017313333.1.
XP_017168823.1. XM_017313334.1.
XP_017168824.1. XM_017313335.1.
XP_017168825.1. XM_017313336.1.
UniGeneiMm.246605.

Genome annotation databases

EnsembliENSMUST00000053568; ENSMUSP00000059050; ENSMUSG00000049556.
ENSMUST00000114247; ENSMUSP00000109885; ENSMUSG00000049556.
ENSMUST00000210032; ENSMUSP00000148179; ENSMUSG00000049556.
GeneIDi235402.
KEGGimmu:235402.
UCSCiuc009pti.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027262 mRNA. Translation: BAB32403.1.
AK163538 mRNA. Translation: BAE37388.1.
BC052384 mRNA. Translation: AAH52384.2.
BC065696 mRNA. Translation: AAH65696.1.
AY324324 mRNA. Translation: AAQ97219.1.
CCDSiCCDS23209.1.
RefSeqiNP_001298005.1. NM_001311076.1.
NP_851419.1. NM_181074.4.
XP_006511151.1. XM_006511088.3.
XP_006511152.1. XM_006511089.3.
XP_006511153.1. XM_006511090.3.
XP_017168822.1. XM_017313333.1.
XP_017168823.1. XM_017313334.1.
XP_017168824.1. XM_017313335.1.
XP_017168825.1. XM_017313336.1.
UniGeneiMm.246605.

3D structure databases

ProteinModelPortaliQ9D1T0.
SMRiQ9D1T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46968N.
IntActiQ9D1T0. 1 interactor.
STRINGi10090.ENSMUSP00000059050.

PTM databases

iPTMnetiQ9D1T0.
PhosphoSitePlusiQ9D1T0.

Proteomic databases

MaxQBiQ9D1T0.
PaxDbiQ9D1T0.
PRIDEiQ9D1T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053568; ENSMUSP00000059050; ENSMUSG00000049556.
ENSMUST00000114247; ENSMUSP00000109885; ENSMUSG00000049556.
ENSMUST00000210032; ENSMUSP00000148179; ENSMUSG00000049556.
GeneIDi235402.
KEGGimmu:235402.
UCSCiuc009pti.1. mouse.

Organism-specific databases

CTDi84894.
MGIiMGI:1915522. Lingo1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ9D1T0.
PhylomeDBiQ9D1T0.
TreeFamiTF334360.

Enzyme and pathway databases

ReactomeiR-MMU-193634. Axonal growth inhibition (RHOA activation).

Miscellaneous databases

ChiTaRSiLingo1. mouse.
PROiQ9D1T0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049556.
ExpressionAtlasiQ9D1T0. baseline and differential.
GenevisibleiQ9D1T0. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIGO1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1T0
Secondary accession number(s): Q3TQJ4, Q6VVF9, Q7TT38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.