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Q9D1Q4

- DPM3_MOUSE

UniProt

Q9D1Q4 - DPM3_MOUSE

Protein

Dolichol-phosphate mannosyltransferase subunit 3

Gene

Dpm3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.By similarity

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate beta-D-mannosyltransferase activity Source: Ensembl

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: Ensembl
    2. mannosylation Source: GOC
    3. protein glycosylation Source: UniProtKB-UniPathway
    4. regulation of protein stability Source: Ensembl

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichol-phosphate mannosyltransferase subunit 3
    Alternative name(s):
    Dolichol-phosphate mannose synthase subunit 3
    Short name:
    DPM synthase subunit 3
    Dolichyl-phosphate beta-D-mannosyltransferase subunit 3
    Mannose-P-dolichol synthase subunit 3
    Short name:
    MPD synthase subunit 3
    Gene namesi
    Name:Dpm3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1915813. Dpm3.

    Subcellular locationi

    GO - Cellular componenti

    1. dolichol-phosphate-mannose synthase complex Source: HGNC
    2. integral component of endoplasmic reticulum membrane Source: HGNC

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9292Dolichol-phosphate mannosyltransferase subunit 3PRO_0000195001Add
    BLAST

    Proteomic databases

    PaxDbiQ9D1Q4.
    PRIDEiQ9D1Q4.

    Expressioni

    Gene expression databases

    BgeeiQ9D1Q4.
    GenevestigatoriQ9D1Q4.

    Interactioni

    Subunit structurei

    Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000103086.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DPM3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145469.
    GeneTreeiENSGT00390000008892.
    HOGENOMiHOG000038272.
    HOVERGENiHBG018968.
    InParanoidiQ9D1Q4.
    KOiK09659.
    OMAiYREVAWP.
    OrthoDBiEOG73540R.
    PhylomeDBiQ9D1Q4.
    TreeFamiTF300274.

    Family and domain databases

    InterProiIPR013174. DPM3.
    [Graphical view]
    PfamiPF08285. DPM3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D1Q4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKLTQWLWG LALLGSAWAA LTMGALGLEL PFPCREVLWP LPAYLLVSAG   50
    CYALGTVGYR VATFHDCEDA ARELQSQIVE ARADLARRGL RF 92
    Length:92
    Mass (Da):10,139
    Last modified:June 1, 2001 - v1
    Checksum:iB621E6E47337CC40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003223 mRNA. Translation: BAB22652.1.
    BC037761 mRNA. No translation available.
    CCDSiCCDS38487.1.
    RefSeqiNP_081043.1. NM_026767.4.
    XP_006502046.1. XM_006501983.1.
    UniGeneiMm.272927.

    Genome annotation databases

    EnsembliENSMUST00000040824; ENSMUSP00000040860; ENSMUSG00000042737.
    ENSMUST00000107462; ENSMUSP00000103086; ENSMUSG00000042737.
    GeneIDi68563.
    KEGGimmu:68563.
    UCSCiuc008pym.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003223 mRNA. Translation: BAB22652.1 .
    BC037761 mRNA. No translation available.
    CCDSi CCDS38487.1.
    RefSeqi NP_081043.1. NM_026767.4.
    XP_006502046.1. XM_006501983.1.
    UniGenei Mm.272927.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000103086.

    Proteomic databases

    PaxDbi Q9D1Q4.
    PRIDEi Q9D1Q4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040824 ; ENSMUSP00000040860 ; ENSMUSG00000042737 .
    ENSMUST00000107462 ; ENSMUSP00000103086 ; ENSMUSG00000042737 .
    GeneIDi 68563.
    KEGGi mmu:68563.
    UCSCi uc008pym.1. mouse.

    Organism-specific databases

    CTDi 54344.
    MGIi MGI:1915813. Dpm3.

    Phylogenomic databases

    eggNOGi NOG145469.
    GeneTreei ENSGT00390000008892.
    HOGENOMi HOG000038272.
    HOVERGENi HBG018968.
    InParanoidi Q9D1Q4.
    KOi K09659.
    OMAi YREVAWP.
    OrthoDBi EOG73540R.
    PhylomeDBi Q9D1Q4.
    TreeFami TF300274.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 327458.
    PROi Q9D1Q4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D1Q4.
    Genevestigatori Q9D1Q4.

    Family and domain databases

    InterProi IPR013174. DPM3.
    [Graphical view ]
    Pfami PF08285. DPM3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiDPM3_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3