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Protein

Dolichol-phosphate mannosyltransferase subunit 3

Gene

Dpm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.By similarity

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate beta-D-mannosyltransferase activity Source: Ensembl

GO - Biological processi

  1. GPI anchor biosynthetic process Source: MGI
  2. protein O-linked mannosylation Source: GO_Central
  3. regulation of protein stability Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_317373. Synthesis of dolichyl-phosphate mannose.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol-phosphate mannosyltransferase subunit 3
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 3
Short name:
DPM synthase subunit 3
Dolichyl-phosphate beta-D-mannosyltransferase subunit 3
Mannose-P-dolichol synthase subunit 3
Short name:
MPD synthase subunit 3
Gene namesi
Name:Dpm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915813. Dpm3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dolichol-phosphate-mannose synthase complex Source: HGNC
  2. endoplasmic reticulum Source: MGI
  3. endoplasmic reticulum membrane Source: GO_Central
  4. integral component of endoplasmic reticulum membrane Source: HGNC
  5. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Dolichol-phosphate mannosyltransferase subunit 3PRO_0000195001Add
BLAST

Proteomic databases

MaxQBiQ9D1Q4.
PaxDbiQ9D1Q4.
PRIDEiQ9D1Q4.

Expressioni

Gene expression databases

BgeeiQ9D1Q4.
GenevestigatoriQ9D1Q4.

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103086.

Family & Domainsi

Sequence similaritiesi

Belongs to the DPM3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145469.
GeneTreeiENSGT00390000008892.
HOGENOMiHOG000038272.
HOVERGENiHBG018968.
InParanoidiQ9D1Q4.
KOiK09659.
OMAiPCREVLW.
OrthoDBiEOG73540R.
PhylomeDBiQ9D1Q4.
TreeFamiTF300274.

Family and domain databases

InterProiIPR013174. DPM3.
[Graphical view]
PfamiPF08285. DPM3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D1Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLTQWLWG LALLGSAWAA LTMGALGLEL PFPCREVLWP LPAYLLVSAG
60 70 80 90
CYALGTVGYR VATFHDCEDA ARELQSQIVE ARADLARRGL RF
Length:92
Mass (Da):10,139
Last modified:May 31, 2001 - v1
Checksum:iB621E6E47337CC40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003223 mRNA. Translation: BAB22652.1.
BC037761 mRNA. No translation available.
CCDSiCCDS38487.1.
RefSeqiNP_081043.1. NM_026767.4.
XP_006502046.1. XM_006501983.1.
UniGeneiMm.272927.

Genome annotation databases

EnsembliENSMUST00000040824; ENSMUSP00000040860; ENSMUSG00000042737.
ENSMUST00000107462; ENSMUSP00000103086; ENSMUSG00000042737.
GeneIDi68563.
KEGGimmu:68563.
UCSCiuc008pym.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003223 mRNA. Translation: BAB22652.1.
BC037761 mRNA. No translation available.
CCDSiCCDS38487.1.
RefSeqiNP_081043.1. NM_026767.4.
XP_006502046.1. XM_006501983.1.
UniGeneiMm.272927.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103086.

Proteomic databases

MaxQBiQ9D1Q4.
PaxDbiQ9D1Q4.
PRIDEiQ9D1Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040824; ENSMUSP00000040860; ENSMUSG00000042737.
ENSMUST00000107462; ENSMUSP00000103086; ENSMUSG00000042737.
GeneIDi68563.
KEGGimmu:68563.
UCSCiuc008pym.1. mouse.

Organism-specific databases

CTDi54344.
MGIiMGI:1915813. Dpm3.

Phylogenomic databases

eggNOGiNOG145469.
GeneTreeiENSGT00390000008892.
HOGENOMiHOG000038272.
HOVERGENiHBG018968.
InParanoidiQ9D1Q4.
KOiK09659.
OMAiPCREVLW.
OrthoDBiEOG73540R.
PhylomeDBiQ9D1Q4.
TreeFamiTF300274.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiREACT_317373. Synthesis of dolichyl-phosphate mannose.

Miscellaneous databases

NextBioi327458.
PROiQ9D1Q4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D1Q4.
GenevestigatoriQ9D1Q4.

Family and domain databases

InterProiIPR013174. DPM3.
[Graphical view]
PfamiPF08285. DPM3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiDPM3_MOUSE
AccessioniPrimary (citable) accession number: Q9D1Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2002
Last sequence update: May 31, 2001
Last modified: March 31, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.