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Protein

M-phase phosphoprotein 6

Gene

Mphosph6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase phosphoprotein 6
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915783. Mphosph6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224381 – 161M-phase phosphoprotein 6Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111PhosphoserineBy similarity1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated in M (mitotic) phase.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D1Q1.
MaxQBiQ9D1Q1.
PaxDbiQ9D1Q1.
PeptideAtlasiQ9D1Q1.
PRIDEiQ9D1Q1.

PTM databases

iPTMnetiQ9D1Q1.
PhosphoSitePlusiQ9D1Q1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031843.
CleanExiMM_MPHOSPH6.
GenevisibleiQ9D1Q1. MM.

Interactioni

Subunit structurei

Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and SKIV2L2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034303.

Structurei

3D structure databases

ProteinModelPortaliQ9D1Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi117 – 134Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 35Poly-Glu4

Sequence similaritiesi

Belongs to the MPP6 family.Curated

Phylogenomic databases

eggNOGiKOG4531. Eukaryota.
ENOG4111K5Z. LUCA.
GeneTreeiENSGT00390000009212.
HOGENOMiHOG000007728.
HOVERGENiHBG031714.
InParanoidiQ9D1Q1.
KOiK12593.
OMAiNGDITPI.
OrthoDBiEOG091G0T3X.
PhylomeDBiQ9D1Q1.
TreeFamiTF323810.

Family and domain databases

InterProiIPR019324. MPP6.
[Graphical view]
PANTHERiPTHR13582. PTHR13582. 1 hit.
PfamiPF10175. MPP6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D1Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASERKTKLS KNLLRMKFMQ RGLDSETKKQ LEEEERKMIS DEHWYLDLPE
60 70 80 90 100
LKEKESFIVE EQSFSLCEDL LYGRMSFRGF NPEVEKLMLQ MNSKNRAEAA
110 120 130 140 150
EEDETVEVDV SDEEMARRYE TLVGTIGKKF VKKRDRANYE EDENGTIKAI
160
KPKKMFLKPQ D
Length:161
Mass (Da):19,086
Last modified:June 1, 2001 - v1
Checksum:i58762841641C0DC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003245 mRNA. Translation: BAB22664.1.
BC008161 mRNA. Translation: AAH08161.1.
CCDSiCCDS22702.1.
RefSeqiNP_081034.1. NM_026758.3.
UniGeneiMm.181836.

Genome annotation databases

EnsembliENSMUST00000034303; ENSMUSP00000034303; ENSMUSG00000031843.
GeneIDi68533.
KEGGimmu:68533.
UCSCiuc009npg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003245 mRNA. Translation: BAB22664.1.
BC008161 mRNA. Translation: AAH08161.1.
CCDSiCCDS22702.1.
RefSeqiNP_081034.1. NM_026758.3.
UniGeneiMm.181836.

3D structure databases

ProteinModelPortaliQ9D1Q1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034303.

PTM databases

iPTMnetiQ9D1Q1.
PhosphoSitePlusiQ9D1Q1.

Proteomic databases

EPDiQ9D1Q1.
MaxQBiQ9D1Q1.
PaxDbiQ9D1Q1.
PeptideAtlasiQ9D1Q1.
PRIDEiQ9D1Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034303; ENSMUSP00000034303; ENSMUSG00000031843.
GeneIDi68533.
KEGGimmu:68533.
UCSCiuc009npg.1. mouse.

Organism-specific databases

CTDi10200.
MGIiMGI:1915783. Mphosph6.

Phylogenomic databases

eggNOGiKOG4531. Eukaryota.
ENOG4111K5Z. LUCA.
GeneTreeiENSGT00390000009212.
HOGENOMiHOG000007728.
HOVERGENiHBG031714.
InParanoidiQ9D1Q1.
KOiK12593.
OMAiNGDITPI.
OrthoDBiEOG091G0T3X.
PhylomeDBiQ9D1Q1.
TreeFamiTF323810.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ9D1Q1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031843.
CleanExiMM_MPHOSPH6.
GenevisibleiQ9D1Q1. MM.

Family and domain databases

InterProiIPR019324. MPP6.
[Graphical view]
PANTHERiPTHR13582. PTHR13582. 1 hit.
PfamiPF10175. MPP6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPH6_MOUSE
AccessioniPrimary (citable) accession number: Q9D1Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.