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Protein

Cysteine and histidine-rich domain-containing protein 1

Gene

Chordc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity).By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Zinc 1PROSITE-ProRule annotation1
Metal bindingi10Zinc 1PROSITE-ProRule annotation1
Metal bindingi24Zinc 1PROSITE-ProRule annotation1
Metal bindingi27Zinc 2PROSITE-ProRule annotation1
Metal bindingi42Zinc 2PROSITE-ProRule annotation1
Metal bindingi43Zinc 2PROSITE-ProRule annotation1
Metal bindingi59Zinc 2PROSITE-ProRule annotation1
Metal bindingi64Zinc 1PROSITE-ProRule annotation1
Metal bindingi157Zinc 3PROSITE-ProRule annotation1
Metal bindingi162Zinc 3PROSITE-ProRule annotation1
Metal bindingi176Zinc 3PROSITE-ProRule annotation1
Metal bindingi179Zinc 4PROSITE-ProRule annotation1
Metal bindingi194Zinc 4PROSITE-ProRule annotation1
Metal bindingi195Zinc 4PROSITE-ProRule annotation1
Metal bindingi211Zinc 4PROSITE-ProRule annotation1
Metal bindingi216Zinc 3PROSITE-ProRule annotation1

GO - Molecular functioni

  • ADP binding Source: MGI
  • ATP binding Source: MGI
  • Hsp90 protein binding Source: MGI
  • zinc ion binding Source: MGI

GO - Biological processi

  • chaperone-mediated protein folding Source: UniProtKB
  • negative regulation of Rho-dependent protein serine/threonine kinase activity Source: UniProtKB
  • regulation of cellular response to heat Source: UniProtKB
  • regulation of centrosome duplication Source: UniProtKB

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and histidine-rich domain-containing protein 1
Alternative name(s):
CHORD domain-containing protein 1
Short name:
CHORD-containing protein 1
Short name:
Chp-1
Protein morgana
Gene namesi
Name:Chordc1
Synonyms:Chp1, Morgana
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914167 Chordc1

Pathology & Biotechi

Disruption phenotypei

Results in centrosome amplification and lethality. Cells become polyploid or undergo apoptosis. Embryos are no longer detected after 3.5 dpc.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003177712 – 331Cysteine and histidine-rich domain-containing protein 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei47PhosphothreonineBy similarity1
Modified residuei51PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D1P4
MaxQBiQ9D1P4
PaxDbiQ9D1P4
PeptideAtlasiQ9D1P4
PRIDEiQ9D1P4

PTM databases

iPTMnetiQ9D1P4
PhosphoSitePlusiQ9D1P4
SwissPalmiQ9D1P4

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in spleen, lung and brain (at protein level). Expressed in proliferating myoblasts and its expression remained steady after. Its expression undergoes diurnal and circadian changes in hypothalamus. Highly expressed during the dark-light transition (ZT20.5 (zeitgeber time 20.5) and ZT2.5).2 Publications

Developmental stagei

Weakly expressed at ZT8.5 and highly expressed at ZT14.5 at P6. At P6 highly expressed at ZT14.5 in hippocampus, prefrontal cortex and cerebellum. First detected and widely distributed at P1 and that continued throughout postnatal development. Expression is evident in the cortical plate (CP) at E17. Lower levels of expression is also evident in intermediate (IZ) and subventricular (SVZ) zones at this age. A more diffuse expression pattern is evident in early postnatal cortex with only slight differences in intensity throughout cortical layers. By P14, a more laminated distribution pattern becomes evident with a punctate distribution apparent in deep cortical layers.1 Publication

Inductioni

By Heat shock in a HSF1-dependent manner.1 Publication

Gene expression databases

BgeeiENSMUSG00000001774
ExpressionAtlasiQ9D1P4 baseline and differential
GenevisibleiQ9D1P4 MM

Interactioni

Subunit structurei

Interacts with HSP90AA1, HSP90AB1 and PPP5C. Interacts with ROCK1 and ROCK2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211809, 9 interactors
IntActiQ9D1P4, 3 interactors
MINTiQ9D1P4
STRINGi10090.ENSMUSP00000001825

Structurei

3D structure databases

ProteinModelPortaliQ9D1P4
SMRiQ9D1P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 64CHORD 1PROSITE-ProRule annotationAdd BLAST60
Domaini157 – 216CHORD 2PROSITE-ProRule annotationAdd BLAST60
Domaini227 – 316CSPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 77Interaction with PPP5C1 PublicationAdd BLAST76
Regioni65 – 316Interaction with HSP90AA1 and HSP90AB12 PublicationsAdd BLAST252

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1667 Eukaryota
ENOG410XPV6 LUCA
GeneTreeiENSGT00390000005180
HOGENOMiHOG000207093
HOVERGENiHBG052156
InParanoidiQ9D1P4
KOiK16729
OMAiQCRYDWH
OrthoDBiEOG091G0BY9
PhylomeDBiQ9D1P4
TreeFamiTF105394

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007051 CHORD_dom
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
PfamiView protein in Pfam
PF04968 CHORD, 2 hits
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51401 CHORD, 2 hits
PS51203 CS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLCYNRGC GQRFDPEANS DDACTYHPGV PVFHDALKGW SCCKRRTTDF
60 70 80 90 100
SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELSELKP KFQEHIIQAP
110 120 130 140 150
KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGSE EDKKEEDSDE
160 170 180 190 200
IKIGTSCKNG GCSKTYQGLQ SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS
210 220 230 240 250
DFNTFLAQEG CTRGKHVWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS
260 270 280 290 300
LPELSQVEAN STLLNVHIVF EGEKEFHQNV KLWGVIDVKR SYVTMTATKI
310 320 330
EITMRKAEPM QWASLELPTT KKQEKQKDIA D
Length:331
Mass (Da):37,351
Last modified:June 1, 2001 - v1
Checksum:i8E02FD5F4EB89BB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003259 mRNA Translation: BAB22675.1
AK012747 mRNA Translation: BAB28444.1
AK132696 mRNA Translation: BAE21307.1
BC018374 mRNA Translation: AAH18374.1
CCDSiCCDS22842.1
RefSeqiNP_080120.1, NM_025844.2
UniGeneiMm.103534

Genome annotation databases

EnsembliENSMUST00000001825; ENSMUSP00000001825; ENSMUSG00000001774
GeneIDi66917
KEGGimmu:66917
UCSCiuc009ogm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCHRD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1P4
Secondary accession number(s): Q9CSI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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