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Q9D1M7

- FKB11_MOUSE

UniProt

Q9D1M7 - FKB11_MOUSE

Protein

Peptidyl-prolyl cis-trans isomerase FKBP11

Gene

Fkbp11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP11 (EC:5.2.1.8)
    Short name:
    PPIase FKBP11
    Alternative name(s):
    19 kDa FK506-binding protein
    Short name:
    19 kDa FKBP
    Short name:
    FKBP-19
    FK506-binding protein 11
    Short name:
    FKBP-11
    Rotamase
    Gene namesi
    Name:Fkbp11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1913370. Fkbp11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: RefGenome
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 201174Peptidyl-prolyl cis-trans isomerase FKBP11PRO_0000025520Add
    BLAST

    Proteomic databases

    MaxQBiQ9D1M7.
    PaxDbiQ9D1M7.
    PRIDEiQ9D1M7.

    PTM databases

    PhosphoSiteiQ9D1M7.

    Expressioni

    Gene expression databases

    BgeeiQ9D1M7.
    CleanExiMM_FKBP11.
    GenevestigatoriQ9D1M7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D1M7.
    SMRiQ9D1M7. Positions 57-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 14488PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0545.
    GeneTreeiENSGT00530000062784.
    HOGENOMiHOG000154887.
    HOVERGENiHBG051623.
    InParanoidiQ9D1M7.
    KOiK09576.
    OMAiSRPKVSK.
    OrthoDBiEOG7V1FTB.
    PhylomeDBiQ9D1M7.
    TreeFamiTF105296.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D1M7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLSPLLLPL QLLLLLLFSG AVCRAEAGPE TESPVRTLQV ETLVQPPESC    50
    TESAAIGDTL HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL 100
    LDMCVGEKRR AVIPSHLAYG KRGYPPSIPA DAVVQYDVEL IALIRANYWQ 150
    KLLKSILPLV GIAMVPALLG LIGYHLYRKA SRPKVSKKKL KEEKRNKSKK 200
    K 201
    Length:201
    Mass (Da):22,137
    Last modified:June 1, 2001 - v1
    Checksum:i94D955C57264BD82
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531S → F in BAB31559. (PubMed:16141072)Curated
    Sequence conflicti198 – 1981S → R in BAB31559. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003331 mRNA. Translation: BAB22719.1.
    AK019132 mRNA. Translation: BAB31559.1.
    BC037596 mRNA. Translation: AAH37596.1.
    CCDSiCCDS27803.1.
    RefSeqiNP_077131.2. NM_024169.3.
    UniGeneiMm.30729.

    Genome annotation databases

    EnsembliENSMUST00000003445; ENSMUSP00000003445; ENSMUSG00000003355.
    GeneIDi66120.
    KEGGimmu:66120.
    UCSCiuc007xnm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003331 mRNA. Translation: BAB22719.1 .
    AK019132 mRNA. Translation: BAB31559.1 .
    BC037596 mRNA. Translation: AAH37596.1 .
    CCDSi CCDS27803.1.
    RefSeqi NP_077131.2. NM_024169.3.
    UniGenei Mm.30729.

    3D structure databases

    ProteinModelPortali Q9D1M7.
    SMRi Q9D1M7. Positions 57-145.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D1M7.

    Proteomic databases

    MaxQBi Q9D1M7.
    PaxDbi Q9D1M7.
    PRIDEi Q9D1M7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003445 ; ENSMUSP00000003445 ; ENSMUSG00000003355 .
    GeneIDi 66120.
    KEGGi mmu:66120.
    UCSCi uc007xnm.1. mouse.

    Organism-specific databases

    CTDi 51303.
    MGIi MGI:1913370. Fkbp11.

    Phylogenomic databases

    eggNOGi COG0545.
    GeneTreei ENSGT00530000062784.
    HOGENOMi HOG000154887.
    HOVERGENi HBG051623.
    InParanoidi Q9D1M7.
    KOi K09576.
    OMAi SRPKVSK.
    OrthoDBi EOG7V1FTB.
    PhylomeDBi Q9D1M7.
    TreeFami TF105296.

    Miscellaneous databases

    NextBioi 320690.
    PROi Q9D1M7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D1M7.
    CleanExi MM_FKBP11.
    Genevestigatori Q9D1M7.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiFKB11_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1M7
    Secondary accession number(s): Q9CRE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3