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Protein

Eukaryotic translation elongation factor 1 epsilon-1

Gene

Eef1e1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive modulator of ATM response to DNA damage.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • embryo development Source: UniProtKB
  • glutathione metabolic process Source: GO_Central
  • negative regulation of cell proliferation Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of cellular senescence Source: MGI
  • positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  • translation Source: UniProtKB-KW

Keywordsi

Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation elongation factor 1 epsilon-1
Alternative name(s):
Elongation factor p18
Multisynthase complex auxiliary component p18
Gene namesi
Name:Eef1e1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913393. Eef1e1.

Subcellular locationi

GO - Cellular componenti

  • aminoacyl-tRNA synthetase multienzyme complex Source: CAFA
  • cytoplasm Source: UniProtKB
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002211332 – 174Eukaryotic translation elongation factor 1 epsilon-1Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1M4.
MaxQBiQ9D1M4.
PaxDbiQ9D1M4.
PeptideAtlasiQ9D1M4.
PRIDEiQ9D1M4.

PTM databases

iPTMnetiQ9D1M4.
PhosphoSitePlusiQ9D1M4.

Expressioni

Inductioni

By DNA damaging agents, such as UV, adriamycin, actinomycin D and cisplatin.1 Publication

Gene expression databases

BgeeiENSMUSG00000001707.
GenevisibleiQ9D1M4. MM.

Interactioni

Subunit structurei

Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9D1M4. 1 interactor.
MINTiMINT-4126622.
STRINGi10090.ENSMUSP00000001757.

Structurei

3D structure databases

ProteinModelPortaliQ9D1M4.
SMRiQ9D1M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 173GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 56N-terminalBy similarityAdd BLAST55
Regioni57 – 63LinkerBy similarity7
Regioni64 – 152C-terminalBy similarityAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 169By similarityAdd BLAST17

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00390000003564.
HOGENOMiHOG000026786.
HOVERGENiHBG003019.
InParanoidiQ9D1M4.
KOiK15439.
OMAiDGHSSKD.
OrthoDBiEOG091G0VQB.
PhylomeDBiQ9D1M4.
TreeFamiTF326005.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAELRLL EKSLGLKPGN KYSAQGERQI PVLQTNNGPS LMGLSTIATH
60 70 80 90 100
LVKQASKEHL LGSTAEEKAM VQQWLEFRVT RVDGHSSKED TQTLLKDLNS
110 120 130 140 150
YLEDKVYLAG HNITLADILL YYGLHRFIVD LTVQEKEKYL NVSRWFCHIQ
160 170
HYPDIRQHLS SIVFIKNRLY ANSH
Length:174
Mass (Da):19,859
Last modified:June 1, 2001 - v1
Checksum:iAC804776D9C0590E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003335 mRNA. Translation: BAB22723.1.
BC048466 mRNA. Translation: AAH48466.1.
CCDSiCCDS26465.1.
RefSeqiNP_079656.1. NM_025380.2.
UniGeneiMm.490319.

Genome annotation databases

EnsembliENSMUST00000001757; ENSMUSP00000001757; ENSMUSG00000001707.
GeneIDi66143.
KEGGimmu:66143.
UCSCiuc007qdw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMCA3_MOUSE
AccessioniPrimary (citable) accession number: Q9D1M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot