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Q9D1K2

- VATF_MOUSE

UniProt

Q9D1K2 - VATF_MOUSE

Protein

V-type proton ATPase subunit F

Gene

Atp6v1f

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. proton-transporting ATPase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit F
    Short name:
    V-ATPase subunit F
    Alternative name(s):
    V-ATPase 14 kDa subunit
    Vacuolar proton pump subunit F
    Gene namesi
    Name:Atp6v1f
    Synonyms:Atp6s14, Vatf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1913394. Atp6v1f.

    Subcellular locationi

    GO - Cellular componenti

    1. proton-transporting V-type ATPase, V1 domain Source: InterPro
    2. vacuolar proton-transporting V-type ATPase complex Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119V-type proton ATPase subunit FPRO_0000144800Add
    BLAST

    Proteomic databases

    MaxQBiQ9D1K2.
    PaxDbiQ9D1K2.
    PRIDEiQ9D1K2.

    2D gel databases

    REPRODUCTION-2DPAGEQ9D1K2.

    PTM databases

    PhosphoSiteiQ9D1K2.

    Expressioni

    Gene expression databases

    BgeeiQ9D1K2.
    CleanExiMM_ATP6V1F.
    GenevestigatoriQ9D1K2.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

    Protein-protein interaction databases

    IntActiQ9D1K2. 4 interactions.
    MINTiMINT-4139820.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D1K2.
    SMRiQ9D1K2. Positions 7-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase F subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG1436.
    GeneTreeiENSGT00390000013208.
    HOGENOMiHOG000056545.
    HOVERGENiHBG004488.
    InParanoidiQ9D1K2.
    KOiK02151.
    OMAiRHVIDAH.
    OrthoDBiEOG7JMGGM.
    PhylomeDBiQ9D1K2.
    TreeFamiTF300080.

    Family and domain databases

    Gene3Di3.40.50.10580. 1 hit.
    InterProiIPR008218. ATPase_V1-cplx_f_g_su.
    IPR005772. ATPase_V1-cplx_fsu_euk.
    [Graphical view]
    PANTHERiPTHR13861. PTHR13861. 1 hit.
    PfamiPF01990. ATP-synt_F. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
    SUPFAMiSSF159468. SSF159468. 1 hit.
    TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9D1K2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED    50
    TFRQFLNRDD IGIILINQYI AEMVRHALDA HQRSIPAVLE IPSKEHPYDA 100
    AKDSILRRAK GMFTAEDLR 119
    Length:119
    Mass (Da):13,370
    Last modified:May 10, 2004 - v2
    Checksum:i9FFA95BD2667AA2A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351N → D in BAB22780. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003419 mRNA. Translation: BAB22780.1.
    AK007327 mRNA. Translation: BAB24962.1.
    AK152153 mRNA. Translation: BAE30988.1.
    AK152929 mRNA. Translation: BAE31604.1.
    AK152959 mRNA. Translation: BAE31622.1.
    BC016553 mRNA. Translation: AAH16553.1.
    CCDSiCCDS19960.1.
    RefSeqiNP_079657.1. NM_025381.2.
    UniGeneiMm.371614.

    Genome annotation databases

    EnsembliENSMUST00000004396; ENSMUSP00000004396; ENSMUSG00000004285.
    GeneIDi66144.
    KEGGimmu:66144.
    UCSCiuc009bdp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003419 mRNA. Translation: BAB22780.1 .
    AK007327 mRNA. Translation: BAB24962.1 .
    AK152153 mRNA. Translation: BAE30988.1 .
    AK152929 mRNA. Translation: BAE31604.1 .
    AK152959 mRNA. Translation: BAE31622.1 .
    BC016553 mRNA. Translation: AAH16553.1 .
    CCDSi CCDS19960.1.
    RefSeqi NP_079657.1. NM_025381.2.
    UniGenei Mm.371614.

    3D structure databases

    ProteinModelPortali Q9D1K2.
    SMRi Q9D1K2. Positions 7-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D1K2. 4 interactions.
    MINTi MINT-4139820.

    Protein family/group databases

    TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei Q9D1K2.

    2D gel databases

    REPRODUCTION-2DPAGE Q9D1K2.

    Proteomic databases

    MaxQBi Q9D1K2.
    PaxDbi Q9D1K2.
    PRIDEi Q9D1K2.

    Protocols and materials databases

    DNASUi 66144.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004396 ; ENSMUSP00000004396 ; ENSMUSG00000004285 .
    GeneIDi 66144.
    KEGGi mmu:66144.
    UCSCi uc009bdp.1. mouse.

    Organism-specific databases

    CTDi 9296.
    MGIi MGI:1913394. Atp6v1f.

    Phylogenomic databases

    eggNOGi COG1436.
    GeneTreei ENSGT00390000013208.
    HOGENOMi HOG000056545.
    HOVERGENi HBG004488.
    InParanoidi Q9D1K2.
    KOi K02151.
    OMAi RHVIDAH.
    OrthoDBi EOG7JMGGM.
    PhylomeDBi Q9D1K2.
    TreeFami TF300080.

    Enzyme and pathway databases

    Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi ATP6V1F. mouse.
    NextBioi 320762.
    PROi Q9D1K2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D1K2.
    CleanExi MM_ATP6V1F.
    Genevestigatori Q9D1K2.

    Family and domain databases

    Gene3Di 3.40.50.10580. 1 hit.
    InterProi IPR008218. ATPase_V1-cplx_f_g_su.
    IPR005772. ATPase_V1-cplx_fsu_euk.
    [Graphical view ]
    PANTHERi PTHR13861. PTHR13861. 1 hit.
    Pfami PF01990. ATP-synt_F. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015945. ATPase_V1_F_euk. 1 hit.
    SUPFAMi SSF159468. SSF159468. 1 hit.
    TIGRFAMsi TIGR01101. V_ATP_synt_F. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Embryo and Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary tumor.
    3. Lubec G., Klug S.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 42-53, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiVATF_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1K2
    Secondary accession number(s): Q3U6X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3