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Q9D1J3

- SARNP_MOUSE

UniProt

Q9D1J3 - SARNP_MOUSE

Protein

SAP domain-containing ribonucleoprotein

Gene

Sarnp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA export from nucleus Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. regulation of translation Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Transcription, Transcription regulation, Translation regulation, Transport

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SAP domain-containing ribonucleoprotein
    Alternative name(s):
    Nuclear protein Hcc-1
    Gene namesi
    Name:Sarnp
    Synonyms:Hcc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1913368. Sarnp.

    Subcellular locationi

    Nucleus By similarity. Nucleus speckle By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB
    2. transcription export complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 210209SAP domain-containing ribonucleoproteinPRO_0000083919Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei10 – 101N6-acetyllysine1 Publication
    Modified residuei142 – 1421N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9D1J3.
    PaxDbiQ9D1J3.
    PRIDEiQ9D1J3.

    PTM databases

    PhosphoSiteiQ9D1J3.

    Expressioni

    Gene expression databases

    BgeeiQ9D1J3.
    CleanExiMM_1110005A23RIK.
    GenevestigatoriQ9D1J3.

    Interactioni

    Subunit structurei

    Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9D1J3. 1 interaction.
    MINTiMINT-1867986.
    STRINGi10090.ENSMUSP00000100863.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D1J3.
    SMRiQ9D1J3. Positions 6-47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 4235SAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG290157.
    GeneTreeiENSGT00390000002944.
    HOGENOMiHOG000013054.
    InParanoidiQ9D1J3.
    OMAiSDAKPMV.
    OrthoDBiEOG7J9VRJ.
    PhylomeDBiQ9D1J3.
    TreeFamiTF319843.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    InterProiIPR003034. SAP_dom.
    [Graphical view]
    PfamiPF02037. SAP. 1 hit.
    [Graphical view]
    SMARTiSM00513. SAP. 1 hit.
    [Graphical view]
    PROSITEiPS50800. SAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D1J3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAETVELHK LKLAELKQEC LARGLETKGI KQDLINRLQA YLEDHAEEEA    50
    NEEDVLGDET EEEEPKPIEL PVKEEEPPEK AVDMASEKKV VKITSGIPQT 100
    ERMQKRAERF NVPVSLESKK AARAARFGIS SVPTKGLSSD TKPMVNLDKL 150
    KERAQRFGLN VSSISRKSED DEKLKKRKER FGIVTSSAGT GTTEDTEAKK 200
    RKRAERFGIA 210
    Length:210
    Mass (Da):23,533
    Last modified:January 23, 2007 - v3
    Checksum:i15705691F989E9AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003453 mRNA. Translation: BAB22799.1.
    AK018773 mRNA. Translation: BAB31400.1.
    AK088266 mRNA. Translation: BAC40246.1.
    AK146248 mRNA. Translation: BAE27010.1.
    BC027510 mRNA. Translation: AAH27510.1.
    CCDSiCCDS36092.1.
    RefSeqiNP_079640.1. NM_025364.2.
    UniGeneiMm.351579.

    Genome annotation databases

    EnsembliENSMUST00000056396; ENSMUSP00000137244; ENSMUSG00000051255.
    ENSMUST00000105230; ENSMUSP00000100863; ENSMUSG00000078427.
    GeneIDi66118.
    KEGGimmu:66118.
    UCSCiuc007hor.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003453 mRNA. Translation: BAB22799.1 .
    AK018773 mRNA. Translation: BAB31400.1 .
    AK088266 mRNA. Translation: BAC40246.1 .
    AK146248 mRNA. Translation: BAE27010.1 .
    BC027510 mRNA. Translation: AAH27510.1 .
    CCDSi CCDS36092.1.
    RefSeqi NP_079640.1. NM_025364.2.
    UniGenei Mm.351579.

    3D structure databases

    ProteinModelPortali Q9D1J3.
    SMRi Q9D1J3. Positions 6-47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D1J3. 1 interaction.
    MINTi MINT-1867986.
    STRINGi 10090.ENSMUSP00000100863.

    PTM databases

    PhosphoSitei Q9D1J3.

    Proteomic databases

    MaxQBi Q9D1J3.
    PaxDbi Q9D1J3.
    PRIDEi Q9D1J3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056396 ; ENSMUSP00000137244 ; ENSMUSG00000051255 .
    ENSMUST00000105230 ; ENSMUSP00000100863 ; ENSMUSG00000078427 .
    GeneIDi 66118.
    KEGGi mmu:66118.
    UCSCi uc007hor.2. mouse.

    Organism-specific databases

    CTDi 84324.
    MGIi MGI:1913368. Sarnp.

    Phylogenomic databases

    eggNOGi NOG290157.
    GeneTreei ENSGT00390000002944.
    HOGENOMi HOG000013054.
    InParanoidi Q9D1J3.
    OMAi SDAKPMV.
    OrthoDBi EOG7J9VRJ.
    PhylomeDBi Q9D1J3.
    TreeFami TF319843.

    Miscellaneous databases

    NextBioi 320682.
    PROi Q9D1J3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D1J3.
    CleanExi MM_1110005A23RIK.
    Genevestigatori Q9D1J3.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    InterProi IPR003034. SAP_dom.
    [Graphical view ]
    Pfami PF02037. SAP. 1 hit.
    [Graphical view ]
    SMARTi SM00513. SAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BALB/c, C57BL/6J and NOD.
      Tissue: Cerebellum, Embryo and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2; LYS-10 AND LYS-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSARNP_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1J3
    Secondary accession number(s): Q3UJZ4, Q9CU18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3