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Protein

SAP domain-containing ribonucleoprotein

Gene

Sarnp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • protein C-terminus binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  • RS domain binding Source: MGI
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transcription, Transcription regulation, Translation regulation, Transport

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
SAP domain-containing ribonucleoprotein
Alternative name(s):
Nuclear protein Hcc-1
Gene namesi
Name:Sarnp
Synonyms:Hcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 10, Chromosome 19

Organism-specific databases

MGIiMGI:1913368. Sarnp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000839192 – 210SAP domain-containing ribonucleoproteinAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10N6-acetyllysineCombined sources1
Modified residuei142N6-acetyllysineCombined sources1
Modified residuei163PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D1J3.
MaxQBiQ9D1J3.
PaxDbiQ9D1J3.
PRIDEiQ9D1J3.

PTM databases

iPTMnetiQ9D1J3.
PhosphoSitePlusiQ9D1J3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051255.
CleanExiMM_1110005A23RIK.
ExpressionAtlasiQ9D1J3. baseline and differential.
GenevisibleiQ9D1J3. MM.

Interactioni

Subunit structurei

Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4 (By similarity).By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: MGI
  • RS domain binding Source: MGI

Protein-protein interaction databases

BioGridi211227. 1 interactor.
IntActiQ9D1J3. 1 interactor.
MINTiMINT-1867986.
STRINGi10090.ENSMUSP00000137244.

Structurei

3D structure databases

ProteinModelPortaliQ9D1J3.
SMRiQ9D1J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 42SAPPROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4259. Eukaryota.
ENOG4111IA4. LUCA.
GeneTreeiENSGT00390000002944.
HOGENOMiHOG000013054.
InParanoidiQ9D1J3.
KOiK18732.
OMAiKPMVNMD.
OrthoDBiEOG091G1BB1.
PhylomeDBiQ9D1J3.
TreeFamiTF319843.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAETVELHK LKLAELKQEC LARGLETKGI KQDLINRLQA YLEDHAEEEA
60 70 80 90 100
NEEDVLGDET EEEEPKPIEL PVKEEEPPEK AVDMASEKKV VKITSGIPQT
110 120 130 140 150
ERMQKRAERF NVPVSLESKK AARAARFGIS SVPTKGLSSD TKPMVNLDKL
160 170 180 190 200
KERAQRFGLN VSSISRKSED DEKLKKRKER FGIVTSSAGT GTTEDTEAKK
210
RKRAERFGIA
Length:210
Mass (Da):23,533
Last modified:January 23, 2007 - v3
Checksum:i15705691F989E9AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003453 mRNA. Translation: BAB22799.1.
AK018773 mRNA. Translation: BAB31400.1.
AK088266 mRNA. Translation: BAC40246.1.
AK146248 mRNA. Translation: BAE27010.1.
BC027510 mRNA. Translation: AAH27510.1.
CCDSiCCDS36092.1.
RefSeqiNP_079640.1. NM_025364.2.
UniGeneiMm.235562.
Mm.351579.

Genome annotation databases

EnsembliENSMUST00000056396; ENSMUSP00000137244; ENSMUSG00000051255.
ENSMUST00000105230; ENSMUSP00000100863; ENSMUSG00000078427.
GeneIDi66118.
KEGGimmu:66118.
UCSCiuc007hor.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003453 mRNA. Translation: BAB22799.1.
AK018773 mRNA. Translation: BAB31400.1.
AK088266 mRNA. Translation: BAC40246.1.
AK146248 mRNA. Translation: BAE27010.1.
BC027510 mRNA. Translation: AAH27510.1.
CCDSiCCDS36092.1.
RefSeqiNP_079640.1. NM_025364.2.
UniGeneiMm.235562.
Mm.351579.

3D structure databases

ProteinModelPortaliQ9D1J3.
SMRiQ9D1J3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211227. 1 interactor.
IntActiQ9D1J3. 1 interactor.
MINTiMINT-1867986.
STRINGi10090.ENSMUSP00000137244.

PTM databases

iPTMnetiQ9D1J3.
PhosphoSitePlusiQ9D1J3.

Proteomic databases

EPDiQ9D1J3.
MaxQBiQ9D1J3.
PaxDbiQ9D1J3.
PRIDEiQ9D1J3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056396; ENSMUSP00000137244; ENSMUSG00000051255.
ENSMUST00000105230; ENSMUSP00000100863; ENSMUSG00000078427.
GeneIDi66118.
KEGGimmu:66118.
UCSCiuc007hor.2. mouse.

Organism-specific databases

CTDi84324.
MGIiMGI:1913368. Sarnp.

Phylogenomic databases

eggNOGiKOG4259. Eukaryota.
ENOG4111IA4. LUCA.
GeneTreeiENSGT00390000002944.
HOGENOMiHOG000013054.
InParanoidiQ9D1J3.
KOiK18732.
OMAiKPMVNMD.
OrthoDBiEOG091G1BB1.
PhylomeDBiQ9D1J3.
TreeFamiTF319843.

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72187. mRNA 3'-end processing.

Miscellaneous databases

PROiQ9D1J3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051255.
CleanExiMM_1110005A23RIK.
ExpressionAtlasiQ9D1J3. baseline and differential.
GenevisibleiQ9D1J3. MM.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSARNP_MOUSE
AccessioniPrimary (citable) accession number: Q9D1J3
Secondary accession number(s): Q3UJZ4, Q9CU18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.