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Protein

39S ribosomal protein L14, mitochondrial

Gene

Mrpl14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L14, mitochondrial
Short name:
L14mt
Short name:
MRP-L14
Gene namesi
Name:Mrpl14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1333864. Mrpl14.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000026113531 – 14539S ribosomal protein L14, mitochondrialAdd BLAST115

Proteomic databases

EPDiQ9D1I6.
MaxQBiQ9D1I6.
PaxDbiQ9D1I6.
PeptideAtlasiQ9D1I6.
PRIDEiQ9D1I6.

PTM databases

PhosphoSitePlusiQ9D1I6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023939.
CleanExiMM_MRPL14.
GenevisibleiQ9D1I6. MM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with MALSU1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024734.

Structurei

3D structure databases

ProteinModelPortaliQ9D1I6.
SMRiQ9D1I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L14P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3441. Eukaryota.
ENOG4111JDP. LUCA.
GeneTreeiENSGT00390000001121.
HOGENOMiHOG000183701.
HOVERGENiHBG088508.
InParanoidiQ9D1I6.
KOiK02874.
OMAiHRMPGPR.
OrthoDBiEOG091G1144.
PhylomeDBiQ9D1I6.
TreeFamiTF324586.

Family and domain databases

Gene3Di2.40.150.20. 1 hit.
HAMAPiMF_01367. Ribosomal_L14. 1 hit.
InterProiIPR000218. Ribosomal_L14P.
[Graphical view]
PfamiPF00238. Ribosomal_L14. 1 hit.
[Graphical view]
SMARTiSM01374. Ribosomal_L14. 1 hit.
[Graphical view]
SUPFAMiSSF50193. SSF50193. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTGLWGS FAHVSRAFSQ RCFSTSGSLS AVQKMTRVRV VDNSALGSTP
60 70 80 90 100
YHRPPRCIHV YNKSGVGKVG DQILLAIRGQ KKKALIVGHR MPGSRMTPKF
110 120 130 140
DSNNVVLIED NGNPVGTRIK IPIPTSLRRR EGEYSKVLAI AQNFV
Length:145
Mass (Da):15,874
Last modified:June 1, 2001 - v1
Checksum:i90D049E030897A93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 34VQK → IQ in BAE25734 (PubMed:16141072).Curated3
Sequence conflicti104N → S in BAE25734 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003500 mRNA. Translation: BAB22824.1.
AK050273 mRNA. Translation: BAC34158.1.
AK144153 mRNA. Translation: BAE25734.1.
BC027021 mRNA. Translation: AAH27021.1.
CCDSiCCDS28815.1.
RefSeqiNP_081008.1. NM_026732.2.
XP_006524906.1. XM_006524843.2.
XP_006524907.1. XM_006524844.3.
UniGeneiMm.379158.

Genome annotation databases

EnsembliENSMUST00000024734; ENSMUSP00000024734; ENSMUSG00000023939.
GeneIDi68463.
KEGGimmu:68463.
UCSCiuc008crj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003500 mRNA. Translation: BAB22824.1.
AK050273 mRNA. Translation: BAC34158.1.
AK144153 mRNA. Translation: BAE25734.1.
BC027021 mRNA. Translation: AAH27021.1.
CCDSiCCDS28815.1.
RefSeqiNP_081008.1. NM_026732.2.
XP_006524906.1. XM_006524843.2.
XP_006524907.1. XM_006524844.3.
UniGeneiMm.379158.

3D structure databases

ProteinModelPortaliQ9D1I6.
SMRiQ9D1I6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024734.

PTM databases

PhosphoSitePlusiQ9D1I6.

Proteomic databases

EPDiQ9D1I6.
MaxQBiQ9D1I6.
PaxDbiQ9D1I6.
PeptideAtlasiQ9D1I6.
PRIDEiQ9D1I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024734; ENSMUSP00000024734; ENSMUSG00000023939.
GeneIDi68463.
KEGGimmu:68463.
UCSCiuc008crj.1. mouse.

Organism-specific databases

CTDi64928.
MGIiMGI:1333864. Mrpl14.

Phylogenomic databases

eggNOGiKOG3441. Eukaryota.
ENOG4111JDP. LUCA.
GeneTreeiENSGT00390000001121.
HOGENOMiHOG000183701.
HOVERGENiHBG088508.
InParanoidiQ9D1I6.
KOiK02874.
OMAiHRMPGPR.
OrthoDBiEOG091G1144.
PhylomeDBiQ9D1I6.
TreeFamiTF324586.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ9D1I6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023939.
CleanExiMM_MRPL14.
GenevisibleiQ9D1I6. MM.

Family and domain databases

Gene3Di2.40.150.20. 1 hit.
HAMAPiMF_01367. Ribosomal_L14. 1 hit.
InterProiIPR000218. Ribosomal_L14P.
[Graphical view]
PfamiPF00238. Ribosomal_L14. 1 hit.
[Graphical view]
SMARTiSM01374. Ribosomal_L14. 1 hit.
[Graphical view]
SUPFAMiSSF50193. SSF50193. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM14_MOUSE
AccessioniPrimary (citable) accession number: Q9D1I6
Secondary accession number(s): Q3UNL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.