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Protein

39S ribosomal protein L14, mitochondrial

Gene

Mrpl14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L14, mitochondrial
Short name:
L14mt
Short name:
MRP-L14
Gene namesi
Name:Mrpl14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1333864 Mrpl14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000026113531 – 14539S ribosomal protein L14, mitochondrialAdd BLAST115

Proteomic databases

EPDiQ9D1I6
MaxQBiQ9D1I6
PaxDbiQ9D1I6
PeptideAtlasiQ9D1I6
PRIDEiQ9D1I6

PTM databases

PhosphoSitePlusiQ9D1I6

Expressioni

Gene expression databases

BgeeiENSMUSG00000023939
CleanExiMM_MRPL14
GenevisibleiQ9D1I6 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with MALSU1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024734

Structurei

3D structure databases

ProteinModelPortaliQ9D1I6
SMRiQ9D1I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3441 Eukaryota
ENOG4111JDP LUCA
GeneTreeiENSGT00390000001121
HOGENOMiHOG000183701
HOVERGENiHBG088508
InParanoidiQ9D1I6
KOiK02874
OMAiHRMPGPR
OrthoDBiEOG091G1144
PhylomeDBiQ9D1I6
TreeFamiTF324586

Family and domain databases

Gene3Di2.40.150.20, 1 hit
HAMAPiMF_01367 Ribosomal_L14, 1 hit
InterProiView protein in InterPro
IPR036853 Ribosomal_L14_sf
IPR000218 Ribosomal_L14P
PfamiView protein in Pfam
PF00238 Ribosomal_L14, 1 hit
SMARTiView protein in SMART
SM01374 Ribosomal_L14, 1 hit
SUPFAMiSSF50193 SSF50193, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTGLWGS FAHVSRAFSQ RCFSTSGSLS AVQKMTRVRV VDNSALGSTP
60 70 80 90 100
YHRPPRCIHV YNKSGVGKVG DQILLAIRGQ KKKALIVGHR MPGSRMTPKF
110 120 130 140
DSNNVVLIED NGNPVGTRIK IPIPTSLRRR EGEYSKVLAI AQNFV
Length:145
Mass (Da):15,874
Last modified:June 1, 2001 - v1
Checksum:i90D049E030897A93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 34VQK → IQ in BAE25734 (PubMed:16141072).Curated3
Sequence conflicti104N → S in BAE25734 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003500 mRNA Translation: BAB22824.1
AK050273 mRNA Translation: BAC34158.1
AK144153 mRNA Translation: BAE25734.1
BC027021 mRNA Translation: AAH27021.1
CCDSiCCDS28815.1
RefSeqiNP_081008.1, NM_026732.2
XP_006524906.1, XM_006524843.2
XP_006524907.1, XM_006524844.3
UniGeneiMm.379158

Genome annotation databases

EnsembliENSMUST00000024734; ENSMUSP00000024734; ENSMUSG00000023939
GeneIDi68463
KEGGimmu:68463
UCSCiuc008crj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRM14_MOUSE
AccessioniPrimary (citable) accession number: Q9D1I6
Secondary accession number(s): Q3UNL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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