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Protein

Methylmalonyl-CoA epimerase, mitochondrial

Gene

Mcee

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Cobalt; via tele nitrogenBy similarity1
Metal bindingi124Cobalt; via tele nitrogenBy similarity1
Metal bindingi174CobaltBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandCobalt, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71032. Propionyl-CoA catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonyl-CoA epimerase, mitochondrial (EC:5.1.99.1)
Alternative name(s):
DL-methylmalonyl-CoA racemase
Gene namesi
Name:Mcee
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920974. Mcee.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
ChainiPRO_000001228439 – 178Methylmalonyl-CoA epimerase, mitochondrialAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-succinyllysineCombined sources1
Modified residuei152N6-acetyllysine; alternateCombined sources1
Modified residuei152N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1I5.
MaxQBiQ9D1I5.
PaxDbiQ9D1I5.
PeptideAtlasiQ9D1I5.
PRIDEiQ9D1I5.

PTM databases

iPTMnetiQ9D1I5.
PhosphoSitePlusiQ9D1I5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033429.
CleanExiMM_MCEE.
ExpressionAtlasiQ9D1I5. baseline and differential.
GenevisibleiQ9D1I5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D1I5. 1 interactor.
MINTiMINT-1860107.
STRINGi10090.ENSMUSP00000047855.

Structurei

3D structure databases

ProteinModelPortaliQ9D1I5.
SMRiQ9D1I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 178VOCPROSITE-ProRule annotationAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 143Poly-Lys4

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2944. Eukaryota.
COG0346. LUCA.
GeneTreeiENSGT00390000004772.
HOGENOMiHOG000232024.
HOVERGENiHBG052426.
InParanoidiQ9D1I5.
KOiK05606.
OMAiCYEVDDI.
OrthoDBiEOG091G0WSQ.
PhylomeDBiQ9D1I5.
TreeFamiTF313417.

Family and domain databases

CDDicd07249. MMCE. 1 hit.
Gene3Di3.10.180.10. 1 hit.
InterProiView protein in InterPro
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR017515. MeMalonyl-CoA_epimerase.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR03081. metmalonyl_epim. 1 hit.
PROSITEiView protein in PROSITE
PS51819. VOC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVVKAAAL AAGATGLFSR VQTSVAIGRS FSTPQSQFQE SSPVWKLGRL
60 70 80 90 100
NHVAVAVPDL EKASSFYRDV LGAQVSEVVP LPEHGVSVVF VNLGNTKMEL
110 120 130 140 150
LHPLGSDSPI TGFLQKNKAG GMHHVCIEVD NISAAVMDLK KKKIRSLSDE
160 170
AKIGAHGKPV IFLHPKDCGG VLVELEQA
Length:178
Mass (Da):19,017
Last modified:June 1, 2001 - v1
Checksum:i0A496AF10455D379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003511 mRNA. Translation: BAB22828.1.
BC038157 mRNA. Translation: AAH38157.1.
CCDSiCCDS21334.1.
RefSeqiNP_082902.1. NM_028626.1.
UniGeneiMm.10093.

Genome annotation databases

EnsembliENSMUST00000037205; ENSMUSP00000047855; ENSMUSG00000033429.
GeneIDi73724.
KEGGimmu:73724.
UCSCiuc009hgi.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMCEE_MOUSE
AccessioniPrimary (citable) accession number: Q9D1I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families