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Protein

Caspase recruitment domain-containing protein 19

Gene

Card19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 19Imported
Alternative name(s):
Bcl10-interacting CARD proteinBy similarity
Short name:
BinCARDBy similarity
Gene namesi
Name:Card19Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915730. Card19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Caspase recruitment domain-containing protein 19PRO_0000064928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 ↔ 77Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9D1I2.
MaxQBiQ9D1I2.
PaxDbiQ9D1I2.
PRIDEiQ9D1I2.

PTM databases

PhosphoSiteiQ9D1I2.

Expressioni

Gene expression databases

BgeeiQ9D1I2.
CleanExiMM_1110007C09RIK.
ExpressionAtlasiQ9D1I2. baseline and differential.
GenevisibleiQ9D1I2. MM.

Interactioni

Subunit structurei

Associates with BCL10 by CARD-CARD interaction.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047569.

Structurei

3D structure databases

ProteinModelPortaliQ9D1I2.
SMRiQ9D1I2. Positions 3-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 9992CARDAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKT7. Eukaryota.
ENOG4111ZB0. LUCA.
GeneTreeiENSGT00390000016408.
HOGENOMiHOG000095230.
HOVERGENiHBG080896.
InParanoidiQ9D1I2.
OMAiCCPPDPK.
OrthoDBiEOG7KM5V8.
PhylomeDBiQ9D1I2.
TreeFamiTF335747.

Family and domain databases

InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D1I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQTYCDRL VQDTPFLTGQ GRLSEQQVDR IILQLNRYYP QILTNKEAEK
60 70 80 90 100
FRNPKASLRV RLCDLLSHLQ QRGERHCQEF YRALYIHAQP LHSHLPSRYS
110 120 130 140 150
PQNSDCRELD WGIESRELSD RGPMSFLAGL GLAAGLALLL YCCPPDPKVL
160 170 180
PGTRRVLAFS PVIIDRHVSR YLLAFLADDL GGL
Length:183
Mass (Da):20,936
Last modified:June 1, 2001 - v1
Checksum:i3A78FE6F81D2E33E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003526 mRNA. Translation: BAB22838.1.
AK154517 mRNA. Translation: BAE32646.1.
CCDSiCCDS49260.1.
RefSeqiNP_081014.1. NM_026738.2.
UniGeneiMm.3336.

Genome annotation databases

EnsembliENSMUST00000048946; ENSMUSP00000047569; ENSMUSG00000037960.
GeneIDi68480.
KEGGimmu:68480.
UCSCiuc007qiy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003526 mRNA. Translation: BAB22838.1.
AK154517 mRNA. Translation: BAE32646.1.
CCDSiCCDS49260.1.
RefSeqiNP_081014.1. NM_026738.2.
UniGeneiMm.3336.

3D structure databases

ProteinModelPortaliQ9D1I2.
SMRiQ9D1I2. Positions 3-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047569.

PTM databases

PhosphoSiteiQ9D1I2.

Proteomic databases

EPDiQ9D1I2.
MaxQBiQ9D1I2.
PaxDbiQ9D1I2.
PRIDEiQ9D1I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048946; ENSMUSP00000047569; ENSMUSG00000037960.
GeneIDi68480.
KEGGimmu:68480.
UCSCiuc007qiy.1. mouse.

Organism-specific databases

CTDi84270.
MGIiMGI:1915730. Card19.

Phylogenomic databases

eggNOGiENOG410IKT7. Eukaryota.
ENOG4111ZB0. LUCA.
GeneTreeiENSGT00390000016408.
HOGENOMiHOG000095230.
HOVERGENiHBG080896.
InParanoidiQ9D1I2.
OMAiCCPPDPK.
OrthoDBiEOG7KM5V8.
PhylomeDBiQ9D1I2.
TreeFamiTF335747.

Miscellaneous databases

PROiQ9D1I2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D1I2.
CleanExiMM_1110007C09RIK.
ExpressionAtlasiQ9D1I2. baseline and differential.
GenevisibleiQ9D1I2. MM.

Family and domain databases

InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney and Lung.

Entry informationi

Entry nameiCAR19_MOUSE
AccessioniPrimary (citable) accession number: Q9D1I2
Secondary accession number(s): Q3U3Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.