Reviewed, UniProtKB/Swiss-Prot Q9D1I2 (BINCA_MOUSE)

Names and origin

Protein names	Recommended name:     Bcl10-interacting CARD protein       Short name=BinCARD
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B By similarity.
Subunit structure	Associates with BCL10 by CARD-CARD interaction By similarity.
Subcellular location	Nucleus By similarity. Note: Co-expression with BCL10 induced translocation from nucleus to cytosol By similarity.
Sequence similarities	Contains 1 CARD domain.

Ontologies

Keywords
Cellular component	Nucleus
Gene Ontology (GO)
Biological process	regulation of apoptosis Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Bcl10-interacting CARD protein		PRO_0000064928
Regions
	Domain	8 – 99	92	CARD

Sequences

	Sequence		Length	Mass (Da)
	Q9D1I2-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 3A78FE6F81D2E33E	FASTA	183	20,936
	10 20 30 40 50 60 MTDQTYCDRL VQDTPFLTGQ GRLSEQQVDR IILQLNRYYP QILTNKEAEK FRNPKASLRV 70 80 90 100 110 120 RLCDLLSHLQ QRGERHCQEF YRALYIHAQP LHSHLPSRYS PQNSDCRELD WGIESRELSD 130 140 150 160 170 180 RGPMSFLAGL GLAAGLALLL YCCPPDPKVL PGTRRVLAFS PVIIDRHVSR YLLAFLADDL GGL

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK003526 mRNA. Translation: BAB22838.1. AK154517 mRNA. Translation: BAE32646.1.
IPI	IPI00315974.
RefSeq	NP_081014.1.
UniGene	Mm.3336
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9D1I2.
Proteomic databases
PRIDE	Q9D1I2.
Genome annotation databases
Ensembl	ENSMUST00000048946; ENSMUSP00000047569; ENSMUSG00000037960; Mus musculus. [Genome view]
GeneID	68480.
KEGG	mmu:68480.
UCSC	uc007qiy.1. mouse.
Organism-specific databases
MGI	MGI:1915730. 1110007C09Rik.
Phylogenomic databases
HOGENOM	Q9D1I2.
HOVERGEN	Q9D1I2.
Gene expression databases
ArrayExpress	Q9D1I2.
Bgee	Q9D1I2.
CleanEx	MM_1110007C09RIK.
Genevestigator	Q9D1I2.
GermOnline	ENSMUSG00000037960. Mus musculus.
Family and domain databases
InterPro	IPR001315. CARD. [Graphical view]
Pfam	PF00619. CARD. 1 hit. [Graphical view]
PROSITE	PS50209. CARD. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	327258.

Entry information

Entry name

BINCA_MOUSE

Accession

Primary (citable) accession number: Q9D1I2
Secondary accession number(s): Q3U3Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	June 1, 2001
Last modified:	October 13, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)