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Protein

Microfibril-associated glycoprotein 4

Gene

Mfap4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance.By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibril-associated glycoprotein 4
Gene namesi
Name:Mfap4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1342276 Mfap4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000913523 – 257Microfibril-associated glycoprotein 4Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D1H9
PeptideAtlasiQ9D1H9
PRIDEiQ9D1H9

PTM databases

iPTMnetiQ9D1H9
PhosphoSitePlusiQ9D1H9

Expressioni

Gene expression databases

BgeeiENSMUSG00000042436
CleanExiMM_MFAP4
GenevisibleiQ9D1H9 MM

Interactioni

Subunit structurei

Homodimer. Can also form higher oligomers. Interacts with FBN1, FBN2 and LOX. Interacts with COL1A1 in a Ca (2+)-dependent manner. Interacts with ELN in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly.By similarity

Protein-protein interaction databases

IntActiQ9D1H9, 1 interactor
MINTiQ9D1H9
STRINGi10090.ENSMUSP00000070848

Structurei

3D structure databases

ProteinModelPortaliQ9D1H9
SMRiQ9D1H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 257Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST224

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 30Cell attachment siteSequence analysis3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00830000128240
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiQ9D1H9
OMAiSGAFWFR
OrthoDBiEOG091G03M1
PhylomeDBiQ9D1H9
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D1H9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKALPALPLM LMLLSMPPPC APQASGIRGD ALEKSCLQQP LDCDDIYAQG
60 70 80 90 100
YQEDGVYLIY PYGPSVPVPV FCDMTTEGGK WTVFQKRFNG SVSFFRGWSD
110 120 130 140 150
YKLGFGRADG EYWLGLQNLH LLTLKQKYEL RVDLEDFENN TAYAKYIDFS
160 170 180 190 200
ISPNAISAEE DGYTLYVAGF EDGGAGDSLS YHSGQKFSTF DRDQDLFVQN
210 220 230 240 250
CAALSSGAFW FRSCHFANLN GFYLGGSHLS YANGINWAQW KGFYYSLKRT

EMKIRRA
Length:257
Mass (Da):28,938
Last modified:June 1, 2001 - v1
Checksum:iA1E80B9671399766
GO
Isoform 2 (identifier: Q9D1H9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-115: G → GKVGPWGGGCPSAKSLLTGCHPSLG

Note: Gene prediction confirmed by EST data.
Show »
Length:281
Mass (Da):31,229
Checksum:i2347D6F27839181F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013482115G → GKVGPWGGGCPSAKSLLTGC HPSLG in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003537 mRNA Translation: BAB22844.1
AL604029 Genomic DNA No translation available.
BC022666 mRNA Translation: AAH22666.1
CCDSiCCDS24813.1 [Q9D1H9-1]
CCDS83820.1 [Q9D1H9-2]
RefSeqiNP_001334474.1, NM_001347545.1 [Q9D1H9-2]
NP_083844.1, NM_029568.2 [Q9D1H9-1]
UniGeneiMm.272278

Genome annotation databases

EnsembliENSMUST00000040522; ENSMUSP00000038971; ENSMUSG00000042436 [Q9D1H9-2]
ENSMUST00000064783; ENSMUSP00000070848; ENSMUSG00000042436 [Q9D1H9-1]
GeneIDi76293
KEGGimmu:76293
UCSCiuc007jhm.1 mouse [Q9D1H9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMFAP4_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H9
Secondary accession number(s): Q5NCN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health