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Protein

Golgi to ER traffic protein 4 homolog

Gene

Get4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi to ER traffic protein 4 homolog
Gene namesi
Name:Get4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914854. Get4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002281052 – 327Golgi to ER traffic protein 4 homologAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1H7.
PaxDbiQ9D1H7.
PeptideAtlasiQ9D1H7.
PRIDEiQ9D1H7.

PTM databases

iPTMnetiQ9D1H7.
PhosphoSitePlusiQ9D1H7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025858.
CleanExiMM_1110007L15RIK.
ExpressionAtlasiQ9D1H7. baseline and differential.
GenevisibleiQ9D1H7. MM.

Interactioni

Subunit structurei

Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212305. 23 interactors.
IntActiQ9D1H7. 23 interactors.
STRINGi10090.ENSMUSP00000026976.

Structurei

3D structure databases

ProteinModelPortaliQ9D1H7.
SMRiQ9D1H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GET4 family.Curated

Phylogenomic databases

eggNOGiKOG3024. Eukaryota.
ENOG410XRWE. LUCA.
GeneTreeiENSGT00390000015750.
HOGENOMiHOG000264232.
HOVERGENiHBG059877.
InParanoidiQ9D1H7.
OMAiEGQFYEA.
OrthoDBiEOG091G0DTD.
PhylomeDBiQ9D1H7.
TreeFamiTF315163.

Family and domain databases

InterProiIPR007317. UPF0363.
[Graphical view]
PANTHERiPTHR12875. PTHR12875. 1 hit.
PfamiPF04190. DUF410. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D1H7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAMAEQ EGARNGARNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF
60 70 80 90 100
FRYMSQSKHA EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVDV
110 120 130 140 150
ADELLENLAK VFSLMDPNSP ERVAFVSRAL KWSSGGSGKL GHPRLHQLLA
160 170 180 190 200
LTLWKEQNYC ESRYHFLHSS DGEGCANMLV EYSTARGFRS EVDMFVAQAV
210 220 230 240 250
LQFLCLKNKN SALVVFTTYT QKHPSIEDGP PFVQPLLNFI WFLLLAVDGG
260 270 280 290 300
KLAVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN
310 320
LLSSLMGSSE QEEGEESQDD SSPIELD
Note: No experimental confirmation available.
Length:327
Mass (Da):36,525
Last modified:July 5, 2004 - v2
Checksum:i04B8DCC8E75FB022
GO
Isoform 2 (identifier: Q9D1H7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):30,560
Checksum:i185B7840B12D0698
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0176531 – 53Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003551 mRNA. Translation: BAB22851.2.
BC019557 mRNA. Translation: AAH19557.1.
CCDSiCCDS19805.1. [Q9D1H7-1]
CCDS51682.1. [Q9D1H7-2]
RefSeqiNP_001156788.1. NM_001163316.1. [Q9D1H7-2]
NP_080545.2. NM_026269.2. [Q9D1H7-1]
UniGeneiMm.270137.

Genome annotation databases

EnsembliENSMUST00000026976; ENSMUSP00000026976; ENSMUSG00000025858. [Q9D1H7-1]
ENSMUST00000110878; ENSMUSP00000106502; ENSMUSG00000025858. [Q9D1H7-2]
GeneIDi67604.
KEGGimmu:67604.
UCSCiuc009agg.2. mouse. [Q9D1H7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003551 mRNA. Translation: BAB22851.2.
BC019557 mRNA. Translation: AAH19557.1.
CCDSiCCDS19805.1. [Q9D1H7-1]
CCDS51682.1. [Q9D1H7-2]
RefSeqiNP_001156788.1. NM_001163316.1. [Q9D1H7-2]
NP_080545.2. NM_026269.2. [Q9D1H7-1]
UniGeneiMm.270137.

3D structure databases

ProteinModelPortaliQ9D1H7.
SMRiQ9D1H7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212305. 23 interactors.
IntActiQ9D1H7. 23 interactors.
STRINGi10090.ENSMUSP00000026976.

PTM databases

iPTMnetiQ9D1H7.
PhosphoSitePlusiQ9D1H7.

Proteomic databases

EPDiQ9D1H7.
PaxDbiQ9D1H7.
PeptideAtlasiQ9D1H7.
PRIDEiQ9D1H7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026976; ENSMUSP00000026976; ENSMUSG00000025858. [Q9D1H7-1]
ENSMUST00000110878; ENSMUSP00000106502; ENSMUSG00000025858. [Q9D1H7-2]
GeneIDi67604.
KEGGimmu:67604.
UCSCiuc009agg.2. mouse. [Q9D1H7-1]

Organism-specific databases

CTDi51608.
MGIiMGI:1914854. Get4.

Phylogenomic databases

eggNOGiKOG3024. Eukaryota.
ENOG410XRWE. LUCA.
GeneTreeiENSGT00390000015750.
HOGENOMiHOG000264232.
HOVERGENiHBG059877.
InParanoidiQ9D1H7.
OMAiEGQFYEA.
OrthoDBiEOG091G0DTD.
PhylomeDBiQ9D1H7.
TreeFamiTF315163.

Miscellaneous databases

ChiTaRSiGet4. mouse.
PROiQ9D1H7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025858.
CleanExiMM_1110007L15RIK.
ExpressionAtlasiQ9D1H7. baseline and differential.
GenevisibleiQ9D1H7. MM.

Family and domain databases

InterProiIPR007317. UPF0363.
[Graphical view]
PANTHERiPTHR12875. PTHR12875. 1 hit.
PfamiPF04190. DUF410. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGET4_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H7
Secondary accession number(s): Q78J86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.