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Q9D1H7

- GET4_MOUSE

UniProt

Q9D1H7 - GET4_MOUSE

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Protein

Golgi to ER traffic protein 4 homolog

Gene

Get4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (By similarity).By similarity

GO - Biological processi

  1. tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi to ER traffic protein 4 homolog
Gene namesi
Name:Get4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1914854. Get4.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. BAT3 complex Source: UniProtKB
  2. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 327326Golgi to ER traffic protein 4 homologPRO_0000228105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D1H7.
PaxDbiQ9D1H7.
PRIDEiQ9D1H7.

PTM databases

PhosphoSiteiQ9D1H7.

Expressioni

Gene expression databases

BgeeiQ9D1H7.
CleanExiMM_1110007L15RIK.
ExpressionAtlasiQ9D1H7. baseline and differential.
GenevestigatoriQ9D1H7.

Interactioni

Subunit structurei

Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35.By similarity

Protein-protein interaction databases

BioGridi212305. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9D1H7.
SMRiQ9D1H7. Positions 16-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GET4 family.Curated

Phylogenomic databases

eggNOGiNOG252493.
GeneTreeiENSGT00390000015750.
HOGENOMiHOG000264232.
HOVERGENiHBG059877.
InParanoidiQ9D1H7.
OMAiLLNFISM.
OrthoDBiEOG7PZRZ1.
PhylomeDBiQ9D1H7.
TreeFamiTF315163.

Family and domain databases

InterProiIPR007317. UPF0363.
[Graphical view]
PANTHERiPTHR12875. PTHR12875. 1 hit.
PfamiPF04190. DUF410. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D1H7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAMAEQ EGARNGARNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF
60 70 80 90 100
FRYMSQSKHA EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVDV
110 120 130 140 150
ADELLENLAK VFSLMDPNSP ERVAFVSRAL KWSSGGSGKL GHPRLHQLLA
160 170 180 190 200
LTLWKEQNYC ESRYHFLHSS DGEGCANMLV EYSTARGFRS EVDMFVAQAV
210 220 230 240 250
LQFLCLKNKN SALVVFTTYT QKHPSIEDGP PFVQPLLNFI WFLLLAVDGG
260 270 280 290 300
KLAVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN
310 320
LLSSLMGSSE QEEGEESQDD SSPIELD

Note: No experimental confirmation available.

Length:327
Mass (Da):36,525
Last modified:July 5, 2004 - v2
Checksum:i04B8DCC8E75FB022
GO
Isoform 2 (identifier: Q9D1H7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-53: Missing.

Note: No experimental confirmation available.

Show »
Length:275
Mass (Da):30,691
Checksum:iFCAB666888DD31FD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 5352Missing in isoform 2. 1 PublicationVSP_017653Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003551 mRNA. Translation: BAB22851.2.
BC019557 mRNA. Translation: AAH19557.1.
CCDSiCCDS19805.1. [Q9D1H7-1]
RefSeqiNP_001156788.1. NM_001163316.1.
NP_080545.2. NM_026269.2. [Q9D1H7-1]
UniGeneiMm.270137.

Genome annotation databases

EnsembliENSMUST00000026976; ENSMUSP00000026976; ENSMUSG00000025858. [Q9D1H7-1]
ENSMUST00000110878; ENSMUSP00000106502; ENSMUSG00000025858.
GeneIDi67604.
KEGGimmu:67604.
UCSCiuc009agg.2. mouse. [Q9D1H7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003551 mRNA. Translation: BAB22851.2 .
BC019557 mRNA. Translation: AAH19557.1 .
CCDSi CCDS19805.1. [Q9D1H7-1 ]
RefSeqi NP_001156788.1. NM_001163316.1.
NP_080545.2. NM_026269.2. [Q9D1H7-1 ]
UniGenei Mm.270137.

3D structure databases

ProteinModelPortali Q9D1H7.
SMRi Q9D1H7. Positions 16-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212305. 1 interaction.

PTM databases

PhosphoSitei Q9D1H7.

Proteomic databases

MaxQBi Q9D1H7.
PaxDbi Q9D1H7.
PRIDEi Q9D1H7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026976 ; ENSMUSP00000026976 ; ENSMUSG00000025858 . [Q9D1H7-1 ]
ENSMUST00000110878 ; ENSMUSP00000106502 ; ENSMUSG00000025858 .
GeneIDi 67604.
KEGGi mmu:67604.
UCSCi uc009agg.2. mouse. [Q9D1H7-1 ]

Organism-specific databases

CTDi 51608.
MGIi MGI:1914854. Get4.

Phylogenomic databases

eggNOGi NOG252493.
GeneTreei ENSGT00390000015750.
HOGENOMi HOG000264232.
HOVERGENi HBG059877.
InParanoidi Q9D1H7.
OMAi LLNFISM.
OrthoDBi EOG7PZRZ1.
PhylomeDBi Q9D1H7.
TreeFami TF315163.

Miscellaneous databases

NextBioi 325021.
PROi Q9D1H7.
SOURCEi Search...

Gene expression databases

Bgeei Q9D1H7.
CleanExi MM_1110007L15RIK.
ExpressionAtlasi Q9D1H7. baseline and differential.
Genevestigatori Q9D1H7.

Family and domain databases

InterProi IPR007317. UPF0363.
[Graphical view ]
PANTHERi PTHR12875. PTHR12875. 1 hit.
Pfami PF04190. DUF410. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiGET4_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H7
Secondary accession number(s): Q78J86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3