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Q9D1H7

- GET4_MOUSE

UniProt

Q9D1H7 - GET4_MOUSE

Protein

Golgi to ER traffic protein 4 homolog

Gene

Get4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting By similarity.By similarity

    GO - Biological processi

    1. tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
    2. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi to ER traffic protein 4 homolog
    Gene namesi
    Name:Get4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1914854. Get4.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. BAT3 complex Source: UniProtKB
    2. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 327326Golgi to ER traffic protein 4 homologPRO_0000228105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9D1H7.
    PaxDbiQ9D1H7.
    PRIDEiQ9D1H7.

    PTM databases

    PhosphoSiteiQ9D1H7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D1H7.
    BgeeiQ9D1H7.
    CleanExiMM_1110007L15RIK.
    GenevestigatoriQ9D1H7.

    Interactioni

    Subunit structurei

    Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35.By similarity

    Protein-protein interaction databases

    BioGridi212305. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D1H7.
    SMRiQ9D1H7. Positions 16-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GET4 family.Curated

    Phylogenomic databases

    eggNOGiNOG252493.
    GeneTreeiENSGT00390000015750.
    HOGENOMiHOG000264232.
    HOVERGENiHBG059877.
    InParanoidiQ9D1H7.
    OMAiLLNFISM.
    OrthoDBiEOG7PZRZ1.
    PhylomeDBiQ9D1H7.
    TreeFamiTF315163.

    Family and domain databases

    InterProiIPR007317. UPF0363.
    [Graphical view]
    PANTHERiPTHR12875. PTHR12875. 1 hit.
    PfamiPF04190. DUF410. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D1H7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAAMAEQ EGARNGARNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF    50
    FRYMSQSKHA EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVDV 100
    ADELLENLAK VFSLMDPNSP ERVAFVSRAL KWSSGGSGKL GHPRLHQLLA 150
    LTLWKEQNYC ESRYHFLHSS DGEGCANMLV EYSTARGFRS EVDMFVAQAV 200
    LQFLCLKNKN SALVVFTTYT QKHPSIEDGP PFVQPLLNFI WFLLLAVDGG 250
    KLAVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN 300
    LLSSLMGSSE QEEGEESQDD SSPIELD 327

    Note: No experimental confirmation available.

    Length:327
    Mass (Da):36,525
    Last modified:July 5, 2004 - v2
    Checksum:i04B8DCC8E75FB022
    GO
    Isoform 2 (identifier: Q9D1H7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-53: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:275
    Mass (Da):30,691
    Checksum:iFCAB666888DD31FD
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 5352Missing in isoform 2. 1 PublicationVSP_017653Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003551 mRNA. Translation: BAB22851.2.
    BC019557 mRNA. Translation: AAH19557.1.
    CCDSiCCDS19805.1. [Q9D1H7-1]
    RefSeqiNP_001156788.1. NM_001163316.1.
    NP_080545.2. NM_026269.2. [Q9D1H7-1]
    UniGeneiMm.270137.

    Genome annotation databases

    EnsembliENSMUST00000026976; ENSMUSP00000026976; ENSMUSG00000025858. [Q9D1H7-1]
    ENSMUST00000110878; ENSMUSP00000106502; ENSMUSG00000025858.
    GeneIDi67604.
    KEGGimmu:67604.
    UCSCiuc009agg.2. mouse. [Q9D1H7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003551 mRNA. Translation: BAB22851.2 .
    BC019557 mRNA. Translation: AAH19557.1 .
    CCDSi CCDS19805.1. [Q9D1H7-1 ]
    RefSeqi NP_001156788.1. NM_001163316.1.
    NP_080545.2. NM_026269.2. [Q9D1H7-1 ]
    UniGenei Mm.270137.

    3D structure databases

    ProteinModelPortali Q9D1H7.
    SMRi Q9D1H7. Positions 16-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212305. 1 interaction.

    PTM databases

    PhosphoSitei Q9D1H7.

    Proteomic databases

    MaxQBi Q9D1H7.
    PaxDbi Q9D1H7.
    PRIDEi Q9D1H7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026976 ; ENSMUSP00000026976 ; ENSMUSG00000025858 . [Q9D1H7-1 ]
    ENSMUST00000110878 ; ENSMUSP00000106502 ; ENSMUSG00000025858 .
    GeneIDi 67604.
    KEGGi mmu:67604.
    UCSCi uc009agg.2. mouse. [Q9D1H7-1 ]

    Organism-specific databases

    CTDi 51608.
    MGIi MGI:1914854. Get4.

    Phylogenomic databases

    eggNOGi NOG252493.
    GeneTreei ENSGT00390000015750.
    HOGENOMi HOG000264232.
    HOVERGENi HBG059877.
    InParanoidi Q9D1H7.
    OMAi LLNFISM.
    OrthoDBi EOG7PZRZ1.
    PhylomeDBi Q9D1H7.
    TreeFami TF315163.

    Miscellaneous databases

    NextBioi 325021.
    PROi Q9D1H7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D1H7.
    Bgeei Q9D1H7.
    CleanExi MM_1110007L15RIK.
    Genevestigatori Q9D1H7.

    Family and domain databases

    InterProi IPR007317. UPF0363.
    [Graphical view ]
    PANTHERi PTHR12875. PTHR12875. 1 hit.
    Pfami PF04190. DUF410. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiGET4_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1H7
    Secondary accession number(s): Q78J86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3