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Q9D1H7 (GET4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi to ER traffic protein 4 homolog
Gene names
Name:Get4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting By similarity.

Subunit structure

Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35 By similarity.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the GET4 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtail-anchored membrane protein insertion into ER membrane

Inferred from sequence or structural similarity. Source: UniProtKB

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentBAT3 complex

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9D1H7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q9D1H7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-53: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 327326Golgi to ER traffic protein 4 homolog
PRO_0000228105

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Alternative sequence2 – 5352Missing in isoform 2.
VSP_017653

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: 04B8DCC8E75FB022

FASTA32736,525
        10         20         30         40         50         60 
MAAAAAMAEQ EGARNGARNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQSKHA 

        70         80         90        100        110        120 
EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVDV ADELLENLAK VFSLMDPNSP 

       130        140        150        160        170        180 
ERVAFVSRAL KWSSGGSGKL GHPRLHQLLA LTLWKEQNYC ESRYHFLHSS DGEGCANMLV 

       190        200        210        220        230        240 
EYSTARGFRS EVDMFVAQAV LQFLCLKNKN SALVVFTTYT QKHPSIEDGP PFVQPLLNFI 

       250        260        270        280        290        300 
WFLLLAVDGG KLAVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN 

       310        320 
LLSSLMGSSE QEEGEESQDD SSPIELD 

« Hide

Isoform 2 [UniParc].

Checksum: FCAB666888DD31FD
Show »

FASTA27530,691

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK003551 mRNA. Translation: BAB22851.2.
BC019557 mRNA. Translation: AAH19557.1.
CCDSCCDS19805.1. [Q9D1H7-1]
CCDS51682.1. [Q9D1H7-2]
RefSeqNP_001156788.1. NM_001163316.1.
NP_080545.2. NM_026269.2. [Q9D1H7-1]
UniGeneMm.270137.

3D structure databases

ProteinModelPortalQ9D1H7.
SMRQ9D1H7. Positions 16-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212305. 1 interaction.

PTM databases

PhosphoSiteQ9D1H7.

Proteomic databases

MaxQBQ9D1H7.
PaxDbQ9D1H7.
PRIDEQ9D1H7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026976; ENSMUSP00000026976; ENSMUSG00000025858. [Q9D1H7-1]
ENSMUST00000110878; ENSMUSP00000106502; ENSMUSG00000025858.
GeneID67604.
KEGGmmu:67604.
UCSCuc009agg.2. mouse. [Q9D1H7-1]

Organism-specific databases

CTD51608.
MGIMGI:1914854. Get4.

Phylogenomic databases

eggNOGNOG252493.
GeneTreeENSGT00390000015750.
HOGENOMHOG000264232.
HOVERGENHBG059877.
InParanoidQ9D1H7.
OMALLNFISM.
OrthoDBEOG7PZRZ1.
PhylomeDBQ9D1H7.
TreeFamTF315163.

Gene expression databases

ArrayExpressQ9D1H7.
BgeeQ9D1H7.
CleanExMM_1110007L15RIK.
GenevestigatorQ9D1H7.

Family and domain databases

InterProIPR007317. UPF0363.
[Graphical view]
PANTHERPTHR12875. PTHR12875. 1 hit.
PfamPF04190. DUF410. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio325021.
PROQ9D1H7.
SOURCESearch...

Entry information

Entry nameGET4_MOUSE
AccessionPrimary (citable) accession number: Q9D1H7
Secondary accession number(s): Q78J86
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot