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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

Gene

Ndufaf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrial respiratory chain complex I assembly Source: MGI
  • NADH dehydrogenase complex assembly Source: MGI

Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
Alternative name(s):
Hormone-regulated proliferation-associated protein of 20 kDa homolog
Gene namesi
Name:Ndufaf4
Synonyms:Hrpap20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915743. Ndufaf4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002209892 – 173NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei35PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine. Prolactin stimulate serine phosphorylation (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9D1H6.
MaxQBiQ9D1H6.
PaxDbiQ9D1H6.
PeptideAtlasiQ9D1H6.
PRIDEiQ9D1H6.

PTM databases

iPTMnetiQ9D1H6.
PhosphoSitePlusiQ9D1H6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028261.
CleanExiMM_1110007M04RIK.
ExpressionAtlasiQ9D1H6. baseline and differential.
GenevisibleiQ9D1H6. MM.

Interactioni

Subunit structurei

Binds calmodulin. Interacts with NDUFAF3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029925.

Structurei

3D structure databases

ProteinModelPortaliQ9D1H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDUFAF4 family.Curated

Phylogenomic databases

eggNOGiKOG4481. Eukaryota.
ENOG4111W8K. LUCA.
GeneTreeiENSGT00390000001627.
HOGENOMiHOG000231584.
InParanoidiQ9D1H6.
KOiK18161.
OMAiKFINDHQ.
OrthoDBiEOG091G0YY3.
PhylomeDBiQ9D1H6.
TreeFamiTF323532.

Family and domain databases

InterProiView protein in InterPro
IPR009622. NDUFAF4.
PANTHERiPTHR13338. PTHR13338. 1 hit.
PfamiView protein in Pfam
PF06784. UPF0240. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD339506. UPF0240. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARVTRALR NFNVEKRAER EISKRKPSMA PKHPSTRDLL QEHRSQYPEI
60 70 80 90 100
EEVVSKKDNK LLSLLRDVYV DSKDPVPALP VKVEPRQEPK EFRLPIGNHF
110 120 130 140 150
DKNITDIPKG KITVVEALTL LNNHKLSPET WTAEKIAQEY YLELKDVNSL
160 170
LKYFVTFEVK ILPPEDRKAI QSK
Length:173
Mass (Da):20,082
Last modified:June 1, 2001 - v1
Checksum:i80EEED8C3E3CBF6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003553 mRNA. Translation: BAB22852.1.
AK034728 mRNA. Translation: BAC28809.1.
AK160341 mRNA. Translation: BAE35747.1.
BC028764 mRNA. Translation: AAH28764.1.
CCDSiCCDS18007.1.
RefSeqiNP_081018.1. NM_026742.4.
UniGeneiMm.204831.

Genome annotation databases

EnsembliENSMUST00000029925; ENSMUSP00000029925; ENSMUSG00000028261.
GeneIDi68493.
KEGGimmu:68493.
UCSCiuc008sed.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiNDUF4_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H6
Secondary accession number(s): Q3TV72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families