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Protein
Submitted name:

MCG4778

Gene

Muc16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of interleukin-6 biosynthetic process Source: MGI
  • negative regulation of wound healing Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-913709. O-linked glycosylation of mucins.
R-MMU-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
MCG4778Imported
Submitted name:
Protein Muc16Imported
Gene namesi
Name:Muc16Imported
ORF Names:mCG_4778Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920982. Muc16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei203 – 229HelicalSequence analysisAdd BLAST27

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000032134.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034653.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVZNMR-A67-185[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 189SEAInterPro annotationAdd BLAST121

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEHG. Eukaryota.
ENOG4111B0P. LUCA.
GeneTreeiENSGT00440000039287.
HOGENOMiHOG000185212.
OrthoDBiEOG091G00SO.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR028850. MUC16.
IPR000082. SEA_dom.
[Graphical view]
PANTHERiPTHR14672. PTHR14672. 1 hit.
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D1H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGSTVVTL EALFSSHLDP NLVKQVFLNK TLNASSHWLG ATYQLKDLHV
60 70 80 90 100
IDMKTSILLP AEIPTTSSSS QHFNLNFTIT NLPYSQDIAQ PSTTKYQQTK
110 120 130 140 150
RSIENALNQL FRNSSIKSYF SDCQVLAFRS VSNNNNHTGV DSLCNFSPLA
160 170 180 190 200
RRVDRVAIYE EFLRMTHNGT QLLNFTLDRK SVFVDGYSQN RDDDVMKNSG
210 220 230 240 250
LPFWAIILIC LAVLLVLITC LMCCFLVTVC RRKKEGDYQV QRHRLAYYLS

HLDLRKLQ
Length:258
Mass (Da):29,426
Last modified:June 1, 2001 - v1
Checksum:iB64D9B63394D84E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154519 Genomic DNA. No translation available.
AC154784 Genomic DNA. No translation available.
AC162941 Genomic DNA. No translation available.
AK003577 mRNA. Translation: BAB22869.1.
CH466522 Genomic DNA. Translation: EDL25052.1.
UniGeneiMm.490076.

Genome annotation databases

EnsembliENSMUST00000034653; ENSMUSP00000034653; ENSMUSG00000109564.
UCSCiuc009ogv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154519 Genomic DNA. No translation available.
AC154784 Genomic DNA. No translation available.
AC162941 Genomic DNA. No translation available.
AK003577 mRNA. Translation: BAB22869.1.
CH466522 Genomic DNA. Translation: EDL25052.1.
UniGeneiMm.490076.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVZNMR-A67-185[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034653; ENSMUSP00000034653; ENSMUSG00000109564.
UCSCiuc009ogv.1. mouse.

Organism-specific databases

MGIiMGI:1920982. Muc16.

Phylogenomic databases

eggNOGiENOG410IEHG. Eukaryota.
ENOG4111B0P. LUCA.
GeneTreeiENSGT00440000039287.
HOGENOMiHOG000185212.
OrthoDBiEOG091G00SO.

Enzyme and pathway databases

ReactomeiR-MMU-913709. O-linked glycosylation of mucins.
R-MMU-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032134.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR028850. MUC16.
IPR000082. SEA_dom.
[Graphical view]
PANTHERiPTHR14672. PTHR14672. 1 hit.
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9D1H1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.