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Protein

RBPJ-interacting and tubulin-associated protein 1

Gene

Rita1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
RBPJ-interacting and tubulin-associated protein 1
Alternative name(s):
RBPJ-interacting and tubulin-associated protein
Gene namesi
Name:Rita1
Synonyms:Rita
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1922021. Rita1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253RBPJ-interacting and tubulin-associated protein 1PRO_0000294430Add
BLAST

Proteomic databases

MaxQBiQ9D1H0.
PaxDbiQ9D1H0.
PRIDEiQ9D1H0.

PTM databases

PhosphoSiteiQ9D1H0.

Expressioni

Gene expression databases

BgeeiQ9D1H0.
CleanExiMM_1110008J03RIK.
ExpressionAtlasiQ9D1H0. baseline and differential.
GenevisibleiQ9D1H0. MM.

Interactioni

Subunit structurei

Interacts with RBPJ/RBPSUH.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9D1H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni112 – 14029Interaction with RBPJ/RBPSUHBy similarityAdd
BLAST
Regioni140 – 253114Interaction with tubulinBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 9717Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the RITA family.Curated

Phylogenomic databases

eggNOGiENOG410IKKU. Eukaryota.
ENOG411251C. LUCA.
GeneTreeiENSGT00390000013005.
HOVERGENiHBG101945.
InParanoidiQ9D1H0.
OMAiFDPPWVE.
PhylomeDBiQ9D1H0.
TreeFamiTF337291.

Family and domain databases

InterProiIPR031418. RITA1.
[Graphical view]
PfamiPF17066. RITA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D1H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALHLQHRS PTSYRVKARA SYVDETLFGS PARTRPAQPD FDPPWVQNCN
60 70 80 90 100
RSRGVGPGPP KGSLAKRDCE SPSSRGSTPN LTPRKKNKYR LIGHAPSYCD
110 120 130 140 150
ESLFGTSKEG SRMAVGDAAK LRTLFWTPPA TPRGSHTPCP RETPLRAIHP
160 170 180 190 200
AGPSRTEPRV TAGSQMSSQD GLCVPCSLGQ RRSHSLTHLT VPSTGHPASS
210 220 230 240 250
APQTNGPWSP RPNTSGATVQ SPLVTSKACS GRVSGPAPPR RGACPPKPKP

PWK
Length:253
Mass (Da):27,071
Last modified:June 1, 2001 - v1
Checksum:i239EC9BD9CF4FA61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003581 mRNA. Translation: BAB22871.1.
BC021365 mRNA. Translation: AAH21365.1.
CCDSiCCDS51635.1.
RefSeqiNP_083372.1. NM_029096.3.
NP_598669.1. NM_133908.1.
UniGeneiMm.9654.

Genome annotation databases

EnsembliENSMUST00000031599; ENSMUSP00000031599; ENSMUSG00000029600.
ENSMUST00000177800; ENSMUSP00000136946; ENSMUSG00000029600.
GeneIDi100764.
KEGGimmu:100764.
UCSCiuc008zhp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003581 mRNA. Translation: BAB22871.1.
BC021365 mRNA. Translation: AAH21365.1.
CCDSiCCDS51635.1.
RefSeqiNP_083372.1. NM_029096.3.
NP_598669.1. NM_133908.1.
UniGeneiMm.9654.

3D structure databases

ProteinModelPortaliQ9D1H0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9D1H0.

Proteomic databases

MaxQBiQ9D1H0.
PaxDbiQ9D1H0.
PRIDEiQ9D1H0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031599; ENSMUSP00000031599; ENSMUSG00000029600.
ENSMUST00000177800; ENSMUSP00000136946; ENSMUSG00000029600.
GeneIDi100764.
KEGGimmu:100764.
UCSCiuc008zhp.2. mouse.

Organism-specific databases

CTDi84934.
MGIiMGI:1922021. Rita1.

Phylogenomic databases

eggNOGiENOG410IKKU. Eukaryota.
ENOG411251C. LUCA.
GeneTreeiENSGT00390000013005.
HOVERGENiHBG101945.
InParanoidiQ9D1H0.
OMAiFDPPWVE.
PhylomeDBiQ9D1H0.
TreeFamiTF337291.

Miscellaneous databases

NextBioi354636.
PROiQ9D1H0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D1H0.
CleanExiMM_1110008J03RIK.
ExpressionAtlasiQ9D1H0. baseline and differential.
GenevisibleiQ9D1H0. MM.

Family and domain databases

InterProiIPR031418. RITA1.
[Graphical view]
PfamiPF17066. RITA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRITA1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.