Q9D1H0 (RITA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RBPJ-interacting and tubulin-associated protein

Gene names

Name:

Rita

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis By similarity.
Subunit structure	Interacts with RBPJ/RBPSUH By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Note: Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear By similarity.
Sequence similarities	Belongs to the RITA family.

Ontologies

Keywords
Biological process	Neurogenesis Notch signaling pathway
Cellular component	Cytoplasm Cytoskeleton Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Notch signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of Notch signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB neurogenesis Inferred from sequence or structural similarity. Source: UniProtKB nuclear export Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	centrosome Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	tubulin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	RBPJ-interacting and tubulin-associated protein		PRO_0000294430
Regions
	Region	112 – 140	29	Interaction with RBPJ/RBPSUH By similarity
	Region	140 – 253	114	Interaction with tubulin By similarity
	Motif	81 – 97	17	Nuclear localization signal By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9D1H0 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 239EC9BD9CF4FA61	FASTA	253	27,071
	10 20 30 40 50 60 MKALHLQHRS PTSYRVKARA SYVDETLFGS PARTRPAQPD FDPPWVQNCN RSRGVGPGPP 70 80 90 100 110 120 KGSLAKRDCE SPSSRGSTPN LTPRKKNKYR LIGHAPSYCD ESLFGTSKEG SRMAVGDAAK 130 140 150 160 170 180 LRTLFWTPPA TPRGSHTPCP RETPLRAIHP AGPSRTEPRV TAGSQMSSQD GLCVPCSLGQ 190 200 210 220 230 240 RRSHSLTHLT VPSTGHPASS APQTNGPWSP RPNTSGATVQ SPLVTSKACS GRVSGPAPPR 250 RGACPPKPKP PWK

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK003581 mRNA. Translation: BAB22871.1. BC021365 mRNA. Translation: AAH21365.1.
IPI	IPI00133730.
RefSeq	NP_083372.1. NM_029096.3. NP_598669.1. NM_133908.1.
UniGene	Mm.9654.
3D structure databases
ProteinModelPortal	Q9D1H0.
ModBase	Search...
Proteomic databases
PRIDE	Q9D1H0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031599; ENSMUSP00000031599; ENSMUSG00000029600.
GeneID	100764.
KEGG	mmu:100764.
UCSC	uc008zhp.2. mouse.
Organism-specific databases
MGI	MGI:1922021. 1110008J03Rik.
Phylogenomic databases
eggNOG	roNOG15535.
GeneTree	ENSGT00390000013005.
HOGENOM	HBG126487.
HOVERGEN	HBG101945.
InParanoid	Q9D1H0.
OMA	ANRTRGV.
OrthoDB	EOG47SSF9.
PhylomeDB	Q9D1H0.
Gene expression databases
ArrayExpress	Q9D1H0.
Bgee	Q9D1H0.
CleanEx	MM_1110008J03RIK.
Genevestigator	Q9D1H0.
Family and domain databases
ProtoNet	Search...
Other
NextBio	354636.
SOURCE	Search...

Entry information

Entry name

RITA_MOUSE

Accession

Primary (citable) accession number: Q9D1H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	June 1, 2001
Last modified:	September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program