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Protein

Phosphomevalonate kinase

Gene

Pmvk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.

Pathwayi: isopentenyl diphosphate biosynthesis via mevalonate pathway

This protein is involved in step 2 of the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Mevalonate kinase (Mvk), Mevalonate kinase (Mvk)
  2. Phosphomevalonate kinase (Pmvk), Phosphomevalonate kinase (Pmvk), Phosphomevalonate kinase (Pmvk)
  3. no protein annotated in this organism
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate, the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141ATPBy similarity1
Binding sitei170SubstrateBy similarity1
Binding sitei171ATPBy similarity1
Binding sitei180ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 23ATPBy similarity7

GO - Molecular functioni

  • ATP binding Source: MGI
  • phosphomevalonate kinase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-191273. Cholesterol biosynthesis.
R-MMU-2426168. Activation of gene expression by SREBF (SREBP).
UniPathwayiUPA00057; UER00099.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomevalonate kinase (EC:2.7.4.2)
Short name:
PMKase
Gene namesi
Name:Pmvk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915853. Pmvk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584731 – 192Phosphomevalonate kinaseAdd BLAST192

Proteomic databases

EPDiQ9D1G2.
PaxDbiQ9D1G2.
PeptideAtlasiQ9D1G2.
PRIDEiQ9D1G2.

PTM databases

iPTMnetiQ9D1G2.
PhosphoSitePlusiQ9D1G2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027952.
CleanExiMM_PMVK.
ExpressionAtlasiQ9D1G2. baseline and differential.
GenevisibleiQ9D1G2. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi212946. 1 interactor.
STRINGi10090.ENSMUSP00000029564.

Structurei

3D structure databases

ProteinModelPortaliQ9D1G2.
SMRiQ9D1G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi190 – 192Microbody targeting signalSequence analysis3

Phylogenomic databases

eggNOGiENOG410IZWN. Eukaryota.
ENOG4111IXB. LUCA.
GeneTreeiENSGT00390000014801.
HOGENOMiHOG000261666.
HOVERGENiHBG003277.
InParanoidiQ9D1G2.
KOiK13273.
OMAiKNDIKWF.
OrthoDBiEOG091G0PNO.
PhylomeDBiQ9D1G2.
TreeFamiTF312935.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005919. Pmev_kin_anim.
[Graphical view]
PANTHERiPTHR13101. PTHR13101. 1 hit.
PfamiPF04275. P-mevalo_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF036639. PMK_anim. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01223. Pmev_kin_anim. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D1G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLGASPRL VLLFSGKRKS GKDFVTERLK SRLGGNICAL LRLSGPLKEE
60 70 80 90 100
YAREHGLDFQ RLLDASTYKE TYRRDMICWG EQKRQADPGF FCRKIVEGVS
110 120 130 140 150
QPIWLVSDTR RTSDIQWFQE AYGAVIQTVR VVASEQSRQQ RGWVFTPGVD
160 170 180 190
DAESECGLDN FGNFDWVIEN HGDEQCLEDQ LEHLLGFIQA KL
Length:192
Mass (Da):21,916
Last modified:January 23, 2007 - v3
Checksum:i153155EC22693857
GO
Isoform 2 (identifier: Q9D1G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-31: KDFVTERLKS → MAGIYGIFYA

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):19,631
Checksum:iA85B622BA1124491
GO
Isoform 3 (identifier: Q9D1G2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:117
Mass (Da):13,436
Checksum:i07000CCC843DE39A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147P → L in BAB22886 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0076491 – 75Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_0076501 – 21Missing in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_00765122 – 31KDFVTERLKS → MAGIYGIFYA in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003607 mRNA. Translation: BAB22886.1.
AK013477 mRNA. Translation: BAB28875.1.
BC028659 mRNA. Translation: AAH28659.1.
CCDSiCCDS17511.1. [Q9D1G2-1]
CCDS71270.1. [Q9D1G2-2]
CCDS79953.1. [Q9D1G2-3]
RefSeqiNP_001297569.1. NM_001310640.1. [Q9D1G2-3]
NP_081060.2. NM_026784.3. [Q9D1G2-1]
NP_081624.1. NM_027348.1. [Q9D1G2-2]
UniGeneiMm.34242.

Genome annotation databases

EnsembliENSMUST00000029564; ENSMUSP00000029564; ENSMUSG00000027952. [Q9D1G2-1]
ENSMUST00000184515; ENSMUSP00000139116; ENSMUSG00000027952. [Q9D1G2-2]
ENSMUST00000198440; ENSMUSP00000143154; ENSMUSG00000027952. [Q9D1G2-3]
GeneIDi68603.
KEGGimmu:68603.
UCSCiuc008pzs.2. mouse. [Q9D1G2-1]
uc012csn.1. mouse. [Q9D1G2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003607 mRNA. Translation: BAB22886.1.
AK013477 mRNA. Translation: BAB28875.1.
BC028659 mRNA. Translation: AAH28659.1.
CCDSiCCDS17511.1. [Q9D1G2-1]
CCDS71270.1. [Q9D1G2-2]
CCDS79953.1. [Q9D1G2-3]
RefSeqiNP_001297569.1. NM_001310640.1. [Q9D1G2-3]
NP_081060.2. NM_026784.3. [Q9D1G2-1]
NP_081624.1. NM_027348.1. [Q9D1G2-2]
UniGeneiMm.34242.

3D structure databases

ProteinModelPortaliQ9D1G2.
SMRiQ9D1G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212946. 1 interactor.
STRINGi10090.ENSMUSP00000029564.

PTM databases

iPTMnetiQ9D1G2.
PhosphoSitePlusiQ9D1G2.

Proteomic databases

EPDiQ9D1G2.
PaxDbiQ9D1G2.
PeptideAtlasiQ9D1G2.
PRIDEiQ9D1G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029564; ENSMUSP00000029564; ENSMUSG00000027952. [Q9D1G2-1]
ENSMUST00000184515; ENSMUSP00000139116; ENSMUSG00000027952. [Q9D1G2-2]
ENSMUST00000198440; ENSMUSP00000143154; ENSMUSG00000027952. [Q9D1G2-3]
GeneIDi68603.
KEGGimmu:68603.
UCSCiuc008pzs.2. mouse. [Q9D1G2-1]
uc012csn.1. mouse. [Q9D1G2-2]

Organism-specific databases

CTDi10654.
MGIiMGI:1915853. Pmvk.

Phylogenomic databases

eggNOGiENOG410IZWN. Eukaryota.
ENOG4111IXB. LUCA.
GeneTreeiENSGT00390000014801.
HOGENOMiHOG000261666.
HOVERGENiHBG003277.
InParanoidiQ9D1G2.
KOiK13273.
OMAiKNDIKWF.
OrthoDBiEOG091G0PNO.
PhylomeDBiQ9D1G2.
TreeFamiTF312935.

Enzyme and pathway databases

UniPathwayiUPA00057; UER00099.
ReactomeiR-MMU-191273. Cholesterol biosynthesis.
R-MMU-2426168. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

PROiQ9D1G2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027952.
CleanExiMM_PMVK.
ExpressionAtlasiQ9D1G2. baseline and differential.
GenevisibleiQ9D1G2. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005919. Pmev_kin_anim.
[Graphical view]
PANTHERiPTHR13101. PTHR13101. 1 hit.
PfamiPF04275. P-mevalo_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF036639. PMK_anim. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01223. Pmev_kin_anim. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMVK_MOUSE
AccessioniPrimary (citable) accession number: Q9D1G2
Secondary accession number(s): Q8R021, Q9D6K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.