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Q9D1G1

- RAB1B_MOUSE

UniProt

Q9D1G1 - RAB1B_MOUSE

Protein

Ras-related protein Rab-1B

Gene

Rab1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi121 – 1244GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-1B
    Gene namesi
    Name:Rab1b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1923558. Rab1b.

    Subcellular locationi

    Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm
    Note: Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm By similarity.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment Source: MGI
    2. Golgi apparatus Source: Ensembl
    3. membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Ras-related protein Rab-1BPRO_0000121062Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei76 – 761O-(2-cholinephosphoryl)serineBy similarity
    Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
    Modified residuei201 – 2011Cysteine methyl esterSequence Analysis
    Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity

    Post-translational modificationi

    Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).By similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ9D1G1.
    PaxDbiQ9D1G1.
    PRIDEiQ9D1G1.

    PTM databases

    PhosphoSiteiQ9D1G1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D1G1.
    BgeeiQ9D1G1.
    CleanExiMM_RAB1B.
    GenevestigatoriQ9D1G1.

    Interactioni

    Subunit structurei

    Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II By similarity.By similarity

    Protein-protein interaction databases

    BioGridi218071. 1 interaction.
    IntActiQ9D1G1. 2 interactions.
    MINTiMINT-4998063.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D1G1.
    SMRiQ9D1G1. Positions 4-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 8320Switch 2 region; required for interaction with REP1/CHMBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00720000108592.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ9D1G1.
    KOiK07875.
    OMAiTMHASEY.
    OrthoDBiEOG7VB2H4.
    PhylomeDBiQ9D1G1.
    TreeFamiTF300097.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D1G1-1 [UniParc]FASTAAdd to Basket

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    MNPEYDYLFK LLLIGDSGVG KSCLLLRFAD DTYTESYIST IGVDFKIRTI    50
    ELDGKTIKLQ IWDTAGQERF RTITSSYYRG AHGIIVVYDV TDQESYANVK 100
    QWLQEIDRYA SENVNKLLVG NKSDLTTKKV VDNTTAKEFA DSLGVPFLET 150
    SAKNATNVEQ AFMTMAAEIK KRMGPGAASG GERPNLKIDS TPVKPASGGC 200
    C 201
    Length:201
    Mass (Da):22,187
    Last modified:June 1, 2001 - v1
    Checksum:i870DFF52AEF4B2BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003609 mRNA. Translation: BAB22888.1.
    AK156726 mRNA. Translation: BAE33821.1.
    BC016408 mRNA. Translation: AAH16408.1.
    CCDSiCCDS29452.1.
    RefSeqiNP_083852.1. NM_029576.3.
    UniGeneiMm.182563.

    Genome annotation databases

    EnsembliENSMUST00000025804; ENSMUSP00000025804; ENSMUSG00000024870.
    GeneIDi76308.
    KEGGimmu:76308.
    UCSCiuc008gcf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003609 mRNA. Translation: BAB22888.1 .
    AK156726 mRNA. Translation: BAE33821.1 .
    BC016408 mRNA. Translation: AAH16408.1 .
    CCDSi CCDS29452.1.
    RefSeqi NP_083852.1. NM_029576.3.
    UniGenei Mm.182563.

    3D structure databases

    ProteinModelPortali Q9D1G1.
    SMRi Q9D1G1. Positions 4-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218071. 1 interaction.
    IntActi Q9D1G1. 2 interactions.
    MINTi MINT-4998063.

    PTM databases

    PhosphoSitei Q9D1G1.

    Proteomic databases

    MaxQBi Q9D1G1.
    PaxDbi Q9D1G1.
    PRIDEi Q9D1G1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025804 ; ENSMUSP00000025804 ; ENSMUSG00000024870 .
    GeneIDi 76308.
    KEGGi mmu:76308.
    UCSCi uc008gcf.1. mouse.

    Organism-specific databases

    CTDi 81876.
    MGIi MGI:1923558. Rab1b.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00720000108592.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q9D1G1.
    KOi K07875.
    OMAi TMHASEY.
    OrthoDBi EOG7VB2H4.
    PhylomeDBi Q9D1G1.
    TreeFami TF300097.

    Miscellaneous databases

    ChiTaRSi RAB1B. mouse.
    NextBioi 344943.
    PROi Q9D1G1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D1G1.
    Bgeei Q9D1G1.
    CleanExi MM_RAB1B.
    Genevestigatori Q9D1G1.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 11-21; 59-69; 72-100; 109-122; 138-153 AND 173-187, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiRAB1B_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1G1
    Secondary accession number(s): Q3U0N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.By similarity

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3