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Protein
Submitted name:

Protein Slc37a4

Gene

Slc37a4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: MGI
  • cholesterol homeostasis Source: MGI
  • cytokine production Source: MGI
  • glucose-6-phosphate transport Source: MGI
  • glucose homeostasis Source: ParkinsonsUK-UCL
  • glycogen metabolic process Source: MGI
  • lactate metabolic process Source: MGI
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • myeloid progenitor cell differentiation Source: MGI
  • negative regulation of chemokine production Source: MGI
  • neutrophil chemotaxis Source: MGI
  • neutrophil homeostasis Source: MGI
  • positive regulation of catalytic activity Source: MGI
  • positive regulation of defense response to virus by host Source: MGI
  • post-embryonic hemopoiesis Source: MGI
  • respiratory burst Source: MGI
  • response to glucose Source: Ensembl
  • response to nutrient Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • steroid metabolic process Source: MGI
  • triglyceride metabolic process Source: MGI
  • xenophagy Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Slc37a4Imported
Submitted name:
Solute carrier family 37 (Glucose-6-phosphate transporter), member 4Imported
Submitted name:
Solute carrier family 37 (Glycerol-6-phosphate transporter), member 4Imported
Gene namesi
Name:Slc37a4Imported
ORF Names:mCG_10718Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1316650. Slc37a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei84 – 10926HelicalSequence analysisAdd
BLAST
Transmembranei137 – 16024HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24723HelicalSequence analysisAdd
BLAST
Transmembranei259 – 28325HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32220HelicalSequence analysisAdd
BLAST
Transmembranei329 – 35325HelicalSequence analysisAdd
BLAST
Transmembranei365 – 38420HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41419HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129564.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 419407MFSInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00730000111086.
HOVERGENiHBG051682.
KOiK08171.
OMAiCLLLIRN.
OrthoDBiEOG70CR7M.
TreeFamiTF314991.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00881. 2A0104. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D1F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQGYGYYR TVIFAAMFGG YSLYYFNRKT FSFVMPSLVD EIALDKDDLG
60 70 80 90 100
LITSSQSAAY AISKFVSGVL SDQMSARWLF SSGLLLVGLV NVVFSWSSTV
110 120 130 140 150
SAFAALWFLN GLAQGLGWPP CGKILRKWFE PSQFGTWWAV LSTSMNLAGS
160 170 180 190 200
LGPILATILA QSYSWRSTLA LSGALCVVVS FFCLLLIHNE PADVGLRNLD
210 220 230 240 250
PAPSKGKKGS SKEESTLQDL LLSPYLWVLS TGYLVVFGVK TCCTDWGQFF
260 270 280 290 300
LIQERGQSAL VGSSYISALE VGGLVGSIAA GYLSDRAMAK AGLSLYGNPR
310 320 330 340 350
HGLLLLMMAG MAASMFLFRV TVTSDSPKIW ILVLGAVFGF SSYGPIALFG
360 370 380 390 400
VIANESAPPN LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA
410 420
EVVCGASTVV FFLLRNIRTK MGRVSKKGE
Length:429
Mass (Da):46,064
Last modified:June 1, 2001 - v1
Checksum:i8C210CB489BC376E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122428 Genomic DNA. No translation available.
BC075655 mRNA. Translation: AAH75655.1.
AK003620 mRNA. Translation: BAB22894.1.
AK155339 mRNA. Translation: BAE33203.1.
CH466522 Genomic DNA. Translation: EDL25587.1.
RefSeqiNP_001280559.1. NM_001293630.1.
NP_001280560.1. NM_001293631.1.
NP_032089.2. NM_008063.2.
XP_006510076.1. XM_006510013.2.
UniGeneiMm.30087.
Mm.486672.

Genome annotation databases

EnsembliENSMUST00000165839; ENSMUSP00000129564; ENSMUSG00000032114.
GeneIDi14385.
KEGGimmu:14385.
UCSCiuc009pdh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122428 Genomic DNA. No translation available.
BC075655 mRNA. Translation: AAH75655.1.
AK003620 mRNA. Translation: BAB22894.1.
AK155339 mRNA. Translation: BAE33203.1.
CH466522 Genomic DNA. Translation: EDL25587.1.
RefSeqiNP_001280559.1. NM_001293630.1.
NP_001280560.1. NM_001293631.1.
NP_032089.2. NM_008063.2.
XP_006510076.1. XM_006510013.2.
UniGeneiMm.30087.
Mm.486672.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129564.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165839; ENSMUSP00000129564; ENSMUSG00000032114.
GeneIDi14385.
KEGGimmu:14385.
UCSCiuc009pdh.2. mouse.

Organism-specific databases

CTDi2542.
MGIiMGI:1316650. Slc37a4.

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00730000111086.
HOVERGENiHBG051682.
KOiK08171.
OMAiCLLLIRN.
OrthoDBiEOG70CR7M.
TreeFamiTF314991.

Miscellaneous databases

NextBioi285897.
SOURCEiSearch...

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00881. 2A0104. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Whole bodyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Whole bodyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Whole bodyImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Whole bodyImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: EyeImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Whole bodyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Whole bodyImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9D1F9_MOUSE
AccessioniPrimary (citable) accession number: Q9D1F9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.