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Protein

MRN complex-interacting protein

Gene

Mrnip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
MRN complex-interacting proteinImported
Alternative name(s):
MRN-interacting proteinBy similarity
Gene namesi
Name:MrnipImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915317 Mrnip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261201 – 335MRN complex-interacting proteinAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation is necessary for its nuclear retention.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D1F5
MaxQBiQ9D1F5
PaxDbiQ9D1F5
PeptideAtlasiQ9D1F5
PRIDEiQ9D1F5

PTM databases

iPTMnetiQ9D1F5
PhosphoSitePlusiQ9D1F5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020381
CleanExiMM_3010026O09RIK
ExpressionAtlasiQ9D1F5 baseline and differential
GenevisibleiQ9D1F5 MM

Interactioni

Subunit structurei

Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive. Interacts with MRE11. Interacts with NBN. Interacts with RAD50.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9D1F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 230Necessary for the association with the MRN complexBy similarityAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi145 – 148Nuclear localization signal (NLS)By similarity4

Sequence similaritiesi

Belongs to the MRNIP family.Curated

Phylogenomic databases

eggNOGiENOG410J2EG Eukaryota
ENOG411227Z LUCA
GeneTreeiENSGT00390000006124
HOGENOMiHOG000293216
HOVERGENiHBG106110
InParanoidiQ9D1F5
OMAiLCDLFKT
OrthoDBiEOG091G0IYR
PhylomeDBiQ9D1F5
TreeFamiTF333430

Family and domain databases

InterProiView protein in InterPro
IPR032739 MRNIP
PANTHERiPTHR15863 PTHR15863, 1 hit
PfamiView protein in Pfam
PF15749 MRNIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D1F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAQQSRVL RCCSCHIFQA HQVKKSLKWT CKACGEKQSF VRAYGEGSGA
60 70 80 90 100
DCRRHVQKLN LLQGQVSELS LRSVEEAVNG SEEENAGPLQ AEAGSQQAPS
110 120 130 140 150
KPLESRWLKY LDKGCEDQEL DRGRPALKTQ LSTSAERPSS PAQPRKRKWN
160 170 180 190 200
QRTGQPAHSL HGQGVDSVED NFEHQDSTGL FGTEQQGTSP ALSTANHTRE
210 220 230 240 250
LGFPRWKLPS PVTQVNAPSS KWARFLLAPG NSPQVDEKPS PLQEATMLAD
260 270 280 290 300
LAQGTVENKT PVEGHFSRAP AIRPPQAIHT TTPQLDRPDR KTREQPRDMG
310 320 330
TPRADGRPLA QGTQKAPPLQ LHNLFTTGED FDDDL
Length:335
Mass (Da):36,897
Last modified:June 1, 2001 - v1
Checksum:i4F24FDA35BEB6070
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti294E → G in BAB31698 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003636 mRNA Translation: BAB22904.1
AK019392 mRNA Translation: BAB31698.1
AL627187 Genomic DNA No translation available.
BC028428 mRNA Translation: AAH28428.1
CCDSiCCDS48784.1
RefSeqiNP_080819.2, NM_026543.3
UniGeneiMm.390357
Mm.40828

Genome annotation databases

EnsembliENSMUST00000020647; ENSMUSP00000020647; ENSMUSG00000020381
GeneIDi68067
KEGGimmu:68067
UCSCiuc007irv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMRNIP_MOUSE
AccessioniPrimary (citable) accession number: Q9D1F5
Secondary accession number(s): Q9CX85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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