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Q9D1E5 (LMBRL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein LMBR1L
Alternative name(s):
Uteroglobin receptor
Gene names
Name:Lmbr1l
Synonyms:D15Ertd735e, Kiaa1174
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable receptor which may mediate endocytosis of its ligand By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the LIMR family.

Sequence caution

The sequence BAD32399.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9D1E5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9D1E5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Protein LMBR1L
PRO_0000053912

Regions

Topological domain1 – 2121Extracellular Potential
Transmembrane22 – 4221Helical; Potential
Topological domain43 – 6624Cytoplasmic Potential
Transmembrane67 – 8721Helical; Potential
Topological domain88 – 11427Extracellular Potential
Transmembrane115 – 13521Helical; Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 17521Helical; Potential
Topological domain176 – 19621Extracellular Potential
Transmembrane197 – 21721Helical; Potential
Topological domain218 – 30588Cytoplasmic Potential
Transmembrane306 – 32621Helical; Potential
Topological domain327 – 35024Extracellular Potential
Transmembrane351 – 37121Helical; Potential
Topological domain372 – 38817Cytoplasmic Potential
Transmembrane389 – 40921Helical; Potential
Topological domain410 – 43122Extracellular Potential
Transmembrane432 – 45221Helical; Potential
Topological domain453 – 48937Cytoplasmic Potential

Natural variations

Alternative sequence1 – 127127Missing in isoform 2.
VSP_016897

Experimental info

Sequence conflict881S → G in BAE41722. Ref.3
Sequence conflict3031M → V in BAE41722. Ref.3
Sequence conflict3571V → A in BAE41722. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 50AA85EF2C58B79A

FASTA48954,958
        10         20         30         40         50         60 
MEAADYEVLS VREQLFHDRV RECIISILLF ATLYILCHIF LTRFKKPAEF TTVDDEDATV 

        70         80         90        100        110        120 
NKIALELCTF TLAVALGAVL LLPFSIISNE VLLSLPRNYY IQWLNGSLIH GLWNLVFLFS 

       130        140        150        160        170        180 
NLSLVFLMPF AYFFTESEGF AGSRKGVLGR VYETVVMLIL LTLLVLGMVW VASAIVDNDK 

       190        200        210        220        230        240 
ASRESLYDFW EYYLPYLYSC ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ 

       250        260        270        280        290        300 
LNCSAFEEAA LTRRICNPTS CWLPLDMELL HRQVLALQAQ RVLLEKRRKA SAWQRNLGYP 

       310        320        330        340        350        360 
LAMLCLLVLT GLSVLIVAVH ILELLIDEAA MPRGMQDAAL GQASFSKLGS FGAIIQVVLI 

       370        380        390        400        410        420 
FYLMVSSVVG FYSSPLFGSL RPRWHDTSMT QIIGNCVCLL VLSSALPVFS RTLGLTRFDL 

       430        440        450        460        470        480 
LGDFGRFNWL GNFYIVFLYN AAFAGLTTLC LVKTFTAAVR AELIRAFGLD RLPLPVSGFP 


RASRKKQHQ

« Hide

Isoform 2 [UniParc].

Checksum: 355918ADC596FF57
Show »

FASTA36240,436

References

« Hide 'large scale' references
[1]"Mouse uteroglobin receptor."
Mukherjee A.B., Zhang Z., Chowdhury B.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6J.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Cerebellum, Dendritic cell, Embryo, Kidney, Pituitary and Spleen.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY052398 mRNA. Translation: AAL13076.1.
AK173121 mRNA. Translation: BAD32399.1. Different initiation.
AK003656 mRNA. Translation: BAB22919.1.
AK030589 mRNA. Translation: BAC27033.1.
AK049110 mRNA. Translation: BAC33547.1.
AK143891 mRNA. Translation: BAE25586.1.
AK154968 mRNA. Translation: BAE32960.1.
AK170328 mRNA. Translation: BAE41722.1.
BC023397 mRNA. Translation: AAH23397.1.
IPIIPI00133656.
IPI00660736.
RefSeqNP_083374.1. NM_029098.3.
UniGeneMm.385020.

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ9D1E5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023736; ENSMUSP00000023736; ENSMUSG00000022999.
ENSMUST00000109127; ENSMUSP00000104755; ENSMUSG00000022999.
GeneID74775.
KEGGmmu:74775.
UCSCuc007xoi.1. mouse.

Organism-specific databases

CTD55716.
MGIMGI:1289247. Lmbr1l.
RougeSearch...

Phylogenomic databases

eggNOGNOG246746.
GeneTreeENSGT00390000007809.
HOGENOMHOG000252995.
HOVERGENHBG072983.
InParanoidQ9D1E5.
OMARVYETFT.
OrthoDBEOG4XWFXS.

Gene expression databases

BgeeQ9D1E5.
CleanExMM_LMBR1L.
GenevestigatorQ9D1E5.
GermOnlineENSMUSG00000022999. Mus musculus.

Family and domain databases

InterProIPR008075. Lipcalin_1_rcpt.
IPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamPF04791. LMBR1. 1 hit.
[Graphical view]
PRINTSPR01692. LIPOCALINIMR.
ProtoNetSearch...

Other

NextBio341610.
SOURCESearch...

Entry information

Entry nameLMBRL_MOUSE
AccessionPrimary (citable) accession number: Q9D1E5
Secondary accession number(s): Q3TD82, Q69ZP7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: March 6, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents