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Q9D1E5

- LMBRL_MOUSE

UniProt

Q9D1E5 - LMBRL_MOUSE

Protein

Protein LMBR1L

Gene

Lmbr1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Probable receptor which may mediate endocytosis of its ligand.By similarity

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein LMBR1L
    Alternative name(s):
    Uteroglobin receptor
    Gene namesi
    Name:Lmbr1l
    Synonyms:D15Ertd735e, Kiaa1174
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1289247. Lmbr1l.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Protein LMBR1LPRO_0000053912Add
    BLAST

    Proteomic databases

    PRIDEiQ9D1E5.

    Expressioni

    Gene expression databases

    BgeeiQ9D1E5.
    CleanExiMM_LMBR1L.
    GenevestigatoriQ9D1E5.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 6624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 11427ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 19621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 30588CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 35024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini372 – 38817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini410 – 43122ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini453 – 48937CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei389 – 40921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LIMR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG246746.
    GeneTreeiENSGT00390000007809.
    HOGENOMiHOG000252995.
    HOVERGENiHBG072983.
    InParanoidiQ9D1E5.
    OMAiRVYETFT.
    OrthoDBiEOG7M0NRC.
    PhylomeDBiQ9D1E5.
    TreeFamiTF313485.

    Family and domain databases

    InterProiIPR008075. Lipcalin_1_rcpt.
    IPR006876. LMBR1-like_membr_prot.
    [Graphical view]
    PfamiPF04791. LMBR1. 1 hit.
    [Graphical view]
    PRINTSiPR01692. LIPOCALINIMR.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D1E5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAADYEVLS VREQLFHDRV RECIISILLF ATLYILCHIF LTRFKKPAEF    50
    TTVDDEDATV NKIALELCTF TLAVALGAVL LLPFSIISNE VLLSLPRNYY 100
    IQWLNGSLIH GLWNLVFLFS NLSLVFLMPF AYFFTESEGF AGSRKGVLGR 150
    VYETVVMLIL LTLLVLGMVW VASAIVDNDK ASRESLYDFW EYYLPYLYSC 200
    ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ LNCSAFEEAA 250
    LTRRICNPTS CWLPLDMELL HRQVLALQAQ RVLLEKRRKA SAWQRNLGYP 300
    LAMLCLLVLT GLSVLIVAVH ILELLIDEAA MPRGMQDAAL GQASFSKLGS 350
    FGAIIQVVLI FYLMVSSVVG FYSSPLFGSL RPRWHDTSMT QIIGNCVCLL 400
    VLSSALPVFS RTLGLTRFDL LGDFGRFNWL GNFYIVFLYN AAFAGLTTLC 450
    LVKTFTAAVR AELIRAFGLD RLPLPVSGFP RASRKKQHQ 489
    Length:489
    Mass (Da):54,958
    Last modified:June 1, 2001 - v1
    Checksum:i50AA85EF2C58B79A
    GO
    Isoform 2 (identifier: Q9D1E5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-127: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:362
    Mass (Da):40,436
    Checksum:i355918ADC596FF57
    GO

    Sequence cautioni

    The sequence BAD32399.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881S → G in BAE41722. (PubMed:16141072)Curated
    Sequence conflicti303 – 3031M → V in BAE41722. (PubMed:16141072)Curated
    Sequence conflicti357 – 3571V → A in BAE41722. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 127127Missing in isoform 2. 1 PublicationVSP_016897Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY052398 mRNA. Translation: AAL13076.1.
    AK173121 mRNA. Translation: BAD32399.1. Different initiation.
    AK003656 mRNA. Translation: BAB22919.1.
    AK030589 mRNA. Translation: BAC27033.1.
    AK049110 mRNA. Translation: BAC33547.1.
    AK143891 mRNA. Translation: BAE25586.1.
    AK154968 mRNA. Translation: BAE32960.1.
    AK170328 mRNA. Translation: BAE41722.1.
    BC023397 mRNA. Translation: AAH23397.1.
    CCDSiCCDS27811.1. [Q9D1E5-1]
    RefSeqiNP_083374.1. NM_029098.3. [Q9D1E5-1]
    UniGeneiMm.385020.

    Genome annotation databases

    EnsembliENSMUST00000023736; ENSMUSP00000023736; ENSMUSG00000022999. [Q9D1E5-1]
    ENSMUST00000109127; ENSMUSP00000104755; ENSMUSG00000022999. [Q9D1E5-2]
    GeneIDi74775.
    KEGGimmu:74775.
    UCSCiuc007xoi.1. mouse. [Q9D1E5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY052398 mRNA. Translation: AAL13076.1 .
    AK173121 mRNA. Translation: BAD32399.1 . Different initiation.
    AK003656 mRNA. Translation: BAB22919.1 .
    AK030589 mRNA. Translation: BAC27033.1 .
    AK049110 mRNA. Translation: BAC33547.1 .
    AK143891 mRNA. Translation: BAE25586.1 .
    AK154968 mRNA. Translation: BAE32960.1 .
    AK170328 mRNA. Translation: BAE41722.1 .
    BC023397 mRNA. Translation: AAH23397.1 .
    CCDSi CCDS27811.1. [Q9D1E5-1 ]
    RefSeqi NP_083374.1. NM_029098.3. [Q9D1E5-1 ]
    UniGenei Mm.385020.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9D1E5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023736 ; ENSMUSP00000023736 ; ENSMUSG00000022999 . [Q9D1E5-1 ]
    ENSMUST00000109127 ; ENSMUSP00000104755 ; ENSMUSG00000022999 . [Q9D1E5-2 ]
    GeneIDi 74775.
    KEGGi mmu:74775.
    UCSCi uc007xoi.1. mouse. [Q9D1E5-1 ]

    Organism-specific databases

    CTDi 55716.
    MGIi MGI:1289247. Lmbr1l.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG246746.
    GeneTreei ENSGT00390000007809.
    HOGENOMi HOG000252995.
    HOVERGENi HBG072983.
    InParanoidi Q9D1E5.
    OMAi RVYETFT.
    OrthoDBi EOG7M0NRC.
    PhylomeDBi Q9D1E5.
    TreeFami TF313485.

    Miscellaneous databases

    NextBioi 341610.
    PROi Q9D1E5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D1E5.
    CleanExi MM_LMBR1L.
    Genevestigatori Q9D1E5.

    Family and domain databases

    InterProi IPR008075. Lipcalin_1_rcpt.
    IPR006876. LMBR1-like_membr_prot.
    [Graphical view ]
    Pfami PF04791. LMBR1. 1 hit.
    [Graphical view ]
    PRINTSi PR01692. LIPOCALINIMR.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse uteroglobin receptor."
      Mukherjee A.B., Zhang Z., Chowdhury B.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Cerebellum, Dendritic cell, Embryo, Kidney, Pituitary and Spleen.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiLMBRL_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1E5
    Secondary accession number(s): Q3TD82, Q69ZP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3