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Protein

Protein LMBR1L

Gene

Lmbr1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable receptor which may mediate endocytosis of its ligand.By similarity

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LMBR1L
Alternative name(s):
Uteroglobin receptor
Gene namesi
Name:Lmbr1l
Synonyms:D15Ertd735e, Kiaa1174
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1289247. Lmbr1l.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Topological domaini43 – 6624CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 11427ExtracellularSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Topological domaini176 – 19621ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Topological domaini218 – 30588CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Topological domaini327 – 35024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Topological domaini372 – 38817CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence AnalysisAdd
BLAST
Topological domaini410 – 43122ExtracellularSequence AnalysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence AnalysisAdd
BLAST
Topological domaini453 – 48937CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Protein LMBR1LPRO_0000053912Add
BLAST

Proteomic databases

PRIDEiQ9D1E5.

Expressioni

Gene expression databases

BgeeiQ9D1E5.
CleanExiMM_LMBR1L.
GenevestigatoriQ9D1E5.

Family & Domainsi

Sequence similaritiesi

Belongs to the LIMR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG246746.
GeneTreeiENSGT00390000007809.
HOGENOMiHOG000252995.
HOVERGENiHBG072983.
InParanoidiQ9D1E5.
OMAiRVYETFT.
OrthoDBiEOG7M0NRC.
PhylomeDBiQ9D1E5.
TreeFamiTF313485.

Family and domain databases

InterProiIPR008075. Lipcalin_1_rcpt.
IPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamiPF04791. LMBR1. 1 hit.
[Graphical view]
PRINTSiPR01692. LIPOCALINIMR.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D1E5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAADYEVLS VREQLFHDRV RECIISILLF ATLYILCHIF LTRFKKPAEF
60 70 80 90 100
TTVDDEDATV NKIALELCTF TLAVALGAVL LLPFSIISNE VLLSLPRNYY
110 120 130 140 150
IQWLNGSLIH GLWNLVFLFS NLSLVFLMPF AYFFTESEGF AGSRKGVLGR
160 170 180 190 200
VYETVVMLIL LTLLVLGMVW VASAIVDNDK ASRESLYDFW EYYLPYLYSC
210 220 230 240 250
ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ LNCSAFEEAA
260 270 280 290 300
LTRRICNPTS CWLPLDMELL HRQVLALQAQ RVLLEKRRKA SAWQRNLGYP
310 320 330 340 350
LAMLCLLVLT GLSVLIVAVH ILELLIDEAA MPRGMQDAAL GQASFSKLGS
360 370 380 390 400
FGAIIQVVLI FYLMVSSVVG FYSSPLFGSL RPRWHDTSMT QIIGNCVCLL
410 420 430 440 450
VLSSALPVFS RTLGLTRFDL LGDFGRFNWL GNFYIVFLYN AAFAGLTTLC
460 470 480
LVKTFTAAVR AELIRAFGLD RLPLPVSGFP RASRKKQHQ
Length:489
Mass (Da):54,958
Last modified:June 1, 2001 - v1
Checksum:i50AA85EF2C58B79A
GO
Isoform 2 (identifier: Q9D1E5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.

Show »
Length:362
Mass (Da):40,436
Checksum:i355918ADC596FF57
GO

Sequence cautioni

The sequence BAD32399.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881S → G in BAE41722 (PubMed:16141072).Curated
Sequence conflicti303 – 3031M → V in BAE41722 (PubMed:16141072).Curated
Sequence conflicti357 – 3571V → A in BAE41722 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 127127Missing in isoform 2. 1 PublicationVSP_016897Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052398 mRNA. Translation: AAL13076.1.
AK173121 mRNA. Translation: BAD32399.1. Different initiation.
AK003656 mRNA. Translation: BAB22919.1.
AK030589 mRNA. Translation: BAC27033.1.
AK049110 mRNA. Translation: BAC33547.1.
AK143891 mRNA. Translation: BAE25586.1.
AK154968 mRNA. Translation: BAE32960.1.
AK170328 mRNA. Translation: BAE41722.1.
BC023397 mRNA. Translation: AAH23397.1.
CCDSiCCDS27811.1. [Q9D1E5-1]
RefSeqiNP_083374.1. NM_029098.3. [Q9D1E5-1]
UniGeneiMm.385020.

Genome annotation databases

EnsembliENSMUST00000023736; ENSMUSP00000023736; ENSMUSG00000022999. [Q9D1E5-1]
ENSMUST00000109127; ENSMUSP00000104755; ENSMUSG00000022999. [Q9D1E5-2]
GeneIDi74775.
KEGGimmu:74775.
UCSCiuc007xoi.1. mouse. [Q9D1E5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052398 mRNA. Translation: AAL13076.1.
AK173121 mRNA. Translation: BAD32399.1. Different initiation.
AK003656 mRNA. Translation: BAB22919.1.
AK030589 mRNA. Translation: BAC27033.1.
AK049110 mRNA. Translation: BAC33547.1.
AK143891 mRNA. Translation: BAE25586.1.
AK154968 mRNA. Translation: BAE32960.1.
AK170328 mRNA. Translation: BAE41722.1.
BC023397 mRNA. Translation: AAH23397.1.
CCDSiCCDS27811.1. [Q9D1E5-1]
RefSeqiNP_083374.1. NM_029098.3. [Q9D1E5-1]
UniGeneiMm.385020.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9D1E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023736; ENSMUSP00000023736; ENSMUSG00000022999. [Q9D1E5-1]
ENSMUST00000109127; ENSMUSP00000104755; ENSMUSG00000022999. [Q9D1E5-2]
GeneIDi74775.
KEGGimmu:74775.
UCSCiuc007xoi.1. mouse. [Q9D1E5-1]

Organism-specific databases

CTDi55716.
MGIiMGI:1289247. Lmbr1l.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG246746.
GeneTreeiENSGT00390000007809.
HOGENOMiHOG000252995.
HOVERGENiHBG072983.
InParanoidiQ9D1E5.
OMAiRVYETFT.
OrthoDBiEOG7M0NRC.
PhylomeDBiQ9D1E5.
TreeFamiTF313485.

Miscellaneous databases

NextBioi341610.
PROiQ9D1E5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D1E5.
CleanExiMM_LMBR1L.
GenevestigatoriQ9D1E5.

Family and domain databases

InterProiIPR008075. Lipcalin_1_rcpt.
IPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamiPF04791. LMBR1. 1 hit.
[Graphical view]
PRINTSiPR01692. LIPOCALINIMR.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse uteroglobin receptor."
    Mukherjee A.B., Zhang Z., Chowdhury B.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Dendritic cell, Embryo, Kidney, Pituitary and Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiLMBRL_MOUSE
AccessioniPrimary (citable) accession number: Q9D1E5
Secondary accession number(s): Q3TD82, Q69ZP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.