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Protein

Collagen triple helix repeat-containing protein 1

Gene

Cthrc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a negative regulator of collagen matrix deposition.By similarity

GO - Molecular functioni

  • frizzled binding Source: MGI
  • Wnt-protein binding Source: MGI

GO - Biological processi

  • cell migration Source: MGI
  • cochlea morphogenesis Source: MGI
  • establishment of planar polarity involved in neural tube closure Source: MGI
  • inner ear receptor stereocilium organization Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • ossification involved in bone remodeling Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of osteoblast proliferation Source: MGI
  • positive regulation of protein binding Source: MGI
  • Wnt signaling pathway, planar cell polarity pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen triple helix repeat-containing protein 1
Gene namesi
Name:Cthrc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915838. Cthrc1.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • cytoplasm Source: MGI
  • extracellular space Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 245213Collagen triple helix repeat-containing protein 1PRO_0000021039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D1D6.
PaxDbiQ9D1D6.
PRIDEiQ9D1D6.

PTM databases

PhosphoSiteiQ9D1D6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054196.
CleanExiMM_CTHRC1.
GenevisibleiQ9D1D6. MM.

Interactioni

GO - Molecular functioni

  • frizzled binding Source: MGI
  • Wnt-protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070018.

Structurei

3D structure databases

ProteinModelPortaliQ9D1D6.
SMRiQ9D1D6. Positions 58-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 9234Collagen-likeAdd
BLAST

Sequence similaritiesi

Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IHSA. Eukaryota.
ENOG4111TT8. LUCA.
GeneTreeiENSGT00390000018094.
HOGENOMiHOG000237344.
HOVERGENiHBG051218.
InParanoidiQ9D1D6.
OMAiVDIAIWV.
OrthoDBiEOG091G0HRY.
TreeFamiTF328705.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPQGRAAPP QLLLGLFLVL LLLLQLSAPI SASENPKVKQ KALIRQREVV
60 70 80 90 100
DLYNGMCLQG PAGVPGRDGS PGANGIPGTP GIPGRDGFKG EKGECLRESF
110 120 130 140 150
EESWTPNYKQ CSWSSLNYGI DLGKIAECTF TKMRSNSALR VLFSGSLRLK
160 170 180 190 200
CRNACCQRWY FTFNGAECSG PLPIEAIIYL DQGSPELNST INIHRTSSVE
210 220 230 240
GLCEGIGAGL VDVAIWVGTC SDYPKGDAST GWNSVSRIII EELPK
Length:245
Mass (Da):26,460
Last modified:October 3, 2012 - v2
Checksum:iE4441BF70E4C8436
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411K → Q in BAB22930 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003674 mRNA. Translation: BAB22930.1.
AK151282 mRNA. Translation: BAE30268.1.
AC164883 Genomic DNA. No translation available.
CH466541 Genomic DNA. Translation: EDL08785.1.
CCDSiCCDS27442.1.
RefSeqiNP_081054.1. NM_026778.2.
UniGeneiMm.41556.

Genome annotation databases

EnsembliENSMUST00000067072; ENSMUSP00000070018; ENSMUSG00000054196.
ENSMUST00000202235; ENSMUSP00000144506; ENSMUSG00000106929.
GeneIDi68588.
KEGGimmu:68588.
UCSCiuc007voa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003674 mRNA. Translation: BAB22930.1.
AK151282 mRNA. Translation: BAE30268.1.
AC164883 Genomic DNA. No translation available.
CH466541 Genomic DNA. Translation: EDL08785.1.
CCDSiCCDS27442.1.
RefSeqiNP_081054.1. NM_026778.2.
UniGeneiMm.41556.

3D structure databases

ProteinModelPortaliQ9D1D6.
SMRiQ9D1D6. Positions 58-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070018.

PTM databases

PhosphoSiteiQ9D1D6.

Proteomic databases

MaxQBiQ9D1D6.
PaxDbiQ9D1D6.
PRIDEiQ9D1D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067072; ENSMUSP00000070018; ENSMUSG00000054196.
ENSMUST00000202235; ENSMUSP00000144506; ENSMUSG00000106929.
GeneIDi68588.
KEGGimmu:68588.
UCSCiuc007voa.1. mouse.

Organism-specific databases

CTDi115908.
MGIiMGI:1915838. Cthrc1.

Phylogenomic databases

eggNOGiENOG410IHSA. Eukaryota.
ENOG4111TT8. LUCA.
GeneTreeiENSGT00390000018094.
HOGENOMiHOG000237344.
HOVERGENiHBG051218.
InParanoidiQ9D1D6.
OMAiVDIAIWV.
OrthoDBiEOG091G0HRY.
TreeFamiTF328705.

Miscellaneous databases

PROiQ9D1D6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054196.
CleanExiMM_CTHRC1.
GenevisibleiQ9D1D6. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCTHR1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1D6
Secondary accession number(s): Q3UAP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.