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Protein

Vacuolar protein sorting-associated protein 28 homolog

Gene

Vps28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 28 homolog
Alternative name(s):
Caspase-activated DNase inhibitor that interacts with ASK1
Short name:
CIIA
ESCRT-I complex subunit VPS28
Gene namesi
Name:Vps28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914164. Vps28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209521 – 221Vacuolar protein sorting-associated protein 28 homologAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1C8.
MaxQBiQ9D1C8.
PaxDbiQ9D1C8.
PeptideAtlasiQ9D1C8.
PRIDEiQ9D1C8.

PTM databases

iPTMnetiQ9D1C8.
PhosphoSitePlusiQ9D1C8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059323.
CleanExiMM_VPS28.
ExpressionAtlasiQ9D1C8. baseline and differential.
GenevisibleiQ9D1C8. MM.

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS37B, VPS37C, MVB12A and MVB12B. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts WITH VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25. Interacts with CEP55 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211806. 36 interactors.
IntActiQ9D1C8. 35 interactors.
MINTiMINT-218076.
STRINGi10090.ENSMUSP00000077856.

Structurei

3D structure databases

ProteinModelPortaliQ9D1C8.
SMRiQ9D1C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 120VPS28 N-terminalPROSITE-ProRule annotationAdd BLAST108
Domaini124 – 220VPS28 C-terminalPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the VPS28 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3284. Eukaryota.
ENOG4111IQ4. LUCA.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000203818.
HOVERGENiHBG054248.
InParanoidiQ9D1C8.
KOiK12184.
OMAiKYRLDCP.
PhylomeDBiQ9D1C8.
TreeFamiTF313364.

Family and domain databases

InterProiView protein in InterPro
IPR037202. ESCRT_assembly_dom.
IPR007143. VPS28.
IPR017899. VPS28_C.
IPR037206. VPS28_C_sf.
IPR017898. VPS28_N.
PANTHERiPTHR12937. PTHR12937. 1 hit.
PfamiView protein in Pfam
PF03997. VPS28. 1 hit.
PIRSFiPIRSF017535. VPS28. 1 hit.
SUPFAMiSSF140111. SSF140111. 1 hit.
SSF140427. SSF140427. 1 hit.
PROSITEiView protein in PROSITE
PS51310. VPS28_C. 1 hit.
PS51313. VPS28_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D1C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHGIPATPG VGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ
60 70 80 90 100
ALEKAYIKDC VTPNEYTAAC SRLLVQYKAA FRQVQGSEIS SIDEFCRKFR
110 120 130 140 150
LDCPLAMERI KEDRPITIKD DKGNLNRCIA DVVSLFITVM DKLRLEIRAM
160 170 180 190 200
DEIQPDLREL METMHRMSHL PPDFEGRQTV SQWLQTLSGM SASDELDDSQ
210 220
VRQMLFDLES AYNAFNRFLH A
Length:221
Mass (Da):25,452
Last modified:June 1, 2001 - v1
Checksum:iDC144A4A27857245
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373710 mRNA. Translation: AAN71982.1.
AK003699 mRNA. Translation: BAB22945.1.
BC013535 mRNA. Translation: AAH13535.1.
CCDSiCCDS27579.1.
RefSeqiNP_001292597.1. NM_001305668.1.
NP_080118.1. NM_025842.4.
UniGeneiMm.30028.

Genome annotation databases

EnsembliENSMUST00000078803; ENSMUSP00000077856; ENSMUSG00000059323.
GeneIDi66914.
KEGGimmu:66914.
UCSCiuc007wlc.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiVPS28_MOUSE
AccessioniPrimary (citable) accession number: Q9D1C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families