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Protein

Vacuolar protein sorting-associated protein 28 homolog

Gene

Vps28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 28 homolog
Alternative name(s):
Caspase-activated DNase inhibitor that interacts with ASK1
Short name:
CIIA
ESCRT-I complex subunit VPS28
Gene namesi
Name:Vps28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914164. Vps28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Vacuolar protein sorting-associated protein 28 homologPRO_0000120952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1C8.
MaxQBiQ9D1C8.
PaxDbiQ9D1C8.
PeptideAtlasiQ9D1C8.
PRIDEiQ9D1C8.

PTM databases

iPTMnetiQ9D1C8.
PhosphoSiteiQ9D1C8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062381.
CleanExiMM_VPS28.
ExpressionAtlasiQ9D1C8. baseline and differential.
GenevisibleiQ9D1C8. MM.

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS37B, VPS37C, MVB12A and MVB12B. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Interacts WITH VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25. Interacts with CEP55 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211806. 35 interactions.
IntActiQ9D1C8. 35 interactions.
MINTiMINT-218076.
STRINGi10090.ENSMUSP00000077856.

Structurei

3D structure databases

ProteinModelPortaliQ9D1C8.
SMRiQ9D1C8. Positions 24-117, 123-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 120108VPS28 N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini124 – 22097VPS28 C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the VPS28 family.PROSITE-ProRule annotation
Contains 1 VPS28 C-terminal domain.PROSITE-ProRule annotation
Contains 1 VPS28 N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3284. Eukaryota.
ENOG4111IQ4. LUCA.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000203818.
HOVERGENiHBG054248.
InParanoidiQ9D1C8.
KOiK12184.
OMAiKYRLDCP.
PhylomeDBiQ9D1C8.
TreeFamiTF313364.

Family and domain databases

InterProiIPR007143. VPS28.
IPR017899. VPS28_C.
IPR017898. VPS28_N.
[Graphical view]
PANTHERiPTHR12937. PTHR12937. 1 hit.
PfamiPF03997. VPS28. 1 hit.
[Graphical view]
PIRSFiPIRSF017535. VPS28. 1 hit.
PROSITEiPS51310. VPS28_C. 1 hit.
PS51313. VPS28_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D1C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHGIPATPG VGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ
60 70 80 90 100
ALEKAYIKDC VTPNEYTAAC SRLLVQYKAA FRQVQGSEIS SIDEFCRKFR
110 120 130 140 150
LDCPLAMERI KEDRPITIKD DKGNLNRCIA DVVSLFITVM DKLRLEIRAM
160 170 180 190 200
DEIQPDLREL METMHRMSHL PPDFEGRQTV SQWLQTLSGM SASDELDDSQ
210 220
VRQMLFDLES AYNAFNRFLH A
Length:221
Mass (Da):25,452
Last modified:June 1, 2001 - v1
Checksum:iDC144A4A27857245
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373710 mRNA. Translation: AAN71982.1.
AK003699 mRNA. Translation: BAB22945.1.
BC013535 mRNA. Translation: AAH13535.1.
CCDSiCCDS27579.1.
RefSeqiNP_001292597.1. NM_001305668.1.
NP_080118.1. NM_025842.4.
UniGeneiMm.30028.

Genome annotation databases

EnsembliENSMUST00000078803; ENSMUSP00000077856; ENSMUSG00000059323.
GeneIDi66914.
KEGGimmu:66914.
UCSCiuc007wlc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373710 mRNA. Translation: AAN71982.1.
AK003699 mRNA. Translation: BAB22945.1.
BC013535 mRNA. Translation: AAH13535.1.
CCDSiCCDS27579.1.
RefSeqiNP_001292597.1. NM_001305668.1.
NP_080118.1. NM_025842.4.
UniGeneiMm.30028.

3D structure databases

ProteinModelPortaliQ9D1C8.
SMRiQ9D1C8. Positions 24-117, 123-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211806. 35 interactions.
IntActiQ9D1C8. 35 interactions.
MINTiMINT-218076.
STRINGi10090.ENSMUSP00000077856.

PTM databases

iPTMnetiQ9D1C8.
PhosphoSiteiQ9D1C8.

Proteomic databases

EPDiQ9D1C8.
MaxQBiQ9D1C8.
PaxDbiQ9D1C8.
PeptideAtlasiQ9D1C8.
PRIDEiQ9D1C8.

Protocols and materials databases

DNASUi66914.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078803; ENSMUSP00000077856; ENSMUSG00000059323.
GeneIDi66914.
KEGGimmu:66914.
UCSCiuc007wlc.2. mouse.

Organism-specific databases

CTDi51160.
MGIiMGI:1914164. Vps28.

Phylogenomic databases

eggNOGiKOG3284. Eukaryota.
ENOG4111IQ4. LUCA.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000203818.
HOVERGENiHBG054248.
InParanoidiQ9D1C8.
KOiK12184.
OMAiKYRLDCP.
PhylomeDBiQ9D1C8.
TreeFamiTF313364.

Miscellaneous databases

ChiTaRSiVps28. mouse.
PROiQ9D1C8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062381.
CleanExiMM_VPS28.
ExpressionAtlasiQ9D1C8. baseline and differential.
GenevisibleiQ9D1C8. MM.

Family and domain databases

InterProiIPR007143. VPS28.
IPR017899. VPS28_C.
IPR017898. VPS28_N.
[Graphical view]
PANTHERiPTHR12937. PTHR12937. 1 hit.
PfamiPF03997. VPS28. 1 hit.
[Graphical view]
PIRSFiPIRSF017535. VPS28. 1 hit.
PROSITEiPS51310. VPS28_C. 1 hit.
PS51313. VPS28_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPS28_MOUSE
AccessioniPrimary (citable) accession number: Q9D1C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.