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Q9D1C2

- CBY1_MOUSE

UniProt

Q9D1C2 - CBY1_MOUSE

Protein

Protein chibby homolog 1

Gene

Cby1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins By similarity. Promotes adipocyte and cardiomyocyte differentiation.By similarity2 Publications

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: UniProtKB
    2. cilium assembly Source: MGI
    3. fat cell differentiation Source: UniProtKB
    4. negative regulation of canonical Wnt signaling pathway Source: MGI
    5. negative regulation of transcription, DNA-templated Source: Ensembl
    6. protein localization Source: Ensembl

    Keywords - Biological processi

    Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_219771. deactivation of the beta-catenin transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein chibby homolog 1
    Alternative name(s):
    Cytosolic leucine-rich protein
    PIGEA-14
    PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
    Gene namesi
    Name:Cby1
    Synonyms:Cby, Pgea1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1920989. Cby1.

    Subcellular locationi

    Nucleus speckle By similarity. Golgi apparatustrans-Golgi network By similarity
    Note: Nuclear, in a punctate manner. Also found in the trans-Golgi By similarity.By similarity

    GO - Cellular componenti

    1. ciliary basal body Source: MGI
    2. nuclear speck Source: UniProtKB-SubCell
    3. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Protein chibby homolog 1PRO_0000058355Add
    BLAST

    Proteomic databases

    PaxDbiQ9D1C2.
    PRIDEiQ9D1C2.

    PTM databases

    PhosphoSiteiQ9D1C2.

    Expressioni

    Tissue specificityi

    Found in heart, brain, lung, liver, muscle, kidney and testis. Levels are approximately 3-fold higher in embryonic and adult heart than in lung or liver.1 Publication

    Developmental stagei

    Ubiquitously expressed in early stages of embryonic stem cell differentiation but decreases at later stages when high expression is restricted to cardiomyocytes.1 Publication

    Gene expression databases

    BgeeiQ9D1C2.
    CleanExiMM_CBY1.
    GenevestigatoriQ9D1C2.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin By similarity.By similarity

    Protein-protein interaction databases

    BioGridi216224. 2 interactions.
    STRINGi10090.ENSMUSP00000023064.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D1C2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 11253Minimal region for the interaction with PKD2By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili68 – 11043Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chibby family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39404.
    GeneTreeiENSGT00510000047043.
    HOGENOMiHOG000006694.
    HOVERGENiHBG050816.
    InParanoidiQ9D1C2.
    OMAiNAFRINK.
    OrthoDBiEOG70KGRH.
    PhylomeDBiQ9D1C2.
    TreeFamiTF324419.

    Family and domain databases

    InterProiIPR028118. Chibby_fam.
    [Graphical view]
    PfamiPF14645. Chibby. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D1C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ    50
    SLKFENGQWV ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD 100
    MLSETTAESH LKDKELDELK VTNRRRK 127
    Length:127
    Mass (Da):14,535
    Last modified:June 1, 2001 - v1
    Checksum:i7CE38A48D045CCC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331040 mRNA. Translation: AAL56061.1.
    AK003719 mRNA. Translation: BAB22956.1.
    BC005733 mRNA. Translation: AAH05733.1.
    CCDSiCCDS27645.1.
    RefSeqiNP_082910.1. NM_028634.3.
    UniGeneiMm.294441.

    Genome annotation databases

    EnsembliENSMUST00000023064; ENSMUSP00000023064; ENSMUSG00000022428.
    GeneIDi73739.
    KEGGimmu:73739.
    UCSCiuc007wuc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331040 mRNA. Translation: AAL56061.1 .
    AK003719 mRNA. Translation: BAB22956.1 .
    BC005733 mRNA. Translation: AAH05733.1 .
    CCDSi CCDS27645.1.
    RefSeqi NP_082910.1. NM_028634.3.
    UniGenei Mm.294441.

    3D structure databases

    ProteinModelPortali Q9D1C2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 216224. 2 interactions.
    STRINGi 10090.ENSMUSP00000023064.

    PTM databases

    PhosphoSitei Q9D1C2.

    Proteomic databases

    PaxDbi Q9D1C2.
    PRIDEi Q9D1C2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023064 ; ENSMUSP00000023064 ; ENSMUSG00000022428 .
    GeneIDi 73739.
    KEGGi mmu:73739.
    UCSCi uc007wuc.1. mouse.

    Organism-specific databases

    CTDi 25776.
    MGIi MGI:1920989. Cby1.

    Phylogenomic databases

    eggNOGi NOG39404.
    GeneTreei ENSGT00510000047043.
    HOGENOMi HOG000006694.
    HOVERGENi HBG050816.
    InParanoidi Q9D1C2.
    OMAi NAFRINK.
    OrthoDBi EOG70KGRH.
    PhylomeDBi Q9D1C2.
    TreeFami TF324419.

    Enzyme and pathway databases

    Reactomei REACT_219771. deactivation of the beta-catenin transactivating complex.

    Miscellaneous databases

    NextBioi 338953.
    PROi Q9D1C2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D1C2.
    CleanExi MM_CBY1.
    Genevestigatori Q9D1C2.

    Family and domain databases

    InterProi IPR028118. Chibby_fam.
    [Graphical view ]
    Pfami PF14645. Chibby. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel cytosolic leucine-rich protein."
      Huang C.-H.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells."
      Singh A.M., Li F.-Q., Hamazaki T., Kasahara H., Takemaru K., Terada N.
      Circulation 115:617-626(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    5. "Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling."
      Li F.-Q., Singh A.M., Mofunanya A., Love D., Terada N., Moon R.T., Takemaru K.
      Mol. Cell. Biol. 27:4347-4354(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCBY1_MOUSE
    AccessioniPrimary (citable) accession number: Q9D1C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3