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Protein

Cystatin

Gene

Cst6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: MGI
  • negative regulation of cysteine-type endopeptidase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitorUniRule annotation

Protein family/group databases

MEROPSiI25.006.

Names & Taxonomyi

Protein namesi
Recommended name:
CystatinUniRule annotation
Gene namesi
Name:Cst6Imported
ORF Names:mCG_11738Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1920970. Cst6.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28UniRule annotationAdd BLAST28
ChainiPRO_500845248229 – 149CystatinUniRule annotationAdd BLAST121

Expressioni

Gene expression databases

BgeeiENSMUSG00000024846.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025764.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 147CystatinInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the cystatin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J4P1. Eukaryota.
ENOG410Y20I. LUCA.
GeneTreeiENSGT00860000133825.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
KOiK13902.
OMAiSLYYFRD.
OrthoDBiEOG091G0TP1.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D1B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPHFPLAM GLGLLAFCLL TLSPDARAEL RSRRTGERQN LSPTDPRVQK
60 70 80 90 100
AAQAAVASYN MGSDSLYYFR DTKVIDAKYQ LVAGIKYYLT LDIESTECRK
110 120 130 140
TRVSGEHMDL TTCPLAAGGQ QEKLRCNFEL LEVPWKNTTQ LLKHDCVQV
Length:149
Mass (Da):16,796
Last modified:June 1, 2001 - v1
Checksum:iE713EB920E0EFCC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122861 Genomic DNA. No translation available.
BC061036 mRNA. Translation: AAH61036.1.
AY093591 Genomic DNA. Translation: AAM11475.1.
AK003744 mRNA. Translation: BAB22976.1.
AK078116 mRNA. Translation: BAC37132.1.
CH466612 Genomic DNA. Translation: EDL33113.1.
RefSeqiNP_082899.1. NM_028623.5.
UniGeneiMm.36816.

Genome annotation databases

EnsembliENSMUST00000025764; ENSMUSP00000025764; ENSMUSG00000024846.
GeneIDi73720.
KEGGimmu:73720.
UCSCiuc008gcq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122861 Genomic DNA. No translation available.
BC061036 mRNA. Translation: AAH61036.1.
AY093591 Genomic DNA. Translation: AAM11475.1.
AK003744 mRNA. Translation: BAB22976.1.
AK078116 mRNA. Translation: BAC37132.1.
CH466612 Genomic DNA. Translation: EDL33113.1.
RefSeqiNP_082899.1. NM_028623.5.
UniGeneiMm.36816.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025764.

Protein family/group databases

MEROPSiI25.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025764; ENSMUSP00000025764; ENSMUSG00000024846.
GeneIDi73720.
KEGGimmu:73720.
UCSCiuc008gcq.1. mouse.

Organism-specific databases

CTDi1474.
MGIiMGI:1920970. Cst6.

Phylogenomic databases

eggNOGiENOG410J4P1. Eukaryota.
ENOG410Y20I. LUCA.
GeneTreeiENSGT00860000133825.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
KOiK13902.
OMAiSLYYFRD.
OrthoDBiEOG091G0TP1.

Miscellaneous databases

ChiTaRSiCst6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024846.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9D1B1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1B1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.