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Protein

Cystatin

Gene

Cst6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: MGI
  • negative regulation of cysteine-type endopeptidase activity Source: GO_Central

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitorUniRule annotation

Protein family/group databases

MEROPSiI25.006

Names & Taxonomyi

Protein namesi
Recommended name:
CystatinUniRule annotation
Gene namesi
Name:Cst6Imported
ORF Names:mCG_11738Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1920970 Cst6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28UniRule annotationAdd BLAST28
ChainiPRO_501420604429 – 149CystatinUniRule annotationAdd BLAST121

Expressioni

Gene expression databases

BgeeiENSMUSG00000024846

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025764

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 147CystatinInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the cystatin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J4P1 Eukaryota
ENOG410Y20I LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000231754
HOVERGENiHBG009556
KOiK13902
OMAiSLYYFRD
OrthoDBiEOG091G0TP1

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D1B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPHFPLAM GLGLLAFCLL TLSPDARAEL RSRRTGERQN LSPTDPRVQK
60 70 80 90 100
AAQAAVASYN MGSDSLYYFR DTKVIDAKYQ LVAGIKYYLT LDIESTECRK
110 120 130 140
TRVSGEHMDL TTCPLAAGGQ QEKLRCNFEL LEVPWKNTTQ LLKHDCVQV
Length:149
Mass (Da):16,796
Last modified:June 1, 2001 - v1
Checksum:iE713EB920E0EFCC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122861 Genomic DNA No translation available.
BC061036 mRNA Translation: AAH61036.1
AY093591 Genomic DNA Translation: AAM11475.1
AK003744 mRNA Translation: BAB22976.1
AK078116 mRNA Translation: BAC37132.1
CH466612 Genomic DNA Translation: EDL33113.1
RefSeqiNP_082899.1, NM_028623.5
UniGeneiMm.36816

Genome annotation databases

EnsembliENSMUST00000025764; ENSMUSP00000025764; ENSMUSG00000024846
GeneIDi73720
KEGGimmu:73720
UCSCiuc008gcq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ9D1B1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1B1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health