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Protein

Ankyrin repeat and SOCS box protein 5

Gene

Asb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664. Neddylation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 5
Short name:
ASB-5
Gene namesi
Name:Asb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1923544. Asb5.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669311 – 329Ankyrin repeat and SOCS box protein 5Add BLAST329

Proteomic databases

PaxDbiQ9D1A4.
PRIDEiQ9D1A4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031519.
CleanExiMM_ASB5.
ExpressionAtlasiQ9D1A4. baseline and differential.
GenevisibleiQ9D1A4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033918.

Structurei

3D structure databases

ProteinModelPortaliQ9D1A4.
SMRiQ9D1A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati69 – 98ANK 1Add BLAST30
Repeati102 – 131ANK 2Add BLAST30
Repeati135 – 164ANK 3Add BLAST30
Repeati167 – 196ANK 4Add BLAST30
Repeati200 – 229ANK 5Add BLAST30
Repeati232 – 261ANK 6Add BLAST30
Domaini278 – 329SOCS boxPROSITE-ProRule annotationAdd BLAST52

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ9D1A4.
KOiK10327.
OMAiLEILISW.
OrthoDBiEOG091G0DYR.
PhylomeDBiQ9D1A4.
TreeFamiTF331945.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 4 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D1A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLEESRPF AQQLSNVYFT ILSLFCFKLF VKISLAILSH FYIVKGNRKE
60 70 80 90 100
AARIAAEFYG VSQGQGSWAD RSPLHEAASQ GRLLALRTLL SQGYNVNAVT
110 120 130 140 150
IDHVTPLHEA CLGDHVACAR TLLEAGANAN AITIDGVTPL FNACSQGSAS
160 170 180 190 200
CAELLLEYGA KAQLESCFPS PTHEAASKGH HECLDILIAW GIDVDQDIPH
210 220 230 240 250
LGTPLYVACM SQQFHCIWKL LYAGADVHKG KYWDTPLHAA AQQPSTEIVN
260 270 280 290 300
LLLEFGADIN AKNTDLLRPV DLATSNSAVE RILLQHEATP SSLCQLCRLC
310 320
IRNYIGRQRF HLIPQLQLPT LLQNFLQYR
Length:329
Mass (Da):36,282
Last modified:June 1, 2001 - v1
Checksum:i7556C8A984A12BF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003770 mRNA. Translation: BAB22987.1.
AF398966 mRNA. Translation: AAK97488.1.
CCDSiCCDS22307.1.
RefSeqiNP_083845.1. NM_029569.3.
UniGeneiMm.33171.

Genome annotation databases

EnsembliENSMUST00000033918; ENSMUSP00000033918; ENSMUSG00000031519.
GeneIDi76294.
KEGGimmu:76294.
UCSCiuc009lse.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiASB5_MOUSE
AccessioniPrimary (citable) accession number: Q9D1A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families