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Protein

Pre-mRNA-splicing factor SYF2

Gene

Syf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

  • embryonic organ development Source: MGI
  • gastrulation Source: MGI
  • in utero embryonic development Source: MGI
  • mitotic G2 DNA damage checkpoint Source: MGI
  • mRNA splicing, via spliceosome Source: GO_Central
  • positive regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SYF2
Alternative name(s):
CCNDBP1-interactor
mp29
p29
Gene namesi
Name:Syf2
Synonyms:Cbpin, Gcipip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915842. Syf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 242241Pre-mRNA-splicing factor SYF2PRO_0000250377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D198.
MaxQBiQ9D198.
PaxDbiQ9D198.
PeptideAtlasiQ9D198.
PRIDEiQ9D198.

PTM databases

PhosphoSiteiQ9D198.

Expressioni

Tissue specificityi

Abundantly expressed in the heart, liver and kidney. Expressed at lower level other tissues.1 Publication

Gene expression databases

BgeeiQ9D198.
CleanExiMM_SYF2.
GenevisibleiQ9D198. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with CCNDBP1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9D198. 1 interaction.
STRINGi10090.ENSMUSP00000030622.

Structurei

3D structure databases

ProteinModelPortaliQ9D198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili65 – 9127Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SYF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2609. Eukaryota.
ENOG410XY86. LUCA.
GeneTreeiENSGT00390000017845.
HOGENOMiHOG000190170.
HOVERGENiHBG080129.
InParanoidiQ9D198.
KOiK12868.
OMAiEKWERKK.
OrthoDBiEOG7BCNCP.
PhylomeDBiQ9D198.
TreeFamiTF313041.

Family and domain databases

InterProiIPR013260. mRNA_splic_SYF2.
[Graphical view]
PANTHERiPTHR13264. PTHR13264. 1 hit.
PfamiPF08231. SYF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVTEVVVP ADGAEARPLA AEELAAQKRE QRLRKFRELH LKRNEARKLN
60 70 80 90 100
HQEVVEEDKR LKLPANWEAK KARLEWELQE EEKKKECAAR GEDYEKVKLL
110 120 130 140 150
EISAEDAERW ERRKKKKNPD LGFSDYAAAQ LRQYHRLTKQ IKPDMESYER
160 170 180 190 200
QREKHGEDFF PTSNSLLHGT HVPSSEEIDR MVLDLEKQIE KRDKYSRRRP
210 220 230 240
YNDDADIDYI NERNAKFNKK AERFYGKYTA EIKQNLERGT AV
Length:242
Mass (Da):28,712
Last modified:June 1, 2001 - v1
Checksum:iFFCC25142541B847
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155574 Genomic DNA. Translation: AAO06147.1.
AY033432 mRNA. Translation: AAK54459.1.
AK003787 mRNA. Translation: BAB22995.1.
AK152794 mRNA. Translation: BAE31500.1.
BC051484 mRNA. Translation: AAH51484.1.
CCDSiCCDS18781.1.
RefSeqiNP_081056.1. NM_026780.3.
UniGeneiMm.29989.

Genome annotation databases

EnsembliENSMUST00000030622; ENSMUSP00000030622; ENSMUSG00000028821.
GeneIDi68592.
KEGGimmu:68592.
UCSCiuc008vga.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155574 Genomic DNA. Translation: AAO06147.1.
AY033432 mRNA. Translation: AAK54459.1.
AK003787 mRNA. Translation: BAB22995.1.
AK152794 mRNA. Translation: BAE31500.1.
BC051484 mRNA. Translation: AAH51484.1.
CCDSiCCDS18781.1.
RefSeqiNP_081056.1. NM_026780.3.
UniGeneiMm.29989.

3D structure databases

ProteinModelPortaliQ9D198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D198. 1 interaction.
STRINGi10090.ENSMUSP00000030622.

PTM databases

PhosphoSiteiQ9D198.

Proteomic databases

EPDiQ9D198.
MaxQBiQ9D198.
PaxDbiQ9D198.
PeptideAtlasiQ9D198.
PRIDEiQ9D198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030622; ENSMUSP00000030622; ENSMUSG00000028821.
GeneIDi68592.
KEGGimmu:68592.
UCSCiuc008vga.1. mouse.

Organism-specific databases

CTDi25949.
MGIiMGI:1915842. Syf2.

Phylogenomic databases

eggNOGiKOG2609. Eukaryota.
ENOG410XY86. LUCA.
GeneTreeiENSGT00390000017845.
HOGENOMiHOG000190170.
HOVERGENiHBG080129.
InParanoidiQ9D198.
KOiK12868.
OMAiEKWERKK.
OrthoDBiEOG7BCNCP.
PhylomeDBiQ9D198.
TreeFamiTF313041.

Miscellaneous databases

ChiTaRSiSyf2. mouse.
PROiQ9D198.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D198.
CleanExiMM_SYF2.
GenevisibleiQ9D198. MM.

Family and domain databases

InterProiIPR013260. mRNA_splic_SYF2.
[Graphical view]
PANTHERiPTHR13264. PTHR13264. 1 hit.
PfamiPF08231. SYF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: 129/SvJ.
  2. "Identification of GCIP-interacting protein p29 (p29) in mouse."
    Xia C., Liu M.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiSYF2_MOUSE
AccessioniPrimary (citable) accession number: Q9D198
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.