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Protein

Mitochondrial import receptor subunit TOM7 homolog

Gene

Tomm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM7 homolog
Alternative name(s):
Translocase of outer membrane 7 kDa subunit homolog
Gene namesi
Name:Tomm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913419. Tomm7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicBy similarityAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 55Mitochondrial intermembraneBy similarityAdd BLAST15

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467601 – 55Mitochondrial import receptor subunit TOM7 homologAdd BLAST55

Proteomic databases

MaxQBiQ9D173.
PaxDbiQ9D173.
PeptideAtlasiQ9D173.
PRIDEiQ9D173.
TopDownProteomicsiQ9D173.

PTM databases

iPTMnetiQ9D173.
PhosphoSitePlusiQ9D173.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028998.
GenevisibleiQ9D173. MM.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030851.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4449. Eukaryota.
ENOG41123F4. LUCA.
GeneTreeiENSGT00390000014833.
HOGENOMiHOG000039474.
HOVERGENiHBG065915.
InParanoidiQ9D173.
KOiK17771.
OMAiVLYLGFR.
OrthoDBiEOG091G1AL9.
PhylomeDBiQ9D173.
TreeFamiTF106199.

Family and domain databases

InterProiView protein in InterPro
IPR012621. Tom7.
PfamiView protein in Pfam
PF08038. Tom7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLSKEAKQ RLQQLFKGGQ FAIRWGFIPL VIYLGFTRGA DPGMPEPSVL

SLLWG
Length:55
Mass (Da):6,177
Last modified:June 1, 2001 - v1
Checksum:i690E93658C3BEF15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003864 mRNA. Translation: BAB23046.1.
BC055352 mRNA. Translation: AAH55352.1.
CCDSiCCDS39026.1.
RefSeqiNP_079670.1. NM_025394.3.
UniGeneiMm.291868.

Genome annotation databases

EnsembliENSMUST00000030851; ENSMUSP00000030851; ENSMUSG00000028998.
GeneIDi66169.
KEGGimmu:66169.
UCSCiuc008wqs.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTOM7_MOUSE
AccessioniPrimary (citable) accession number: Q9D173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families