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Protein

ES1 protein homolog, mitochondrial

Gene

D10Jhu81e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ES1 protein homolog, mitochondrial
Gene namesi
Name:D10Jhu81e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1351861. D10Jhu81e.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionBy similarityAdd
BLAST
Chaini40 – 266227ES1 protein homolog, mitochondrialPRO_0000008545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491N6-acetyllysineCombined sources
Modified residuei155 – 1551N6-acetyllysineCombined sources
Modified residuei162 – 1621N6-acetyllysineCombined sources
Modified residuei201 – 2011N6-acetyllysine; alternateCombined sources
Modified residuei201 – 2011N6-succinyllysine; alternateCombined sources
Modified residuei217 – 2171N6-acetyllysineCombined sources
Modified residuei221 – 2211N6-acetyllysine; alternateCombined sources
Modified residuei221 – 2211N6-succinyllysine; alternateCombined sources
Modified residuei231 – 2311N6-acetyllysine; alternateCombined sources
Modified residuei231 – 2311N6-succinyllysine; alternateCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D172.
MaxQBiQ9D172.
PaxDbiQ9D172.
PeptideAtlasiQ9D172.
PRIDEiQ9D172.

2D gel databases

REPRODUCTION-2DPAGEQ9D172.

PTM databases

iPTMnetiQ9D172.
PhosphoSiteiQ9D172.
SwissPalmiQ9D172.

Expressioni

Gene expression databases

BgeeiQ9D172.
GenevisibleiQ9D172. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D172. 3 interactions.
MINTiMINT-1841972.
STRINGi10090.ENSMUSP00000001242.

Structurei

3D structure databases

ProteinModelPortaliQ9D172.
SMRiQ9D172. Positions 42-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ES1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IH62. Eukaryota.
COG3155. LUCA.
GeneTreeiENSGT00390000003706.
HOGENOMiHOG000269874.
HOVERGENiHBG001844.
InParanoidiQ9D172.
OMAiAQVQCFA.
OrthoDBiEOG77M8PJ.
PhylomeDBiQ9D172.
TreeFamiTF329408.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVRVLVAP RLASALLPLS RYHRAPSQRA ALHSSAPRPG ARVALVLSGC
60 70 80 90 100
GVYDGTEIHE ASAILVHLSR GGAEVQIFAP DVPQMHVIDH TKGEPSERES
110 120 130 140 150
RNVLAESARI ARGKITSLAQ LNAANHDAAI FPGGFGAAKN LSTFAVDGKD
160 170 180 190 200
CKVNKEVERV LKEFHGAKKP IGLCCIAPVL AAKVIKGVEV TVGHEQEEGG
210 220 230 240 250
KWPYAGTAEA IKALGAKHCV KGVTEAHVDQ KNKVVTTPAF MCETALHHIH
260
DGIGAMVKNV LELTGK
Length:266
Mass (Da):28,090
Last modified:June 1, 2001 - v1
Checksum:i9F311AD7288F4C2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003866 mRNA. Translation: BAB23047.1.
BC013475 mRNA. Translation: AAH13475.1.
CCDSiCCDS35957.1.
RefSeqiNP_613067.1. NM_138601.2.
XP_006544850.1. XM_006544787.2.
UniGeneiMm.268691.

Genome annotation databases

EnsembliENSMUST00000001242; ENSMUSP00000001242; ENSMUSG00000053329.
GeneIDi102641949.
28295.
KEGGimmu:102641949.
mmu:28295.
UCSCiuc007fxj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003866 mRNA. Translation: BAB23047.1.
BC013475 mRNA. Translation: AAH13475.1.
CCDSiCCDS35957.1.
RefSeqiNP_613067.1. NM_138601.2.
XP_006544850.1. XM_006544787.2.
UniGeneiMm.268691.

3D structure databases

ProteinModelPortaliQ9D172.
SMRiQ9D172. Positions 42-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D172. 3 interactions.
MINTiMINT-1841972.
STRINGi10090.ENSMUSP00000001242.

PTM databases

iPTMnetiQ9D172.
PhosphoSiteiQ9D172.
SwissPalmiQ9D172.

2D gel databases

REPRODUCTION-2DPAGEQ9D172.

Proteomic databases

EPDiQ9D172.
MaxQBiQ9D172.
PaxDbiQ9D172.
PeptideAtlasiQ9D172.
PRIDEiQ9D172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001242; ENSMUSP00000001242; ENSMUSG00000053329.
GeneIDi102641949.
28295.
KEGGimmu:102641949.
mmu:28295.
UCSCiuc007fxj.1. mouse.

Organism-specific databases

MGIiMGI:1351861. D10Jhu81e.

Phylogenomic databases

eggNOGiENOG410IH62. Eukaryota.
COG3155. LUCA.
GeneTreeiENSGT00390000003706.
HOGENOMiHOG000269874.
HOVERGENiHBG001844.
InParanoidiQ9D172.
OMAiAQVQCFA.
OrthoDBiEOG77M8PJ.
PhylomeDBiQ9D172.
TreeFamiTF329408.

Miscellaneous databases

PROiQ9D172.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D172.
GenevisibleiQ9D172. MM.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 71-92; 102-109; 115-149; 169-183; 187-212 AND 222-231, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J and OF1.
    Tissue: Brain and Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-201; LYS-221 AND LYS-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-149; LYS-155; LYS-162; LYS-201; LYS-217; LYS-221 AND LYS-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiES1_MOUSE
AccessioniPrimary (citable) accession number: Q9D172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.